DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and PPFIA1

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_006718779.1	Gene:	PPFIA1 / 8500	HGNCID:	9245	Length:	1306	Species:	Homo sapiens

Alignment Length:	1347	Identity:	306/1347 - (22%)
Similarity:	480/1347 - (35%)	Gaps:	453/1347 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LHKLGESKIAKSLDTSVSTGLKEKAASVNNNKPI--RPLLSLDSSVTASTSSGATGSGGGGAPAK 94
            ||::|..:  .||...::|.|.::.|::.....:  ..||..:..:....           |...
Human    68 LHEVGHER--DSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELK-----------AERN 119

  Fly    95 PSPLVLASKRDLTPSNESS----------SSPSSSNGSNQTLTPPMTADNQPLQQQLQHHQHRSP 149
            .:.|:|.....|...:|.|          .||:..:...:.|        :.|:...:||:
Human   120 NTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVL--------KALKSLFEHHK---- 172

  Fly   150 AYPGKP--------------AEAAGG-------VPQQQQQQQQLPNGI-GSSHCNSNSNGISSTC 192
            |...|.              .|..|.       :.:|..|::.|.:|: ..:|...|:...|...
Human   173 ALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKR 237

  Fly   193 NSGTAMIHANNSNLIAAGHLAQAAGPAHNAPSSGSALNAVDKRNANLS----EPDQDL------- 246
            :|..::.|..:        ||:...............:.:.:|.|:||    |.::||
Human   238 SSDGSLSHEED--------LAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDL 294

  Fly   247 --PPNLNVNLSPNPSLALGAPHSPTSAASAALLLLESCDGNRNDESRFHHL---HSAPRPEATMK 306
              ...:|..|..:                    :.|:.....:.|.|...|   :.|.:.||| .
Human   295 IKSEEMNTKLQRD--------------------VREAMAQKEDMEERITTLEKRYLAAQREAT-S 338

  Fly   307 LREENDRLNAELL--------------RLRRLLELS---TDGAVGGVDTAPEMEA---------- 344
            :.:.||:|..|:.              :|:..|||:   ....:...:|.||:||
Human   339 VHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALS 403

  Fly   345 ---VASGEGSAAK----------------------ERIERLESELRSVKNQLLTMRLERKKLRTD 384
               :.|...||||                      ||:.::|::|.. |||.|....:|:|:..:
Human   404 KSDLLSSGSSAAKEAKLLELTSKLRKAEERHGNIEERLRQMEAQLEE-KNQELQRARQREKMNEE 467

  Fly   385 KSDLLG----------------QVKQLCASLQEKEQELRDFIRNYQERVRET-----------ET 422
            .:..|.                .:|:..|:|::|...||: :.:.::::.||           |.
Human   468 HNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLRE-VESAKKQLEETQHDKDQLVLNIEA 531

  Fly   423 TNAKISGDRDRE----------------RFQLLKQARDEAERSLALAQ----QLSA-RD--LQLQ 464
            ..|::...|.|.                ||.:.....|....|..|.:    :|:| ||  .::|
Human   532 LRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQ 596

  Fly   465 RLQEQLQEARRQLTGCLS-----------------DQESLHSFAPLTPPSAASG------MLSQM 506
            .|.||..| |.|....|:                 |:::|.|...|..||..:.      ||.:.
Human   597 TLNEQDWE-RAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQ 660

  Fly   507 AAA-----------------------SGMGGGLAGMRGTTEDSGRGNSLSAF----SGSLSG--- 541
            ..|                       |.:|.      |:.::.||..|:|:.    :.||:.
Human   661 LDAINKEIRLIQEEKENTEQRAEEIESRVGS------GSLDNLGRFRSMSSIPPYPASSLASSSP 719

  Fly   542 -GSGATA---------------GDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDPD 590
             |||.:.               |.....|.||.|..:|                  ||..:|...
Human   720 PGSGRSTPRRIPHSPAREVDRLGVMTLPSPDSFLIQTS------------------GPHQSVVYS 766

  Fly   591 SISLVSSQNMY----QFGTPK-------------------------ERSPTLSPL--------NS 618
            |.|..||...|    |...|.                         |.||..||.        ..
Human   767 STSPPSSTPCYSDSSQHAQPSDLRKHRRKLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKG 831

  Fly   619 AAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGSISRVFAR------SRN 677
            |.::.|.|.:....:..|..:|.:|...::.|....|.....:.|...||.|:|.:      .:.
Human   832 ALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQT 896

  Fly   678 KNKALSADGVTEYADYSWNPLTEE---GYAEKLR-------LLREASQ--LPIDRWRATQVLAWL 730
            ..:||...||:|..:.|.:.|...   |.|||.|       ||.||.:  ||..:|....|:.||
Human   897 GKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWL 961

  Fly   731 EVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEE------------ 782
            |:.:|||. |.|.|..|||||.::..|:|.|::..:|:::|:||.||||||:|
Human   962 ELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPT 1026

  Fly   783 ---------QRRPEMVRYPLITQ----------------LGHTWVATEWLPDIGLPQYAEPFVQS 822
                     ....||.......|                :.|.|:..||||.:|||||...|::.
Human  1027 SRTTTGNVWLTHEEMETLAATPQTEDEEGSWAQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMEC 1091

  Fly   823 LVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWT 887
            ||||||||.|:||:|...|.:...||:.|...||..||.:.|||:.|..:|.:|::...|.:||:
Human  1092 LVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWS 1156

  Fly   888 NQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDAL 952
            |.|.|||:.||.|.|||:||.:|||||.|:.|:.:|....:|..|.||......|..|..||:.|
Human  1157 NDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNL 1221

  Fly   953 ILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRR-----SSGNLRISAWK------------- 999
            ::     :|                       ||||     .....|..:|:
Human  1222 LV-----MG-----------------------TDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAA 1258

  Fly  1000 GSQSSLSKAFRFNSKPHRTGDRSSFGNSTSPTPSYSSSEGGGGIYAT 1046
            ||..:|...||..|            :.:||:......:..|.:..|
Human  1259 GSAETLPANFRVTS------------SMSSPSMQPKKMQMDGNVSGT 1293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	32/173 (18%)
		SAM_kazrin_repeat1	718..787	CDD:188963	30/90 (33%)
		SAM	719..781	CDD:197735	28/62 (45%)
		SAM_kazrin_repeat2	796..860	CDD:188966	31/79 (39%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	32/70 (46%)
		SAM	885..>934	CDD:197735	25/48 (52%)
PPFIA1	XP_006718779.1	MscS_porin	321..542	CDD:289559	46/223 (21%)
		BAR	<324..>470	CDD:299863	33/147 (22%)
		Stathmin	<416..524	CDD:279209	20/109 (18%)
		SAM_liprin-alpha1,2,3,4_repeat1	949..1019	CDD:188961	30/69 (43%)
		SAM	949..1015	CDD:197735	29/65 (45%)
		SAM_liprin-alpha1,2,3,4_repeat2	1066..1131	CDD:188964	32/64 (50%)
		SAM	1074..1129	CDD:197735	28/54 (52%)
		SAM_liprin-alpha1,2,3,4_repeat3	1151..1222	CDD:188967	32/70 (46%)
		SAM	1152..1222	CDD:197735	31/69 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810