Protein Alignment Liprin-gamma and ppfia3

DIOPT Version :10

• Sequence 1: NP_001097414.1
• Gene: Liprin-gamma / 37552
• FlyBaseID: FBgn0034720
• Length: 1152
• Species: Drosophila melanogaster
• Sequence 2: XP_003198161.2
• Gene: ppfia3 / 567230
• ZFINID: ZDB-GENE-100311-3
• Length: 1226
• Species: Danio rerio
• Alignment Length: 1310
• Identity: 312/1310 - (23%)
• Similarity: 469/1310 - (35%)
• Gaps: 453/1310 - (34%)

  Fly    65 IRPLLSLDSSVTA----STSSGATGSGGGGAPAKPSPLVLASKRDLTPSNESSSSPSSSNGSNQT 125
            :.|.:|.|....|    |:.:|..|..||||.......   ..|:....:|..|:     |:.::
Zfish     5 VMPTISEDGRGGAGGGPSSPAGGGGGMGGGAGGMGGGY---GGREARGGDEGGST-----GNLES 61

  Fly   126 LTPPMTADNQPLQQQLQHHQHRSPAYPGKPAEAAGGVP--------QQQQQQQQLPNGIGSSHCN 182
            |...|..:.:.|.:.|:..|           |:.|...        ::...|:||...:......
Zfish    62 LMVNMLTERERLLESLRETQ-----------ESLGTAQLRLRELGHEKDSLQRQLSIALPQEFAV 115

  Fly   183 SNSNGISSTCNS---------GTAMIHANNSNLIAAGHL-----------------AQAAGPAHN 221
            ....  .:.|..         .......||:.|:.. ||                 .||..|| .
Zfish   116 LTKE--LNVCREQLLEREEEIAELKAERNNTRLLLE-HLECLVSRHERSLRMTVVKRQAQSPA-G 176

  Fly   222 APSSGSALNAVDKRNANLSEPDQDLPPNLNVNL------------SPNPSLAL------------ 262
            ..|....|.|:.....:....|:.:...|.|.|            |.|..|:|
Zfish   177 VSSEVEVLKALKSLFEHHKALDEKVRERLRVALERVAVLEEELESSTNEVLSLRDQIKRRERGLD 241

  Fly   263 ----GAPHSPTSAASAALLLLESCDGNRNDESRFHHLHSAPRPEATMKLREENDRLNAELLRLRR 323
                ..|:.|:|       :|:..:.:|..|.                   |.:|..|||.:|:.
Zfish   242 NGKERLPNGPSS-------ILDDGEIDRQREG-------------------EIERQRAELSQLKE 280

  Fly   324 LLELSTDGAVGGVD---TAPEMEAVASGEGSA---------------AKERI------------- 357
            .|.|.. ..||.::   |....|...|.|.:.               .:|||
Zfish   281 RLALMC-RQVGEIEEQLTTARRELAKSEEANQKLQRDVKEALCQREDMEERITTLERRYLSAQRE 344

  Fly   358 --------ERLESELRS---------VKNQLLTMRLE--RKKLR--TDKSDLLGQV--------- 392
                    ::||:||.|         .||:.|..||:  ::||:  ..:::.|.::
Zfish   345 ATSLHDIKDKLENELASKESLYRQSEEKNRQLQERLDDAKQKLQQTLQRAETLPEIEAQLAQRVA 409

  Fly   393 ----------------KQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGDRDR------ER 435
                            :||.|.|:||.|||    :..::|.|..:..|.::|...|:      ||
Zfish   410 ALNKAEERHGNFEERLRQLEAQLEEKNQEL----QRARQRERMNDEHNKRLSDTVDKLLSESNER 470

  Fly   436 FQL-LKQARDEAERSLALAQQLSARDLQLQRLQEQLQEARRQLTGCLSDQESLH----------- 488
            .|| ||:.....|...||:::|:    .::::|:.|...:.||   :::.|.|.
Zfish   471 LQLHLKERMAALEEKNALSEELA----NMKKIQDDLLANKDQL---IAELERLQLELDQLRGRPG 528

  Fly   489 -SFAPLTPPSAASGMLSQMAAASGMGG-------GLAGMRGTTEDSGRG------NSLSAFSGSL 539
             |::...|.||.....||...:...|.       |..|..|....:.||      ...|.:....
Zfish   529 SSYSRSLPGSALELRYSQGGGSLPAGSTTHLEHYGNTGTGGVVRRTHRGRWSGAREDASKYGDWE 593

  Fly   540 SG---GSGATAGDRNSCSNDSGLRNSSDREST-GGELNFSDGTCD-------------------- 580
            ||   |||...|..:.||:|     ..|||:. |.||....|..|
Zfish   594 SGALLGSGFEGGVEDRCSDD-----EEDRETLFGSELLSPSGQTDVQTLAIMLQEQLEAINKEIK 653

  Fly   581 -------------------------NGPCITVDPDSI------------SLVSSQNMYQFGTPKE 608
                                     :||  .:.|.|:            ||.||    ...:|..
Zfish   654 LIQEEKESTELRAEEIESRVSSVALDGP--PIPPTSLGRDSTGRGFIPPSLTSS----TLASPSP 712

  Fly   609 RS-----PTL--SPL------NSAAYSRSVEQLGS--PVDPEG----------PGNGAI---SRK 645
            .|     |.|  ||.      |:....||:..|.|  |..|..          |  ||:   ||:
Zfish   713 PSSGHSTPRLPHSPARETDRQNNKEDDRSLALLDSTPPPTPRALRLDRMTHTHP--GALLDDSRE 775

  Fly   646 FANASKSG--------PLGARNGRGGTWGSISRVFARSRNKNKALSADGVTEYADYSWNPLTEEG 702
            |.:.|..|        .|...:.:.....||.|:|.:   |:|........|....:..|..:.|
Zfish   776 FRSLSADGSSSNSSQDSLHKASKKKSIKSSIGRLFGK---KDKVRMGQPGRESTSLASTPSDDLG 837

  Fly   703 YAEKL-------------------RLLREASQ--LPIDRWRATQVLAWLEVALGMPQ-YSARCAE 745
            ..:.|                   .||.||.:  ||...|....|::|||:.:|||. |.|.|..
Zfish   838 TVDPLGLTKMAGPVDKDRRSKKKHELLEEACRQGLPFASWDGPTVVSWLELWVGMPAWYVAACRA 902

  Fly   746 NVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQ--------------------------- 783
            |||||.::..|:|.|::..:|:::|:||.||||||:|.
Zfish   903 NVKSGAIMANLSDTEIQREIGISNPLHRLKLRLAIQEMVSLTSPSAPASTRSSTSNVWMTHAEME 967

  Fly   784 -----RRPEM--VRYPLITQLG---HTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELE 838
                 .:||:  :.:..|...|   |.||..:|||.:|||||...|::|||||||||.|:||||.
Zfish   968 SLTAATKPELKEISWDQILAYGDMNHEWVGNDWLPSLGLPQYRSYFMESLVDARMLDHLTKKELR 1032

  Fly   839 KFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEY 903
            ..|.:...||:.|:.:||..|:.:.|||:.|..||.:|:..:.|.:||:|:|.:.||:||.|.||
Zfish  1033 GQLKMVDSFHRVSMHYGIMCLKRLNYDRKELERRRDESQHQNKDVMVWSNERVMCWVQSIGLKEY 1097

  Fly   904 ADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGC 968
            ||||.:|||||.|:.|:.:|....:|..|.||......|:.|..|:::||     ::|
Zfish  1098 ADNLTESGVHGALLALDDTFDYTDLALLLQIPNQNTQARQLLEKEYNSLI-----SMG------- 1150

  Fly   969 GVVPLTGPGGLQHYATTDRRSSGN-----LRISAWKGSQSSLSKAFRFNSKPHRTGDRS-----S 1023
                            |:||...:     .|..:|:       |.||.......|.|.|     :
Zfish  1151 ----------------TERRPDEDGTKTFTRSPSWR-------KMFREKDLRGVTSDSSETLPAN 1192

  Fly  1024 FGNSTSPTPS 1033
            |..|...|||
Zfish  1193 FRASAISTPS 1202

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	COG4372	<346..>460	CDD:443500	42/194 (22%)
		SAM_kazrin_repeat1	718..787	CDD:188963	30/101 (30%)
		SAM_kazrin_repeat2	796..860	CDD:188966	33/66 (50%)
		SAM_kazrin_repeat3	882..953	CDD:188969	31/70 (44%)
ppfia3	XP_003198161.2	Smc	77..>670	CDD:440809	124/650 (19%)
		SAM_liprin-alpha1,2,3,4_repeat1	874..944	CDD:188961	30/69 (43%)
		SAM_liprin-alpha1,2,3,4_repeat2	991..1056	CDD:188964	33/64 (52%)
		SAM_liprin-alpha1,2,3,4_repeat3	1076..1147	CDD:188967	31/70 (44%)