DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Liprin-gamma and ppfia2

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_009298674.1	Gene:	ppfia2 / 566597	ZFINID:	ZDB-GENE-030131-7905	Length:	1274	Species:	Danio rerio

Alignment Length:	925	Identity:	241/925 - (26%)
Similarity:	354/925 - (38%)	Gaps:	263/925 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 EATMKLREENDRLNAELLRLRRLLELSTDGAVGGVDTAPEMEAVASGEGSAAKERIERLESELRS 366
            ||.::..||.:|...|.|   .|.|......:...:|.||:||          |..:|:.:..:|
Zfish   351 EAFLRQMEEKNRQLQERL---ELAEQKLQQTMRKAETLPEVEA----------ELAQRIAALTKS 402

  Fly   367 -VKNQLLTMRLERKKLRTDKSDLLGQVKQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGD 430
             ::.:|..|....:|.......:..:::.|...|:||.|||    ...::|.:..|..|.::|..
Zfish   403 DIEAKLQDMNSSLRKAEERHGSIEERMRHLEGQLEEKNQEL----LRARQREKMNEEHNKRLSDT 463

  Fly   431 RDR------ERFQL-LKQARDEAERSLALAQQLSARDLQLQ-------RLQEQLQEARRQLTGCL 481
            .||      ||.|| ||:.....|....|.|...:...||:       .:.|::::.|.:|
Zfish   464 VDRLLTESNERLQLHLKERMAALEEKNVLIQDSESYRKQLEDSIQEKSHISEEMEKLRSEL---- 524

  Fly   482 SDQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLA------------------GMRGTTEDSGR 528
             ||..|.: ..||.|:.:...|..........|.||                  |..|...:..:
Zfish   525 -DQYRLRA-GSLTEPTLSRSHLDASGDLRFSLGSLAETQSDHYRSTKVIRRPRRGRMGLRREEQK 587

  Fly   529 GNSL------SAFSGSLSGG--------SGATAGDRNSCSNDSGLRNSS---------------- 563
            ..||      |...|.|.|.        |.....||.:..:...|.:.|
Zfish   588 AKSLGEHEWRSQQLGVLGGHPFESDTEMSDIDDDDRETLFSSMDLLSPSGHSDAQTLAMMLQEQL 652

  Fly   564 ------------DRESTGGELNFSDGTCDN------------------GPCITVDPDSISLVSSQ 598
                        ::|||  ||...:  .:|                  |..||....:.||.||.
Zfish   653 DAINKEIRLIQEEKEST--ELRAEE--IENRVASVSLEGLNLARVHHPGTSITASATASSLASSS 713

  Fly   599 NMYQFGTPK--ERSPTLSPLNSAAYSRSVEQLG---------------SPVDPEGPGNGA----- 641
            ......|||  .|||          :|.:|::|               :.||.:|..:.|
Zfish   714 PPSGHSTPKLTPRSP----------ARDMERMGVMTLPSDLRKHRRKIAAVDEDGREDKATIKCE 768

  Fly   642 ---------------------------------ISRKFANASKSGPLGARNGRGGTWGSISRVFA 673
                                             .|...:.||....|..:..:.|...||.|:|.
Zfish   769 TSPPPTPRQVRMTHTLPASSHNDARLTAALETEASALSSVASSQDSLHKQPKKKGIKSSIGRLFG 833

  Fly   674 RSRNKNKALSAD------GVTEYADYSWNPLTEEG--------YAEKLR--------LLREASQ- 715
            :   |.||....      |..:..:.|...|..:.        .|||.|        ||.||.:
Zfish   834 K---KEKARLGQLGKEIMGPGQVGNVSDPELMGQDIAVGKLGTQAEKDRRLKKNGHELLEEARRK 895

  Fly   716 -LPIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRL 778
             ||..:|....|:||||:.||||. |.|.|..|||||.::..|:|.|::..:|:::|:||.||||
Zfish   896 GLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRL 960

  Fly   779 AIEE------------QRRP-----------EMVRYPLITQ----------------LGHTWVAT 804
            ||:|            .|.|           |.:..|..|:                :.|.|:..
Zfish   961 AIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMETMAAPSKTKSDSEEGSWSQTLAYGDMNHEWIGN 1025

  Fly   805 EWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTL 869
            ||||.:|||||...|::.||||||||.|:||:|...|.:...||:.|:.:||..|:.:.|||:.|
Zfish  1026 EWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKKLNYDRKEL 1090

  Fly   870 AMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGI 934
            ..||..|:....|.:||:|:|.||||:||.|.:||:.|.:|||||.|:.|:.:|...::|..|.|
Zfish  1091 ERRRESSQHDIRDVLVWSNERVIRWVQSIGLRDYANILLESGVHGALIALDDNFDYSSLALLLQI 1155

  Fly   935 PPSKNIIRRHLNTEFDALILPARATLGQGIR-SGCGVVPLTGPGGLQHYATTDRRSSGNLRISAW 998
            |......|:.|..|::.|:     .||...| ..|......||...:.:...|...     ||..
Zfish  1156 PNQNTQARQILEREYNNLL-----ALGTERRLDECDEKDFRGPSWRRQFPPRDVHG-----ISMM 1210

  Fly   999 KGSQSSLSKAFRFNS 1013
            .||..:|...||..:
Zfish  1211 PGSAETLPAGFRLTA 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	24/102 (24%)
		SAM_kazrin_repeat1	718..787	CDD:188963	34/92 (37%)
		SAM	719..781	CDD:197735	30/62 (48%)
		SAM_kazrin_repeat2	796..860	CDD:188966	30/79 (38%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	30/70 (43%)
		SAM	885..>934	CDD:197735	24/48 (50%)
ppfia2	XP_009298674.1	Taxilin	234..526	CDD:286771	47/196 (24%)
		Angiomotin_C	305..449	CDD:289044	27/114 (24%)
		FadA	411..522	CDD:286488	27/114 (24%)
		SAM_liprin-alpha1,2,3,4_repeat1	899..969	CDD:188961	32/69 (46%)
		SAM	899..965	CDD:197735	31/65 (48%)
		SAM_liprin-alpha1,2,3,4_repeat2	1018..1083	CDD:188964	31/64 (48%)
		SAM	1026..1082	CDD:197735	29/55 (53%)
		SAM_liprin-alpha1,2,3,4_repeat3	1103..1174	CDD:188967	30/70 (43%)
		SAM	1104..1175	CDD:197735	30/75 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810