DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and PPFIA2

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_016875568.1	Gene:	PPFIA2 / 8499	HGNCID:	9246	Length:	1260	Species:	Homo sapiens

Alignment Length:	1148	Identity:	286/1148 - (24%)
Similarity:	429/1148 - (37%)	Gaps:	343/1148 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 LTPPMTADNQ---PLQQQLQHHQHRSPAYPG--KPAEAAGGVPQQQQQQQQLPNGIGSSHCNSNS 185
            |...:.|.||   .|::|..|.|.:..:..|  :.....|..|.|:..:::|.||
Human   205 LEEELAAANQEIVALREQNVHIQRKMASSEGSTESEHLEGMEPGQKVHEKRLSNG---------- 259

  Fly   186 NGISSTCNSG-----TAMIHANNSNL------IAA-----GHLAQAAGPAHNAPSSGSALNAV-- 232
             .|.||..:.     ..::...|..:      :||     |.:.|.|..|.........:|..
Human   260 -SIDSTDETSQIVELQELLEKQNYEMAQMKERLAALSSRVGEVEQEAETARKDLIKTEEMNTKYQ 323

  Fly   233 -DKRNANLSEPDQDLPPNLNVNLSPNPSLALGAPHSPTSAASAALLLLESCDGNRNDESRFHHLH 296
             |.|.|...:.|      :...::......|.|....||.            .:.||:..    :
Human   324 RDIREAMAQKED------MEERITTLEKRYLSAQRESTSI------------HDMNDKLE----N 366

  Fly   297 SAPRPEATMKLREENDRLNAELLRLRRLLELSTDGAVGGVDTAPEMEAVASGEGSA--------- 352
            .....||.::..||.:|...|.|   .|.|......:...:|.||:||..:...:|
Human   367 ELANKEAILRQMEEKNRQLQERL---ELAEQKLQQTMRKAETLPEVEAELAQRIAALTKAEERHG 428

  Fly   353 -AKERIERLESELRSVKNQLLTMRLERKKLRTDKSDLLG----------------QVKQLCASLQ 400
             .:||:..||.:|.. |||.|....:|:|:..:.:..|.                .:|:..|:|:
Human   429 NIEERMRHLEGQLEE-KNQELQRARQREKMNEEHNKRLSDTVDRLLTESNERLQLHLKERMAALE 492

  Fly   401 EKE---QELRDFIRNYQERVRETETTNAKISGDRDRERFQLLKQ----------ARDEAERSLAL 452
            ||.   ||...|.:|.:|.:.:.|....:|  ::.|.....||.          .|...:.|..|
Human   493 EKNVLIQESETFRKNLEESLHDKERLAEEI--EKLRSELDQLKMRTGSLIEPTIPRTHLDTSAEL 555

  Fly   453 AQQL-SARDLQLQ-RLQEQLQEARR-----------------------QLTGCLS---------- 482
            ...: |..|.|.. |..:.::..||                       |..|.||
Human   556 RYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEPKVKSLGDHEWNRTQQIGVLSSHPFESDTEM 620

  Fly   483 ------DQESLHSFAPLTPPSAASG------ML-----------------------------SQM 506
                  |:|::.|...|..||..|.      ||                             :::
Human   621 SDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQEQLDAINKEIRLIQEEKESTELRAEEIENRV 685

  Fly   507 AAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGGSGATAGDRNSCSNDSGLRNSSDRESTGGE 571
            |:.|..|..||.:.       .|.|::|   |::..|.|::...:..|.......|..||
Human   686 ASVSLEGLNLARVH-------PGTSITA---SVTASSLASSSPPSGHSTPKLTPRSPARE----- 735

  Fly   572 LNFSDGTCDNGPCITVDPD------SISLVSSQNMYQFGTPK-ERSPTLSP--------LNSAAY 621
                   .|....:|:..|      .|::|.........|.| |.||..:|        |.|:.:
Human   736 -------MDRMGVMTLPSDLRKHRRKIAVVEEDGREDKATIKCETSPPPTPRALRMTHTLPSSYH 793

  Fly   622 SRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGSISRVFARSRNKNKA----L 682
            :.:...|...::||..|.|:     ||:|:.. |.....:.|...||.|:|.:   |.||    |
Human   794 NDARSSLSVSLEPESLGLGS-----ANSSQDS-LHKAPKKKGIKSSIGRLFGK---KEKARLGQL 849

  Fly   683 SADGVTEYADYSWNPLTEEG-YAEKLR----------LLREASQ--LPIDRWRATQVLAWLEVAL 734
            .....||.|......|.:.| .|||.|          ||.||.:  ||..:|....|:||||:.|
Human   850 RGFMETEAAAQESLGLGKLGTQAEKDRRLKKNTSGHELLEEARRKGLPFAQWDGPTVVAWLELWL 914

  Fly   735 GMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEE------------QRRP 786
            |||. |.|.|..|||||.::..|:|.|::..:|:::|:||.||||||:|            .|.|
Human   915 GMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPPTSRTP 979

  Fly   787 ---------EM-----------------VRYPLITQ------LGHTWVATEWLPDIGLPQYAEPF 819
                     ||                 .:.|:..|      :.|.|:..||||.:|||||...|
Human   980 SGNVWVTHEEMENLAAPAKTKESEEGSWAQCPVFLQTLAYGDMNHEWIGNEWLPSLGLPQYRSYF 1044

  Fly   820 VQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPI 884
            ::.||||||||.|:||:|...|.:...||:.|:.:||..|:.:.|||:.|..||..|:....|.:
Human  1045 MECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNYDRKELERRREASQHEIKDVL 1109

  Fly   885 VWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEF 949
            ||:|.|.|||:::|.|.|||:|:.:|||||.|:.|:.:|...::|..|.||......|:.|..|:
Human  1110 VWSNDRVIRWIQAIGLREYANNILESGVHGSLIALDENFDYSSLALLLQIPTQNTQARQILEREY 1174

  Fly   950 DALILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRR----SSGNLR---------------- 994
            :.|:     .||                       |:||    ...|.|
Human  1175 NNLL-----ALG-----------------------TERRLDESDDKNFRRGSTWRRQFPPREVHG 1211

  Fly   995 ISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNSTSPTPSYSSS 1037
            ||...||..:|...||..         ::.|.|...|...:||
Human  1212 ISMMPGSSETLPAGFRLT---------TTSGQSRKMTTDVASS 1245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	29/124 (23%)
		SAM_kazrin_repeat1	718..787	CDD:188963	34/90 (38%)
		SAM	719..781	CDD:197735	30/62 (48%)
		SAM_kazrin_repeat2	796..860	CDD:188966	31/69 (45%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	29/70 (41%)
		SAM	885..>934	CDD:197735	23/48 (48%)
PPFIA2	XP_016875568.1	SMC_N	<39..345	CDD:330553	30/156 (19%)
		SMC_N	<201..533	CDD:330553	76/366 (21%)
		SAM_liprin-alpha1,2,3,4_repeat1	898..968	CDD:188961	32/69 (46%)
		SAM_liprin-alpha1,2,3,4_repeat2	1022..1087	CDD:188964	31/64 (48%)
		SAM_liprin-alpha1,2,3,4_repeat3	1107..1178	CDD:188967	29/70 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810