DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and PPFIBP1

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_016875545.1	Gene:	PPFIBP1 / 8496	HGNCID:	9249	Length:	1036	Species:	Homo sapiens

Alignment Length:	881	Identity:	217/881 - (24%)
Similarity:	327/881 - (37%)	Gaps:	284/881 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   321 LRRLLE-LSTDGAVGGVDTAPEMEAVA--------------SGEGSAAKERIERLESELRSVKNQ 370
            ||.||| :.||...|.....|:..|..              .|.|...:||:.|||::..|:..|
Human    55 LRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQ 119

  Fly   371 --LLTMRLE---------------------------------RKKLRTDKSDLLGQVKQLCASLQ 400
              :||.::|                                 |..|.|.|.||:.::..|...|.
Human   120 VSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLT 184

  Fly   401 --EKE---------------QELRDFIR-----------NYQERVRETETTNAKISGDRDR-ERF 436
              ||:               ||:.| :|           .|:::::.|::..||:|..:.: .:.
Human   185 AVEKDRLDYEDKFRDTEGLIQEIND-LRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQM 248

  Fly   437 QLLKQARDEAERSL-----ALAQQLSARDLQLQRLQEQL-------------------------- 470
            |..||..::...||     :|.:||..::.:::||||:|
Human   249 QYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDENFKKKLKEKN 313

  Fly   471 -----------------QEARRQ---LTGCLSDQESLHSFAPLTPPSAA----------SGMLSQ 505
                             :|..|:   |..||:..:.:.....|......          |..:|.
Human   314 IEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKKGKDGEYEELLNSSSISS 378

  Fly   506 MAAASG-------------MG---------------------------------------GGLAG 518
            :..|.|             ||                                       ..|..
Human   379 LLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTP 443

  Fly   519 MRGTTEDSGRGNSLSAFSGSLSGGSGATAGDRNSCSNDSGLRNSSDRESTGGEL--NFSDG---- 577
            ...|:.:...||.:          .|||. |...|  |..|.:|..:.|:.|.|  ..|||
Human   444 KPETSFEENDGNII----------LGATV-DTQLC--DKLLTSSLQKSSSLGNLKKETSDGEKET 495

  Fly   578 ---------TCDNGPCITVDPDSISLVSSQNMYQFGTPKERS------------------PTLSP 615
                     ..::.|..|:.|......:|.:...|||.|.||                  |.|..
Human   496 IQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLDR 560

  Fly   616 LNSAA---YSRSVEQLGSPVDPEGPGNGAISRKFANASKS-------GPLGARNGRGGTWGSISR 670
            ..||:   .:.:.::....:|..    ||.||...:...|       .|...:..||     |.:
Human   561 KRSASAPTLAETEKETAEHLDLA----GASSRPKDSQRNSPFQIPPPSPDSKKKSRG-----IMK 616

  Fly   671 VFAR-SRNKNKALSADGVTEYADYSWNPLTEEG-----YAEKLRLLREASQ------LPIDRWRA 723
            :|.: .|:::...:.|.::|       |..:.|     ...:|...|:..|      :|..:|..
Human   617 LFGKLRRSQSTTFNPDDMSE-------PEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTK 674

  Fly   724 TQVLAWLEVALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEM 788
            .||..|| :..|:..|.......:.||:.||:.:..:||..||:.|.:|||||:||::.....|.
Human   675 EQVCNWL-MEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEE 738

  Fly   789 VRYPLITQLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIV 853
            ..:   .:|...|| |.||.|||||||...|.:..||.|||..::..:|.. |.|....|..||.
Human   739 TNH---GKLDFNWV-TRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLS-LKVVSVLHHLSIK 798

  Fly   854 HGIHVLRIVKYDRQTLAMRRVQSETVDTDPI-VWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLV 917
            ..|.||||..::...|..|.....|:....: .|||.|.:.|:||:||.|||.||:.|||||||:
Human   799 RAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLM 863

  Fly   918 VLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALI 953
            ||||.|:.:|||..|.|||:|.::||||.|.|:.||
Human   864 VLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLI 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	32/173 (18%)
		SAM_kazrin_repeat1	718..787	CDD:188963	23/68 (34%)
		SAM	719..781	CDD:197735	23/61 (38%)
		SAM_kazrin_repeat2	796..860	CDD:188966	27/63 (43%)
		SAM	805..860	CDD:197735	23/54 (43%)
		SAM_kazrin_repeat3	882..953	CDD:188969	40/71 (56%)
		SAM	885..>934	CDD:197735	30/48 (63%)
PPFIBP1	XP_016875545.1	SMC_N	<47..352	CDD:330553	59/297 (20%)
		SAM_liprin-beta1,2_repeat1	669..732	CDD:188962	23/63 (37%)
		SAM_liprin-beta1,2_repeat2	743..805	CDD:188965	27/63 (43%)
		SAM_liprin-beta1,2_repeat3	828..899	CDD:188968	40/70 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.880