DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Kazn

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_017448912.1	Gene:	Kazn / 313672	RGDID:	1359147	Length:	868	Species:	Rattus norvegicus

Alignment Length:	810	Identity:	276/810 - (34%)
Similarity:	406/810 - (50%)	Gaps:	147/810 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   265 PHSPTSAASAALLLLESCDGNRNDESRFHHLHSAPRPEATMKLREENDRLNAELLRLRRLLELST 329
            |.:.|||::||:.:.:|......     :|.|.     |.:.||||..:|..|:..||::.|:
  Rat   139 PGAATSASAAAVTVADSAVATME-----NHQHG-----AQVLLREEVVQLQEEVHLLRQMKEM-- 191

  Fly   330 DGAVGGVDTAPEMEAVASGEG----SAAKERIE--RLESELRSVKNQLLTMRLERKKLRTDKSDL 388
                    .|.::|....|:.    ||.:.|::  :.|.||...:..|..|:.:||:|:.:|:||
  Rat   192 --------LAKDLEESQGGKCSEVLSATELRVQLVQKEQELARAREALQAMKADRKRLKGEKTDL 248

  Fly   389 LGQVKQLCASLQEKEQELRDFIRNYQERVRETETTNAKISGDRD---RERFQLLKQARDEAERSL 450
            :.|::||.|:|:.:|::||||||||::..:|:|.....::.::|   ||:::|.:||::..:.:.
  Rat   249 VSQMQQLYATLESREEQLRDFIRNYEQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHAA 313

  Fly   451 ALAQQLSARDLQLQRLQEQLQEARRQLTGCLSDQESLHSFAPLTPPSAASGMLSQMAAASGMGGG 515
            ||..||..:|.:::.|:.:|..|::.|.....|....||.|
  Rat   314 ALRSQLDLKDNRMKELEAELAMAKQSLATLTKDVPKRHSLA------------------------ 354

  Fly   516 LAGMRGTTEDSGRGNSLSAFSGSLSGGSGATAGDRNSCSN--DSGLRNSSDRESTGGELNFSDGT 578
               |.|.|..:  ||........|.    .||..|.|...  .|...:.:||::.
  Rat   355 ---MPGETVLN--GNQEWVVQADLP----LTAAIRQSQQTLYHSHPPHPADRQAV---------- 400

  Fly   579 CDNGPCITVDPDSISLVS------SQNMYQFGTPKERSPTL------SPLNSAAYSRSVEQLGSP 631
             ...||.:..|..||..|      |.......:|:.|:.:|      .|:..:.::..|:.|...
  Rat   401 -RVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKSLHNPIVQSLEDL 464

  Fly   632 VDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGSISRVFARSRNKNKALSADGVTEYADYSWN 696
            .|.:        ||    .|...:|        :|||||||||.:.: |:|. .|:.:.:|...:
  Rat   465 EDQK--------RK----KKKEKMG--------FGSISRVFARGKQR-KSLD-PGLFDDSDSQCS 507

  Fly   697 P------LTE-EGYAEKLRLLREASQLPIDRWRATQVLAWLEVALGMPQYSARCAENVKSGKVLL 754
            |      |:| |...::|:.:......|:..|:|..|.|||||.:.||.|...||||||||||||
  Rat   508 PTRHSLSLSEGEEQMDRLQHVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACAENVKSGKVLL 572

  Fly   755 ELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVR-YPLITQLGHTWVATEWLPDIGLPQYAEP 818
            .|:|.:||.|||:...:||:|||||||:.|..|..| ......|.|.|||..||.||||.||::.
  Rat   573 SLSDEDLELGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAADLDHHWVAKAWLNDIGLSQYSQA 637

  Fly   819 FVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDP 883
            |...|||.|||::|.|::|||.|.|::||||.||:.||.:|..|.:.|:.|..||.:.||.:|||
  Rat   638 FQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRARCETQNTDP 702

  Fly   884 IVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTE 948
            :||||||.::|||.|||.||||||.:|||||.::||||:|:.:.||||||||..|:|:||||..|
  Rat   703 VVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGIPSGKHILRRHLAEE 767

  Fly   949 FDALILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRRSSGNLRISAWKGSQSSLSKAFRFNS 1013
            ...:..||.:|   |||..            :.:.|...|:|...|.....||.         ||
  Rat   768 MSTVFHPANST---GIRES------------ERFGTPPGRASSITRAGKEDGSS---------NS 808

  Fly  1014 KPHRTGDRSSFG----NSTSPTPSYSSSEG 1039
            | :||| |...|    ..:|..|.|....|
  Rat   809 K-YRTG-RLPLGKIGRGFSSKEPDYYDDYG 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	35/104 (34%)
		SAM_kazrin_repeat1	718..787	CDD:188963	40/68 (59%)
		SAM	719..781	CDD:197735	37/61 (61%)
		SAM_kazrin_repeat2	796..860	CDD:188966	35/63 (56%)
		SAM	805..860	CDD:197735	30/54 (56%)
		SAM_kazrin_repeat3	882..953	CDD:188969	45/70 (64%)
		SAM	885..>934	CDD:197735	33/48 (69%)
Kazn	XP_017448912.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341765
Domainoid	1	1.000	83	1.000	Domainoid score	I8181
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H16235
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2279
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	1	1.000	-	-		FOG0006459
OrthoInspector	1	1.000	-	-		oto97060
orthoMCL	1	0.900	-	-		OOG6_106939
Panther	1	1.100	-	-	LDO	PTHR12776
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4710
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.800