DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Ppfia3

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_084017.2	Gene:	Ppfia3 / 76787	MGIID:	1924037	Length:	1194	Species:	Mus musculus

Alignment Length:	1049	Identity:	278/1049 - (26%)
Similarity:	401/1049 - (38%)	Gaps:	311/1049 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   224 SSGSALNAVD---KRNANLSEPDQDLPPNLNVN-LSP-------------------------NPS 259
            |:..|||..|   :|.:.|.||.:|.......| |.|                         ...
Mouse   191 SNQEALNLRDQLSRRRSGLEEPGKDGDGQTLANGLGPVGESNRRTAELEEALERQRAEVCQLRER 255

  Fly   260 LA------------LGAPHSPTSAASAALLLLE----SCDGNRND-ESRFHHLH----SAPRPEA 303
            ||            ||..|.....|..|...|:    .....|.| |.|...|.    ||.| ||
Mouse   256 LAVLCRQMSQLEEELGTAHRELGKAEEANSKLQRDLKEALAQREDMEERITTLEKRYLSAQR-EA 319

  Fly   304 TMKLREENDRLNAELL-----------RLRRLLELSTDG------AVGGVDTAPEMEAVASGEGS 351
            | .|.:.||:|..||.           :.|:|.|...|.      .:...:|.||:||..:...:
Mouse   320 T-SLHDANDKLENELASKESLYRQSEEKSRQLAEWLDDAKQKLQQTLQKAETLPEIEAQLAQRVA 383

  Fly   352 AA----------KERIERLESELRSVKNQLLTMRLERKKLRTDKSDLLGQ-VKQLCASLQEKEQE 405
            |.          :||:.:||::|.. |||.|....:|:|:..|.:..|.: |.:|.:...|:.|
Mouse   384 ALNKAEERHGNFEERLRQLEAQLEE-KNQELQRARQREKMNDDHNKRLSETVDKLLSESNERLQ- 446

  Fly   406 LRDFIRNYQERVRETETTNAKISGDRDRERFQLLKQARDEAERSLALAQQLSARDLQLQRLQEQL 470
                 .:.:||:...|..|:.      .|....:|:.:||.   |...:||.|   :::|:|.::
Mouse   447 -----LHLKERMGALEEKNSL------SEEIANMKKLQDEL---LLNKEQLLA---EMERMQMEI 494

  Fly   471 QEAR--------RQLTGCLSDQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSG 527
            .:.|        |.|.|  |..|..:|.||..|..|.   |....|.||..|......|..::|.
Mouse   495 DQLRGRPPSSYSRSLPG--SALELRYSQAPTLPSGAP---LDPYGAGSGRAGKRGRWSGAKDESS 554

  Fly   528 RGNSLSA--------FSGSLSG-----GSGATAGDRNSCSNDSGLRN------------------ 561
            :....||        |.|.|.|     ..|....:..|.|..:.::.
Mouse   555 KDWDRSAPAGSIPPPFPGELDGSDEEEAEGMFGAELLSPSGQADVQTLAIMLQEQLEAINKEIKL 619

  Fly   562 -SSDREST---GGELN---FSDG---------TCDNGPCITVD---------------------- 588
             ..::|:|   ..||.   .|.|         :|...|.:|..
Mouse   620 IQEEKETTEQRAEELESRVSSSGLDSLGRYRSSCSLPPSLTTSTLASPSPPSSGHSTPRLAPPSP 684

  Fly   589 ----PDSISLVSSQNMYQFGTPKERSPTL-------SPLNSAAYSRSVE----QLGSPVDPEGPG 638
                .|..:.||.:   :.|.|:...|.:       :| .||...|..:    |.|||.|...|
Mouse   685 AREGTDKTNHVSKE---EAGVPRGEGPAVPGDTPPPTP-RSARLERMAQALALQAGSPEDGAPP- 744

  Fly   639 NGAISRKFANASKSGP--LGARNGRGGTWGSISRVFARSRN------KNKALSADGVTEYADYSW 695
                     ..|:|.|  |.....|.....||.|:|.:...      ..:::|..|.......:.
Mouse   745 ---------RGSESTPDSLHKAPKRKSIKSSIGRLFGKKEKGRMGPPGRESVSLAGTPSDETLAT 800

  Fly   696 NPLTEEGYAE-------------KLRLLREASQ--LPIDRWRATQVLAWLEVALGMPQ-YSARCA 744
            :||   |.|:             |..||.||.:  ||...|....|::|||:.:|||. |.|.|.
Mouse   801 DPL---GLAKLTGPGDKDRRNKRKHELLEEACRQGLPFAAWDGPTVVSWLELWVGMPAWYVAACR 862

  Fly   745 ENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEE------------QRRP---------EM 788
            .|||||.::..|:|.|::..:|:::|:||.||||||:|            .|.|         ||
Mouse   863 ANVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASSRTPTGNVWMTHEEM 927

  Fly   789 VRYPLITQ----------------LGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKEL 837
            ......|:                :.|.||..:|||.:|||||...|::|||||||||.|:||||
Mouse   928 ESLTAATKPETKEISWEQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLNKKEL 992

  Fly   838 EKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGE 902
            ...|.:...||:.|:.:||..|:.:.|||:.|..||.:|:|...|.:||:|:|.:.||..:.|.|
Mouse   993 RGQLKMVDSFHRVSLHYGIMCLKRLNYDRKDLERRREESQTQIRDVMVWSNERVMGWVSGLGLKE 1057

  Fly   903 YADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSG 967
            :|.||.:|||||.|:.|:.:|....:|..|.||......|:.|..||..||     :||
Mouse  1058 FATNLTESGVHGALLALDETFDYSDLALLLQIPTQNAQARQLLEKEFSNLI-----SLG------ 1111

  Fly   968 CGVVPLTGPGGLQHYATTDRRSSGNLRISAWKGSQS-SLSKAFRFNSKPHRTGDRSSFGNSTSPT 1031
                             ||||...:   ||...|:| |..|.||.......|.|     ::....
Mouse  1112 -----------------TDRRLDED---SAKSFSRSPSWRKMFREKDLRGVTPD-----SAEMLP 1151

  Fly  1032 PSYSSSEGG 1040
            |::.|:..|
Mouse  1152 PNFRSAAAG 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	26/106 (25%)
		SAM_kazrin_repeat1	718..787	CDD:188963	32/90 (36%)
		SAM	719..781	CDD:197735	28/62 (45%)
		SAM_kazrin_repeat2	796..860	CDD:188966	32/79 (41%)
		SAM	805..860	CDD:197735	29/54 (54%)
		SAM_kazrin_repeat3	882..953	CDD:188969	28/70 (40%)
		SAM	885..>934	CDD:197735	21/48 (44%)
Ppfia3	NP_084017.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Smc	<151..496	CDD:224117	79/325 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..233		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..588		18/69 (26%)
		VirB10_like	535..>747	CDD:421703	40/225 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	624..817		40/209 (19%)
		SAM_liprin-alpha1,2,3,4_repeat1	835..905	CDD:188961	30/69 (43%)
		SAM_liprin-alpha1,2,3,4_repeat2	952..1017	CDD:188964	33/64 (52%)
		SAM_liprin-alpha1,2,3,4_repeat3	1037..1108	CDD:188967	28/70 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1157..1194		1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810