DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and PPFIBP2

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001338782.2	Gene:	PPFIBP2 / 8495	HGNCID:	9250	Length:	928	Species:	Homo sapiens

Alignment Length:	1032	Identity:	273/1032 - (26%)
Similarity:	398/1032 - (38%)	Gaps:	278/1032 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 AGHLAQAAGPAHNAPSSGSALNAVDKRNANLSE---------PDQDLPPNLNVNLSPNPSLALGA 264
            |.|..:||....:...:|:      |..|:||:         |...:.|...::|..:..|||..
Human     5 ASHALEAALEQMDGIIAGT------KTGADLSDGTCEPGLASPASYMNPFPVLHLIEDLRLALEM 63

  Fly   265 PHSPTSAASAALLLLESCDGN---------RNDESRFHHLHSAPRPEATMKLREENDRLNAELLR 320
            ...|...|:    ||....|.         ....|:.:| |||...|.   .:|...||..:...
Human    64 LELPQERAA----LLSQIPGPTAAYIKEWFEESLSQVNH-HSAASNET---YQERLARLEGDKES 120

  Fly   321 LRRLLELSTDGAVGGVDTAPEMEAVASGEGSAAKERIERLESELRSVKNQLLTMRLERKKLRTDK 385
            |...:.:.||......:...::|....|.........|.|:.||           |.|..|.|.|
Human   121 LILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQEL-----------LSRTSLETQK 174

  Fly   386 SDLLGQVKQLCASL--QEKEQ-ELRDFIRNYQERVRETETTNAKISGDRDRERFQL---LKQARD 444
            .||:.:|.:|...|  .|||| |..:..|..:|.::|......|:. :.:.||.|.   ||..:.
Human   175 LDLMTEVSELKLKLVGMEKEQREQEEKQRKAEELLQELRHLKIKVE-ELENERNQYEWKLKATKA 238

  Fly   445 EAERSLALAQQLSARDLQLQRLQEQL---------------QEARR------------------- 475
            |..:   |.:|::.:|.:::||..||               ||.:|
Human   239 EVAQ---LQEQVALKDAEIERLHSQLSRTAALHSESHTERDQEIQRLKMGMETLLLANEDKDRRI 300

  Fly   476 -QLTGCLSDQESLHSFAPLTP-PSAASGMLSQMAAASGMGGGLAGMRGTTED---------SGRG 529
             :|||.|:....:.....:|. ||..:..:::....    ||.:....|.:|         ..|.
Human   301 EELTGLLNQYRKVKEIVMVTQGPSERTLSINEEEPE----GGFSKWNATNKDPEELFKQEMPPRC 361

  Fly   530 NSLSAFSGSLSGGSGATAGDRN-SCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDP-DSI 592
            :|.:.....|...|..|...:. |||.:. ||:.|..:...|          |.|...::| ||.
Human   362 SSPTVGPPPLPQKSLETRAQKKLSCSLED-LRSESVDKCMDG----------NQPFPVLEPKDSP 415

  Fly   593 SLVSSQNMYQFGTPKERSPTL-------SPLNSAAYS--------------------RSVEQLGS 630
            .|.           :.:.|||       :|...||.|                    |||   .:
Human   416 FLA-----------EHKYPTLPGKLSGATPNGEAAKSPPTICQPDATGSSLLRLNRGRSV---SA 466

  Fly   631 PV--DPE-GPGNGAISRKFANAS---KSGPL------GARNGRG--GTWGSISRVFARSRNKNKA 681
            ||  |.| |..:.|:....::.|   :|||.      |.||.:|  ..||.|.|
Human   467 PVLGDTESGWDDTAVVNDLSSTSSGTESGPQSPLTPDGKRNPKGIKKFWGKIRR----------- 520

  Fly   682 LSADGVTEYADYSWNPLTEEGYAE------------KLRLLREA------SQLPIDRWRATQVLA 728
                  |:..::..:.|   |.||            :|...|::      :..|..:|...:|.|
Human   521 ------TQSGNFYTDTL---GMAEFRRGGLRATAGPRLSRTRDSKGQKSDANAPFAQWSTERVCA 576

  Fly   729 WLEVALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPL 793
            ||| ..|:.||.....:.|.||..||.....::|..||:.||:|||||.||::.....:..:..|
Human   577 WLE-DFGLAQYVIFARQWVSSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINTKQEEKSAL 640

  Fly   794 ITQLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHV 858
               |.|.|| |.||.|||||||.:.|.:|.||.|||..|:..:| .||.||.:.|..||...|||
Human   641 ---LDHIWV-TRWLDDIGLPQYKDQFHESRVDRRMLQYLTVNDL-LFLKVTSQLHHLSIKCAIHV 700

  Fly   859 LRIVKYDRQTLAMRRVQSETVDTDPIV-WTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPS 922
            |.:.|::...|..|......:....:| |:|.|.:.|:||:||.|||.||:.|||||||::|||.
Human   701 LHVNKFNPHCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPR 765

  Fly   923 FSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPG-------GLQ 980
            |:|||:|..|.|||.|.::||||.|:|:|||.|......:...:.....|||...       |..
Human   766 FTGDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKREKMASPAYTPLTTTAKVRPRKLGFS 830

  Fly   981 HYATTDRRSSGNLRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNST------SPTPSYSSSEG 1039
            |:        ||:|                          :..|..||      .|:...|.|.
Human   831 HF--------GNIR--------------------------KKKFDESTDYICPMEPSDGVSDSH- 860

  Fly  1040 GGGIYATIGHQYPNP-----HTNLQQQHYHH--FLPPPTTAPPPIPSAGGIYSHGPP 1089
              .:|:  |::..:|     ...|.|..:.|  |...|.|...|.    .:.|..||
Human   861 --RVYS--GYRGLSPLDAPELDGLDQHQWKHMNFDAGPETMDTPT----RLSSQAPP 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	27/98 (28%)
		SAM_kazrin_repeat1	718..787	CDD:188963	26/68 (38%)
		SAM	719..781	CDD:197735	26/61 (43%)
		SAM_kazrin_repeat2	796..860	CDD:188966	33/63 (52%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	41/71 (58%)
		SAM	885..>934	CDD:197735	30/49 (61%)
PPFIBP2	NP_001338782.2	SMC_prok_B	59..>317	CDD:274008	65/280 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	356..376		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..451		5/25 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..511		7/29 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	538..564		2/25 (8%)
		SAM_liprin-beta1,2_repeat1	566..629	CDD:188962	26/63 (41%)
		SAM_liprin-beta1,2_repeat2	640..702	CDD:188965	34/66 (52%)
		SAM_liprin-beta1,2_repeat3	725..796	CDD:188968	41/70 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7126
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.880