DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and ppfibp2

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_031756364.1	Gene:	ppfibp2 / 733904	XenbaseID:	XB-GENE-1013068	Length:	1015	Species:	Xenopus tropicalis

Alignment Length:	879	Identity:	224/879 - (25%)
Similarity:	314/879 - (35%)	Gaps:	290/879 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 LESCDGNRNDESRFHHLHSAPRPEATMKLREENDRLNAELLRLRRLLELSTDGAVGGVDTAPEME 343
            ||||       ...|||          ||....:.|..|||. |..||...      :|...|:.
Frog   138 LESC-------VEEHHL----------KLNATEEMLQQELLS-RTSLETQK------LDLMAELS 178

  Fly   344 AVASGEGSAAKERI--ERLESELRSVKN-------QLLTMRLE------RKKLRTDKSDLL---- 389
            .:........||:|  |...|:..||.|       |:..::||      .::.:..:|||:
Frog   179 NLKIKLAGLEKEKINYEDSHSKAESVVNLINELQEQMCKLQLEINNKIHERQAKGSQSDLIIKSP 243

  Fly   390 ---------GQVKQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGDRDRERFQ-LLKQARD 444
                     ...:|.|...:.||:.|:: ::|.:.:|.|.|         .:|.::: .||..:.
Frog   244 YASTLCLTESPQQQHCPGCEGKEELLQE-LKNLKMKVEELE---------NERTQYEWKLKATKA 298

  Fly   445 EAERSLALAQQLSARDLQLQRLQEQL-------------------------QEARRQLTG----C 480
            |..:   |.:||:.:|.:::||:.|:                         ||.:|...|    .
Frog   299 EIAQ---LQEQLALKDAEIERLKSQISSRTIAQNESSEREEVFRRRIKEKHQEVQRLKLGMETLL 360

  Fly   481 LSDQESLHSFAPLTPPSAASGMLSQ--------MAAASGMGGGLAGMRGTTEDSGRGNSLSAFSG 537
            .:::|..|....||.      :|||        |||.:              .|.|..|||
Frog   361 AANEEKDHRIEELTL------LLSQYRRVKSFVMAAHA--------------SSERMLSLS---- 401

  Fly   538 SLSGGSGATAGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDN----GPCITVDPDSISLVSSQ 598
                                   :..:.|:|..:||..|...:.    .||....|...|.:.:.
Frog   402 -----------------------SEEEVEATLRKLNPVDNQTNELPKPEPCQGDPPPITSTLPAP 443

  Fly   599 NMYQFGT---------------------PKERSPTLSPLNSAAYSRSVEQLGSPVDPEG------ 636
            |..|..|                     |::...:|..|..|.....||.....:.||.
Frog   444 NNLQTSTSPAEPCPASWEETPEYKNRIIPRKLCSSLEDLQCAEKHVDVEVTDPVLTPESKAHIED 508

  Fly   637 ------PG-------NGA-----------------------------------ISRKFAN----- 648
                  ||       |||                                   |..|..|
Frog   509 HRYQTLPGKLPRPNQNGAHDPHRNPPSQNLLHVSSATNGIHDSYITRSISAPVIGEKEHNLDITF 573

  Fly   649 ---------------------ASKSGPLGARNGRGGTWGSISRV---------FARSRNKNKALS 683
                                 .||..|.|.:.    .||.|.|.         .|.|..|...|.
Frog   574 TSNDLSLSSGTDSGPQSPLSPESKKSPKGIKK----FWGRIRRTPSGNFSMDGAALSEFKRGGLR 634

  Fly   684 ADGVTEYADYSWNPLTEEGYAEKLRLLREASQLPIDRWRATQVLAWLEVALGMPQYSARCAENVK 748
            |......:....|           |:.......|..:|...||..||| .||:.||.....:.:.
Frog   635 ATAGPRLSRTKDN-----------RIKNSDCNAPFAQWSNEQVCNWLE-DLGLGQYIIFARQWIS 687

  Fly   749 SGKVLLELNDVELEAGLGLAHPMHRKKLRLAIE--EQRRPEMVRYPLITQLGHTWVATEWLPDIG 811
            ||..||......||..||:.||:|||||::||.  ..::.|.     ..||.|.|| |.||.|||
Frog   688 SGHTLLMATPQALEKELGIKHPLHRKKLQMAINAINSKKEEK-----SGQLDHIWV-TRWLDDIG 746

  Fly   812 LPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQS 876
            ||||.:.|..|.||.:||..|:..:| .||.||.:.|..||...||||...|::...|..|....
Frog   747 LPQYKDQFHDSRVDGKMLQFLTVNDL-LFLKVTSQLHHLSIKCAIHVLHANKFNAHCLRRRPADE 810

  Fly   877 ETVDTDPIV-WTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNI 940
            ..:....:| |:|.|.:.|:||:||.|||.||:.|||||||::|||.|:.||:|..|.||..|.:
Frog   811 NNISPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFNSDTLAMLLNIPTQKTL 875

  Fly   941 IRRHLNTEFDALILPARATLGQGIRSGCGVVPLT 974
            :||||.|.|:.||.|......:.|.......||:
Frog   876 LRRHLATNFNLLIGPEAQQEKREIMDSTSFSPLS 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	25/123 (20%)
		SAM_kazrin_repeat1	718..787	CDD:188963	27/70 (39%)
		SAM	719..781	CDD:197735	26/61 (43%)
		SAM_kazrin_repeat2	796..860	CDD:188966	33/63 (52%)
		SAM	805..860	CDD:197735	27/54 (50%)
		SAM_kazrin_repeat3	882..953	CDD:188969	38/71 (54%)
		SAM	885..>934	CDD:197735	29/49 (59%)
ppfibp2	XP_031756364.1	Smc	<100..417	CDD:224117	75/362 (21%)
		SAM_liprin-beta1,2_repeat1	658..721	CDD:188962	27/63 (43%)
		SAM_liprin-beta1,2_repeat2	732..794	CDD:188965	33/63 (52%)
		SAM_liprin-beta1,2_repeat3	817..888	CDD:188968	38/70 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920