DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Ppfia1

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_038964049.1	Gene:	Ppfia1 / 293645	RGDID:	1309009	Length:	1267	Species:	Rattus norvegicus

Alignment Length:	1292	Identity:	303/1292 - (23%)
Similarity:	473/1292 - (36%)	Gaps:	436/1292 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LHKLGESKIAKSLDTSVSTGLKEKAASVNNNKPI--RPLLSLDSSVTASTSSGATGSGGGGAPAK 94
            ||::|..:  .||...::|.|.::.|::.....:  ..||..:..:....           |...
  Rat    68 LHEVGHER--DSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELK-----------AERN 119

  Fly    95 PSPLVLASKRDLTPSNESS----------SSPSSSNGSNQTLTPPMTADNQPLQQQLQHHQHRSP 149
            .:.|:|.....|...:|.|          .||:..:...:.|        :.|:...:||:
  Rat   120 NTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVL--------KALKSLFEHHK---- 172

  Fly   150 AYPGKPAEAAGGVPQQQQQQQQLPNGIGSSH--------CNSNSNGISSTCNSGTAMIHANNSNL 206
            |...|..|.   :....::...|...:|::|        .||....::.      .|:..|:..
  Rat   173 ALDEKVRER---LRVALERCSLLEEELGATHKELMILKEQNSQKKALTE------GMLDGNHEQ- 227

  Fly   207 IAAGHLAQAAGPAHNAPSSGSALNAVDKRNANLSEPDQDLPPNLNV----------NLSPNPSLA 261
                         .||||:..      ||:::.|...:||...|.:          .......||
  Rat   228 -------------ENAPSTNG------KRSSDGSLSHEDLAKVLELQEVIDRQAREQSQMKERLA 273

  Fly   262 LGAPHSPTSAASAALLLLESCDGNRND-------------------------ESRFHHL---HSA 298
                    |.:|.|..|.|..|..|.|                         |.|...|   :.|
  Rat   274 --------SLSSHAAELEEDLDTARKDLIKSEEMNTKLQREVREAMAQKEDMEERITTLEKRYLA 330

  Fly   299 PRPEATMKLREENDRLNAELL--------------RLRRLLELS---TDGAVGGVDTAPEMEA-- 344
            .:.||| .:.:.||:|..|:.              :|:..|||:   ....:...:|.||:||
  Rat   331 AQREAT-SVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAEL 394

  Fly   345 ------------VASGEGSAAK----------------------ERIERLESELRSVKNQLLTMR 375
                        ::|| .||||                      ||:.::|::|.. |||.|...
  Rat   395 AQRVAALSKSGPLSSG-SSAAKEAKLLELTSKLRKAEERHGNIEERLRQMEAQLEE-KNQELQRA 457

  Fly   376 LERKKLRTDKSDLLG----------------QVKQLCASLQEKEQELRDFIRNYQERVRET---- 420
            .:|:|:..:.:..|.                .:|:..|:|::|...||: :.|.::::.||
  Rat   458 RQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLRE-VENAKKQLEETQHDK 521

  Fly   421 -------ETTNAKISGDRDRE----------------RFQLLKQARDEAERSLALAQ----QLSA 458
                   |...|::...|.|.                ||.:.....|....|..|.:    :|:|
  Rat   522 DQLVLNIEALKAELEQMRLRGSSLHHGRPHLGSVPDFRFSVADGHVDAYSTSAVLRRPQKGRLAA 586

  Fly   459 -RD--LQLQRLQEQLQEARRQLTGCLS-----------------DQESLHSFAPLTPPSAASG-- 501
             ||  .::|.|.||..| |.|....|:                 |:::|.|...|..||..:.
  Rat   587 LRDEPSKVQTLNEQDWE-RAQQASVLANVAQAFESDVDVSDGEDDRDTLLSSVDLLSPSGQADAQ 650

  Fly   502 ----MLSQMAAA-----------------------SGMGGGLAGMRGTTEDSGRGNSLSAF---- 535
                ||.:...|                       |.:|.      |:.::.||..|:|:.
  Rat   651 TLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGS------GSLDNLGRFRSMSSIPPYP 709

  Fly   536 SGSLSG----GSGATAGDR--NSCSND----------SGLRNSSDRESTGGELNFSDGT---CDN 581
            :.||:|    |||.:...|  :|.:.:          |.||....:.....|....|.|   |:.
  Rat   710 ASSLAGSSPPGSGRSTPRRVPHSPAREVDRLGVMTLPSDLRKHRRQLPASREEVRDDKTTIKCET 774

  Fly   582 GPCITVDP--------DSISLVSSQNMYQF--GTPKERSPTLSPLNSAAYSRSVEQLGSPVDPEG 636
            .|..:..|        .::..||.:::...  .|..:..|..:|.:|.:...|:.:.     |:.
  Rat   775 SPPSSPRPLRLDRLHKGALHTVSHEDIRDLRNSTGSQDGPVSNPSSSNSSQDSLHKA-----PKK 834

  Fly   637 PG-NGAISRKFANASKS--GPLGARN-GRGGTWGSISRVFARSRNKNKALSADGVTEYADYSWNP 697
            .| ..:|.|.|....|.  ||||..: |:.|.          |..:|.:..|.|:::..
  Rat   835 KGIKSSIGRLFGKKEKGRPGPLGKESPGQAGV----------SETENSSQDALGLSKLG------ 883

  Fly   698 LTEEGYAEKLR-------LLREASQ--LPIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKV 752
                |.|||.|       ||.||.:  ||..:|....|:.|||:.:|||. |.|.|..|||||.:
  Rat   884 ----GQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAI 944

  Fly   753 LLELNDVELEAGLGLAHPMHRKKLRLAIEE----------------------------------Q 783
            :..|:|.|::..:|:::|:||.||||||:|                                  |
  Rat   945 MSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTTGNVWLTHEEMETLTATPQ 1009

  Fly   784 RRPEMVRYPLIT----QLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVT 844
            ...|...:...|    .:.|.|:..||||.:|||||...|::.||||||||.|:||:|...|.:.
  Rat  1010 TEDEEGSWAQQTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMV 1074

  Fly   845 RKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKD 909
            ..||:.|...||..||.:.|||:.|..:|.:|:....|.:||:|.|.|||:.||.|.|:|:||.:
  Rat  1075 DSFHRNSFQCGIMCLRRLNYDRKELERKREESQNETRDVLVWSNDRVIRWILSIGLKEFANNLIE 1139

  Fly   910 SGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLT 974
            |||||.|:.|:.:|....:|..|.||......|..|..||:.|:                   :|
  Rat  1140 SGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLL-------------------VT 1185

  Fly   975 GPGGLQHYATTDRR-----SSGNLRISAWK-------------GSQSSLSKAFRFNS 1013
            |         ||||     .....|..:|:             ||..:|...||..|
  Rat  1186 G---------TDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLASGSAETLPANFRVTS 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	34/174 (20%)
		SAM_kazrin_repeat1	718..787	CDD:188963	31/103 (30%)
		SAM	719..781	CDD:197735	28/62 (45%)
		SAM_kazrin_repeat2	796..860	CDD:188966	30/63 (48%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	31/70 (44%)
		SAM	885..>934	CDD:197735	24/48 (50%)
Ppfia1	XP_038964049.1	Smc	45..>418	CDD:224117	78/413 (19%)
		SMC_prok_B	246..>545	CDD:274008	63/310 (20%)
		SMC_prok_A	421..>685	CDD:274009	50/266 (19%)
		SAM_liprin-alpha1,2,3,4_repeat1	909..979	CDD:188961	30/69 (43%)
		SAM_liprin-alpha1,2,3,4_repeat2	1027..1092	CDD:188964	32/64 (50%)
		SAM_liprin-alpha1,2,3,4_repeat3	1112..1183	CDD:188967	31/70 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0249
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810