DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and ppfibp2b

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_001313527.1	Gene:	ppfibp2b / 436635	ZFINID:	ZDB-GENE-040718-54	Length:	979	Species:	Danio rerio

Alignment Length:	905	Identity:	240/905 - (26%)
Similarity:	384/905 - (42%)	Gaps:	180/905 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 EAAGGVPQQQQQQQQLPNGIGSSHCNSNSNGISSTCNSGTAMIH-------------ANNSNLIA 208
            |...|..::...:.|||                  |::...::|             ::::|...
Zfish    59 ELQAGDEERHSLRSQLP------------------CSTAHTLLHWLDRGALSQVNHQSSSNNETY 105

  Fly   209 AGHLAQAAGPAHNAPSSGSAL-NAVDKRNANLSEPDQDLPPNLNVNLSPNPSLALGAPHSPTSAA 272
            ...||:..|...:.....|.| :.|:.:...:.:.:..|..:.:..:|....|.... .|.||..
Zfish   106 QERLARLEGDKESLVLQVSVLTDQVEAQGEKIRDLESSLEEHHHKLISTEEMLQQEL-FSRTSLE 169

  Fly   273 SAALLLLESC------------DGNRNDESRFHHLHSAPRPEATMKLREE--------NDRLNAE 317
            :..|.|::..            :.|..||...||     :.|:.:.|..|        .:.::..
Zfish   170 TQKLELMDEVSYLKLKLVGMEEEHNHIDEEDKHH-----KAESVVNLISELQEQMCKFQEEISNR 229

  Fly   318 LLRLRRLLELSTDGAVGGVDTAPEMEAVAS-GEGSAAKERI---ERLESELRSVKNQLLTMRLER 378
            :...|.|..|...|....:|.:|::...|| .|..:.:.|.   ..|..|||.:||::..:..|:
Zfish   230 IQEQRALESLGDSGTREALDQSPDVGLGASDAEDCSCRCRSGGENALLQELRLLKNKVEELEGEK 294

  Fly   379 ----KKLRTDKSDLLGQVKQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGDRDRERFQLL 439
                :||:..|:: :.:::||.|:   |:.|    |...|.::....|.|..|: :||:| .|.|
Zfish   295 SQYERKLKATKTE-IAKLQQLLAT---KDAE----IECLQNQLLSRGTINNDIT-ERDQE-LQRL 349

  Fly   440 K-------QARDEAERSLALAQQLSARDLQLQRLQE--QLQEARRQLTGCLSDQESL---HSFAP 492
            |       .|.:|.:|.:   ::|:....|.::|::  .|.:.......|.|.:|.|   .....
Zfish   350 KTGMETLIAANNEKDRHI---EELNVLLGQYRKLKDGLALSQVNNDSLLCGSSEEDLSGNRKIRA 411

  Fly   493 LTPPSAASGMLSQMAAAS-GMGGGLAG---MRGTTEDSGRGNSLSAFSGSLSGGS---------- 543
            ||..:.:..:.|::..:| |....|..   ::...:.......||:....|..||
Zfish   412 LTHKAYSDIIRSELQMSSRGPSPFLVSPPCLQRDLDSRSLQRMLSSSLEELQSGSLQMHVVERPV 476

  Fly   544 GATAGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDPDSISLVSSQNMYQFGTPK- 607
            .|...:|.:..|:.       .::..|:||..|   .||..:...|..||...|::. ||...|
Zfish   477 EAALENRYNPENNK-------YQTLPGKLNRPD---QNGLRLQCSPLLISPDDSEDS-QFNLRKI 530

  Fly   608 ERS-----PTLSPLNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGS 667
            |::     ..||||:|..  .|.:|  |||.||...|....||.                  ||.
Zfish   531 EKADDSTLSDLSPLSSGV--ESGQQ--SPVSPEHKKNQKGIRKL------------------WGK 573

  Fly   668 ISRVFARSRNKNKALSADGVTEYADYSWNP-----LTEEGYAEKLRLLREASQLPIDRWRATQVL 727
            |      .|.::.:|.||..:::....:..     ||..|.:...|    .:..|..:|...||.
Zfish   574 I------RRTQSGSLPADSDSDFKRGGFRATAGPRLTCLGISTSSR----DTNAPFSKWSCDQVC 628

  Fly   728 AWLEVALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLA-------IEEQRR 785
            .|:| ..|:.||.....:.|.||:.||..:..|:|..||:.||:|||||:||       |.|:.
Zfish   629 TWME-DFGLGQYVNMARQWVTSGQSLLSASSHEIEKELGIKHPLHRKKLQLALHSFSSKITEKS- 691

  Fly   786 PEMVRYPLITQLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQA 850
                     ::|.:.|| |.||.|||||||.:.|.:..||.|||..|:..:| .||.||.:.|..
Zfish   692 ---------SELDYIWV-TRWLDDIGLPQYKDQFNEGRVDGRMLQYLTVNDL-LFLKVTSQLHHL 745

  Fly   851 SIVHGIHVLRIVKYDRQTLAMR-RVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHG 914
            ||...||||.:.|::...|..| ..:::|..::.:.|:|.|.:.|:||:||.|||.||:.|||||
Zfish   746 SIKCAIHVLHVNKFNPNCLKRRPGDENKTSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHG 810

  Fly   915 GLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLT 974
            ||::|||.|:.||:|..|.|||.|.::||||.|.|:.|:........|......|..|||
Zfish   811 GLIILEPRFNSDTLAMLLNIPPQKTLLRRHLATNFNTLVGSQAQQEKQEFLESSGYTPLT 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	27/103 (26%)
		SAM_kazrin_repeat1	718..787	CDD:188963	28/75 (37%)
		SAM	719..781	CDD:197735	26/68 (38%)
		SAM_kazrin_repeat2	796..860	CDD:188966	31/63 (49%)
		SAM	805..860	CDD:197735	27/54 (50%)
		SAM_kazrin_repeat3	882..953	CDD:188969	38/70 (54%)
		SAM	885..>934	CDD:197735	28/48 (58%)
ppfibp2b	NP_001313527.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920