DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Ppfia2

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_030100997.1	Gene:	Ppfia2 / 327814	MGIID:	2443834	Length:	1264	Species:	Mus musculus

Alignment Length:	1243	Identity:	288/1243 - (23%)
Similarity:	460/1243 - (37%)	Gaps:	363/1243 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 STSSGATGSGGGGAP--AKPSPLVLASKRDLTPSNESSSSPSSSNGSNQTLTPPM----TADNQP 136
            |.:.|.|||.|...|  |..:..:.|.:..|....|..|...:...:.:.|...:    :...:.
Mouse    87 SLTGGLTGSKGADPPEFAALTKELNACREQLLEKEEEISELKAERNNTRLLLEHLECLVSRHERS 151

  Fly   137 LQQQLQHHQHRSPAYPGKPAEAAGGVPQQQQQQQQLPN------GIGSSHCNSNSNGISSTCNSG 195
            |:..:...|.:||:......|....:....:..:.|..      .:.....::....:::.....
Mouse   152 LRMTVVKRQAQSPSGVSSEVEVLKALKSLFEHHKALDEKVRERLRVSLERVSALEEELAAANQEI 216

  Fly   196 TAM----IHANNSNLIAAG-----HL--AQAAGPAHNAPSSGSALNAVD-------------KRN 236
            .|:    :|.....:.:.|     ||  .:|....|....|..::::.|             |:|
Mouse   217 VALREQNVHIQRKMVSSEGSTESEHLEGMEAGQKVHEKRLSNGSIDSTDDTSQIVELQELLEKQN 281

  Fly   237 ANLSEPDQDLPPNLNVNLSPNPSLALGAPHSPTSAASAALLLLESCDGNRNDESRFHHLHSAPRP 301
            ..:::..:.|..         .|..:|........|...|:..|..:.....:.|..:|.:..:.
Mouse   282 YEMAQMKERLTA---------LSSRVGEVEQEAETARKDLIKTEEMNTKYQRDIRECYLQAMAQK 337

  Fly   302 E------ATMKLR------------EENDRLNAELL--------------RLRRLLELS---TDG 331
            |      .|::.|            :.||:|..||.              :|:..|||:   ...
Mouse   338 EDMEERITTLEKRYLSAQRESTSIHDMNDKLENELANKEAILRQMEEKNRQLQERLELAEQKLQQ 402

  Fly   332 AVGGVDTAPEMEAVASGEGSA----------AKERIERLESELRSVKNQLLTMRLERKKLRTDKS 386
            .:...:|.||:||..:...:|          .:||:..||.:|.. |||.|....:|:|:..:.:
Mouse   403 TMRKAETLPEVEAELAQRIAALTKAEERHGNIEERMRHLEGQLEE-KNQELQRARQREKMNEEHN 466

  Fly   387 DLLG----------------QVKQLCASLQEKE---QELRDFIRNYQERVRETETTNAKISGDRD 432
            ..|.                .:|:..|:|:||.   ||..:|.:|.:|.:.:.|....:|  ::.
Mouse   467 KRLSDTVDRLLTESNERLQLHLKERMAALEEKNVLIQESENFRKNLEESLHDKERLAEEI--EKL 529

  Fly   433 RERFQLLKQ----------ARDEAERSLALAQQL-SARDLQLQ-RLQEQLQEARR---------- 475
            |.....:|.          :|...:.|..|...: |..|.|.. |..:.::..||
Mouse   530 RSELDQMKMRTGSLIEPTISRTHIDTSTELRYSVGSLVDSQSDYRTTKVIRRPRRGRMGVRRDEP 594

  Fly   476 -------------QLTGCL----------------SDQESLHSFAPLTPPSAASG------ML-- 503
                         |..|.|                .|:|::.|...|..||..|.      ||
Mouse   595 KVKSLGDHEWNRTQQIGVLGSHPFESDTEMSDIDDDDRETIFSSMDLLSPSGHSDAQTLAMMLQE 659

  Fly   504 ---------------------------SQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSG 541
                                       :::|:.|..|..||.:.       .|.|::|   |::.
Mouse   660 QLDAINKEIRLIQEEKESTELRAEEIENRVASVSLEGLNLARVH-------PGTSITA---SVTA 714

  Fly   542 GSGATAGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDPD------SISLVSSQNM 600
            .|.|::...:..|.......|..||            .|....:|:..|      .|::|.....
Mouse   715 SSLASSSPPSGHSTPKLTPRSPARE------------MDRMGVMTLPSDLRKHRRKIAVVEEDGR 767

  Fly   601 YQFGTPK-ERSPTLSP--------LNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLG 656
            ....|.| |.||..:|        |.|:.::.:...|.:.::|:..|.|:     ||:|:.. |.
Mouse   768 EDKATIKCETSPPPTPRAVRMTHTLPSSYHNDARSSLSASLEPDSLGLGS-----ANSSQDS-LH 826

  Fly   657 ARNGRGGTWGSISRVFARSRNKNKA----LSADGVTEYADYSWNPLTEEG-YAEKLR-------- 708
            ....:.|...||.|:|.:   |.||    |.....||.|......|.:.| .|||.|
Mouse   827 KAPKKKGIKSSIGRLFGK---KEKARLGQLRGFMETEAAAQESLGLGKLGTQAEKDRRLKKNTSG 888

  Fly   709 --LLREASQ--LPIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLA 768
              ||.||.:  ||..:|....|:||||:.||||. |.|.|..|||||.::..|:|.|::..:|::
Mouse   889 HELLEEARRKGLPFAQWDGPTVVAWLELWLGMPAWYVAACRANVKSGAIMSALSDTEIQREIGIS 953

  Fly   769 HPMHRKKLRLAIEE------------QRRP---------EM-----------------VRYPLIT 795
            :|:||.||||||:|            .|.|         ||                 .:.|:..
Mouse   954 NPLHRLKLRLAIQEMVSLTSPSAPPTSRTPSGNVWVTHEEMENLTAPAKTKESEEGSWAQCPVFL 1018

  Fly   796 Q------LGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVH 854
            |      :.|.|:..||||.:|||||...|::.||||||||.|:||:|...|.:...||:.|:.:
Mouse  1019 QTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQY 1083

  Fly   855 GIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVL 919
            ||..|:.:.|||:.|..||..|:....|.:||:|.|.|||:::|.|.|||:|:.:|||||.|:.|
Mouse  1084 GIMCLKRLNYDRKELERRREASQHEIKDVLVWSNDRVIRWIQAIGLREYANNILESGVHGSLIAL 1148

  Fly   920 EPSFSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPGGLQHYAT 984
            :.:|...::|..|.||......|:.|..|::.|:     .||
Mouse  1149 DENFDYSSLALLLQIPTQNTQARQILEREYNNLL-----ALG----------------------- 1185

  Fly   985 TDRR----SSGNLR----------------ISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNSTS 1029
            |:||    ...|.|                ||...||..:|...||..         ::.|.|..
Mouse  1186 TERRLDESDDKNFRRGSTWRRQFPPREVHGISMMPGSSETLPAGFRLT---------TTSGQSRK 1241

  Fly  1030 PTPSYSSS 1037
            .|...:||
Mouse  1242 MTTDVASS 1249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	29/124 (23%)
		SAM_kazrin_repeat1	718..787	CDD:188963	34/90 (38%)
		SAM	719..781	CDD:197735	30/62 (48%)
		SAM_kazrin_repeat2	796..860	CDD:188966	31/69 (45%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	29/70 (41%)
		SAM	885..>934	CDD:197735	23/48 (48%)
Ppfia2	XP_030100997.1	Smc	<39..330	CDD:224117	37/251 (15%)
		Smc	<201..540	CDD:224117	63/350 (18%)
		SAM_liprin-alpha1,2,3,4_repeat1	902..972	CDD:188961	32/69 (46%)
		SAM_liprin-alpha1,2,3,4_repeat2	1026..1091	CDD:188964	31/64 (48%)
		SAM_liprin-alpha1,2,3,4_repeat3	1111..1182	CDD:188967	29/70 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810