DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Liprin-gamma and ppfibp1a

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_005164718.1	Gene:	ppfibp1a / 565020	ZFINID:	ZDB-GENE-041210-298	Length:	880	Species:	Danio rerio

Alignment Length:	873	Identity:	230/873 - (26%)
Similarity:	333/873 - (38%)	Gaps:	220/873 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 QQLPNGIGSSHCNSNSNGISSTCNSGTAMIHANNSNLIAAGHLAQAAGPAHNAPSSGS--ALNAV 232
            :|:...|..|...:.:||:.. |.|.|                         :|..||  ||:.:
Zfish    14 EQMDGIIAGSKAMTYTNGLFD-CQSPT-------------------------SPFLGSIRALHLL 52

  Fly   233 DKRNANLSEPDQDLPPNLNVNLSPNPSLAL-----GAPHSPTSAASAALLLLESCDGNRNDE--- 289
            :...|.|...|.:...|:...:|...:..|     |...:...:|:..|:..|......:|:
Zfish    53 EDLRAALDLMDPEEKENMRSQVSETTAEGLMEWLQGRLTNGHGSAAGDLVHQERLSRLESDKECL 117

  Fly   290 ---------------SRFHHLHSAPRPEATMKLREENDRLNAELLRLRRL----LELSTDGAVGG 335
                           .:...|.|: ..|..|||....:.|..|||....|    |||.|:  :..
Zfish   118 VLQVSVLTDQVEVQGEKIRDLDSS-LEEHHMKLNATEELLQQELLSRSTLEAEKLELLTE--ISS 179

  Fly   336 VDTAPEMEAVASGEGSAAKERIERLESELRSVKNQLLTMRLER----KKLRTDKSDLLGQVKQLC 396
            :..     .:|:.||..  ...|.|..:::.::.:|.:|..||    :.|.:.|.:|:...||
Zfish   180 LKL-----KLAAAEGDC--RECEGLFQDVKDLRLKLTSMENERQHYERSLISTKEELISLQKQ-- 235

  Fly   397 ASLQEKEQELRDFIRNYQER-VRETETTNAKISGDRDRERFQLLKQARDEAERSLALAQQLSARD 460
              |:|:||.    .:..|:| |.||..|....|.:||.| .|.|:.|.:      :|......:|
Zfish   236 --LEEREQA----FKRIQDRGVPETLNTEQSQSKERDVE-VQRLRSAME------SLKATNEEKD 287

  Fly   461 LQLQRLQEQLQEARR---------QLTGCLSDQESLHSF-------------------------- 490
            .:::.||:.|...||         .|...|||:::....
Zfish   288 FRIKELQQSLIHYRRVQDIGKTVHVLKDNLSDEDTREGLCDSEMLSTGGTEETDEPQLIPCSELL 352

  Fly   491 --APLTP--------PSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGGSG- 544
              .|.||        .|..|.:.|.....:....|...:..|...|||..|..:.....|.|.|
Zfish   353 PEVPHTPTDSVSEVQQSERSPLTSSNEDEASKNRGFPSISPTQPSSGRNESFGSKKTRSSFGRGF 417

  Fly   545 -ATAGDRNSCSNDS---GLRNSSDRESTGGELNFSDGTCDNGPCITVDPDSISLVSSQNMYQFGT 605
             ...|::.:.|..|   |.:..::.....|.........|     |..||. ...|...|..||.
Zfish   418 FKIRGNKMTGSAPSLAEGEQKGTEHLDLAGVQTKKQKALD-----THSPDG-KKKSKGIMKLFGR 476

  Fly   606 PKERSPTLSPLNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGSISR 670
            .|....|.|.|:.:..|                      :|.........|.|.|    |   ||
Zfish   477 MKRSQSTSSDLDDSPDS----------------------EFQRGGVRATAGPRLG----W---SR 512

  Fly   671 VFARSRNK--NKALSADGVTEYADYSWNPLTEEGYAEKLRLLREASQLPIDRWRATQVLAWL-EV 732
            ...||.|.  |.|.|                                    ||...||..|| |.
Zfish   513 DLQRSNNNELNSAFS------------------------------------RWSKEQVCEWLQEQ 541

  Fly   733 ALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPLITQL 797
            .||:  |..:..:.:|||..||:.:..:.|..||:.||:|||||:||::.....:   ...:.:|
Zfish   542 GLGL--YMNQAQQWIKSGHTLLKASQHDWEKELGIRHPLHRKKLQLALQSLSSED---GDAMGKL 601

  Fly   798 GHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLG--VTRKFHQASIVHGIHVLR 860
            .:.|| |:||.|||||||...|.:..||.|||..::..:|   ||  |....|..||...|.|||
Zfish   602 DYNWV-TQWLDDIGLPQYKSQFDEGRVDGRMLHYMTVDDL---LGLKVGSVLHHLSIKRAIQVLR 662

  Fly   861 IVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSG 925
            :..||...|..|.:::.....:...|||.|.:.|:||:||.|||.||:.|||||||:||||.|:.
Zfish   663 LNGYDPNCLRRRPIENNATPAEICQWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNV 727

  Fly   926 DTMATALGIPPSKNIIRRHLNTEFDALI 953
            :|||..|.|||:|.::||||.|.|..||
Zfish   728 ETMALLLNIPPNKTLLRRHLATHFHLLI 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	28/100 (28%)
		SAM_kazrin_repeat1	718..787	CDD:188963	27/69 (39%)
		SAM	719..781	CDD:197735	27/62 (44%)
		SAM_kazrin_repeat2	796..860	CDD:188966	28/65 (43%)
		SAM	805..860	CDD:197735	24/56 (43%)
		SAM_kazrin_repeat3	882..953	CDD:188969	40/70 (57%)
		SAM	885..>934	CDD:197735	30/48 (63%)
ppfibp1a	XP_005164718.1	KASH_CCD	107..297	CDD:291334	51/214 (24%)
		SAM	526..590	CDD:197735	28/101 (28%)
		SAM_liprin-beta1,2_repeat1	526..589	CDD:188962	28/100 (28%)
		SAM_liprin-beta1,2_repeat2	600..662	CDD:188965	28/65 (43%)
		SAM	602..662	CDD:197735	27/63 (43%)
		SAM_liprin-beta1,2_repeat3	684..755	CDD:188968	40/70 (57%)
		SAM	687..754	CDD:197735	40/66 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920