DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Ppfibp1

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_008761604.1	Gene:	Ppfibp1 / 312855	RGDID:	1310010	Length:	1032	Species:	Rattus norvegicus

Alignment Length:	911	Identity:	221/911 - (24%)
Similarity:	331/911 - (36%)	Gaps:	272/911 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 APHSPTSAASAALLLLESCDG----NRNDESRFHHLHSAPRPEATMKLREE---NDRLNAEL--- 318
            :|.||...:..||.|:|...|    ...||........   |::|.::..|   |...|..|
  Rat    37 SPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQI---PDSTAEMLIEWLQNQMTNGHLPGN 98

  Fly   319 --LRLRRLLELSTDGAVGGVDTAPEMEAVASGEGSAAKERIERLE-------SELRSVKNQLLTM 374
              :...||..|..|     .::.....:|.:.:..|..|:|..||       .:|.:.:..|...
  Rat    99 GDVYQERLARLEND-----KESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKLNATEEMLQQE 158

  Fly   375 RLERKKLRTDKSDLLGQVKQLCASLQEKEQELRDFIRNYQERVRETETTNAKIS------GDRDR 433
            .|.|..|.|.|.:|:.::..|...|...|::..|    |::|.|:||....:|:      .:.|.
  Rat   159 LLSRTSLETQKLELMAEISNLKLKLTAVEKDRLD----YEDRFRDTEGLIQEINDLRLKVNEMDS 219

  Fly   434 ERFQLLK--------------------QARDEAERS-----------LALAQQLSARDLQLQRLQ 467
            ||.|..|                    |.:.|.:|.           .:|.:||..::.:::|||
  Rat   220 ERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWETLKDELASLKEQLEEKECEVKRLQ 284

  Fly   468 EQL-------------------------------------------QEARRQ---LTGCLSDQES 486
            |:|                                           :|..|:   |..|||....
  Rat   285 ERLVCKTKGEGVEILDRDENIKRKLKEKNIEVQKMKKAVESLMAANEEKERKIEDLRQCLSRYRK 349

  Fly   487 LHSFAPLTPPSAA-------SGMLSQMAAASGMG------GGLAGMRGTTEDSGRGNSLSAFSGS 538
            :...|.|......       |..:|.:..|.|..      ....||...:.|....::...|..|
  Rat   350 VQDPAALAQGQEGECEGLFHSSSISTLLDAQGFSDLERSTSSTPGMGSPSRDPLHTSAPEEFHTS 414

  Fly   539 LSGGS----GATAGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVD-----PDSISL 594
            :...|    ..|:.|..:|        ...:.:|..|.:|.:|  |....:..|     .|.:|.
  Rat   415 VLQASVPSLFPTSMDEETC--------EKPKLATKPETSFEEG--DGRAVLGADAEVSLSDGVST 469

  Fly   595 VSSQNMYQFGT-----------------PKERSPTLSPLNSAAYSRSVEQLGSPVDPEGPGNGAI 642
            .|.|.....|.                 |::::||.|           ...|: :.|:.||:||
  Rat   470 SSLQKSSSLGNLKKETSDGVEKESIQKPPEDKTPTDS-----------HTFGT-LPPKAPGHGA- 521

  Fly   643 SRKFANASKSGPLGARNGRGGTWGSISRVF---------ARSRNKNKALSADGVT---------E 689
                  :....|.|.|..|    .|..|.|         |.:.|.::..||...|         |
  Rat   522 ------SVDDSPFGTRKAR----SSFGRGFFKIKSGKRTASAPNLDRKRSASAPTLAETEKETDE 576

  Fly   690 YADY--------------------------------------------SWNP--LTEE------- 701
            :.|.                                            ::||  ::|.
  Rat   577 HLDLAGTSRPKGSQGTSPFQMSPPSPDSRKKSRGIMRLFGKLRRSQSTTFNPDDMSEPEFKRGGT 641

  Fly   702 --------GYAEKLRLLREASQLPIDRWRATQVLAWLEVALGMPQYSARCAENVKSGKVLLELND 758
                    |::..|.........|..:|...||.:|| ...|:..|.:.....:.||:.||:.:.
  Rat   642 RATAGPRLGWSRDLGQSNSDLDTPFAKWTKEQVCSWL-AEQGLGSYLSSGKHWIMSGQTLLQASQ 705

  Fly   759 VELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPLITQLGHTWVATEWLPDIGLPQYAEPFVQSL 823
            .:||..||:.|.:|||||:||::.....|...|   .:|...|| |.||.|||||||...|.:..
  Rat   706 QDLEKELGIKHSLHRKKLQLALQALGSEEETNY---GKLDFNWV-TRWLDDIGLPQYKTQFDEGR 766

  Fly   824 VDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPI-VWT 887
            ||.|||..::..:|.. |.|....|..||...|.||||..::...|..|.....::....: .||
  Rat   767 VDGRMLHYMTVDDLLS-LKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENSITPSEVQQWT 830

  Fly   888 NQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDAL 952
            |.|.:.|:||:||.|||.||:.|||||||:||||.|:.:|||..|.|||:|.::||||.|.|:.|
  Rat   831 NHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLL 895

  Fly   953 I 953
            |
  Rat   896 I 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	27/108 (25%)
		SAM_kazrin_repeat1	718..787	CDD:188963	23/68 (34%)
		SAM	719..781	CDD:197735	23/61 (38%)
		SAM_kazrin_repeat2	796..860	CDD:188966	27/63 (43%)
		SAM	805..860	CDD:197735	23/54 (43%)
		SAM_kazrin_repeat3	882..953	CDD:188969	40/71 (56%)
		SAM	885..>934	CDD:197735	30/48 (63%)
Ppfibp1	XP_008761604.1	Smc	<100..>352	CDD:224117	50/260 (19%)
		PHA03307	383..>648	CDD:223039	47/297 (16%)
		SAM_liprin-beta1,2_repeat1	666..729	CDD:188962	23/63 (37%)
		SAM_liprin-beta1,2_repeat2	740..802	CDD:188965	27/63 (43%)
		SAM_liprin-beta1,2_repeat3	825..896	CDD:188968	40/70 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920