DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Ppfibp2

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	XP_030098095.1	Gene:	Ppfibp2 / 19024	MGIID:	894649	Length:	951	Species:	Mus musculus

Alignment Length:	1043	Identity:	263/1043 - (25%)
Similarity:	386/1043 - (37%)	Gaps:	309/1043 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 PGKPAEAA-GGVPQQQQQQQQLPNGIGSSHCNSNSNGISSTCNSGTAMIHANNSNLIAAGHLAQA 215
            |..|.|.. .|:  |||:.:|:...:.|.                             |.|:.:|
Mouse    14 PEPPREKLHSGI--QQQETKQIKGAMTSD-----------------------------ASHMLEA 47

  Fly   216 AGPAHNAPSSGSALNAVDKRNANLS----EPDQDLPPNLNVNLSP------NPSLALGAPHSPTS 270
            |....:...:|:      |..|:.|    ||... ||:..:|..|      :..|||
Mouse    48 ALEQMDGIIAGT------KTAADFSDGTCEPGLS-PPSTCLNSMPVLHLIEDLRLAL-------- 97

  Fly   271 AASAALLLLESCDGNRNDESRFHHLHSAPRPEATMKLRE---------------ENDRLNAELLR 320
                .:|.|        .:.|...|...|.|.||. ::|               .|:.....|.|
Mouse    98 ----EMLAL--------PQEREALLSQVPGPTATY-IKEWFEDSLSQVNHHGAASNETYQERLAR 149

  Fly   321 LR-----RLLELS--TDGAVGGVDTAPEMEAVASGEGSAAKERIERLESELRSVKNQLLTMRLER 378
            |.     .:|::|  ||......:...::|....|.........|.|:.||           |.|
Mouse   150 LEGDKESLILQVSVLTDQVEAQGEKIRDLEVCLEGHQVKLNAAEEMLQQEL-----------LSR 203

  Fly   379 KKLRTDKSDLLGQVKQLCASL-----QEKEQELRDFIRNYQERVRETETTNAKISGDRDRERFQL 438
            ..|.|.|.||:.:|.:|...|     ::||||.:.  |..:|.::|.:....|:. :.:.||.|.
Mouse   204 TSLETQKLDLMTEVSELKLKLVGMEKEQKEQEEKQ--RKAEELLQELKHLKIKVE-ELENERNQY 265

  Fly   439 ---LKQARDEAERSLALAQQLSARDLQLQRLQEQL--------------QEARRQLTG----CLS 482
               ||..:.|..:   |.:|::.:|.:::||..||              ||..|...|    .::
Mouse   266 EWELKATKAEVAQ---LQEQVALKDAEIERLHSQLSRSAALHSDHAERDQEIHRLKMGMETLLVA 327

  Fly   483 DQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGG----- 542
            :::.......||      |:|::......:   :...:|.:|     .:||.....:.|.
Mouse   328 NEDKDRRIEELT------GLLNKYLRVKEI---VMATQGPSE-----RTLSINEDEIEGSFRKWN 378

  Fly   543 ------------------SGATAG--------------DRNSCSNDSGLRNSSDRESTGGELN-- 573
                              |..|.|              .:.|||.:...|.|.|:...|.:|:
Mouse   379 TTNKSPEEVPKQEISPRCSSPTPGPPPLPQKSLESRAQKKLSCSLEDLRRESGDKCVDGNQLSPV 443

  Fly   574 -------------------FSDGTCDNG------PCITVDPDSISLVSSQNMYQFGTPKERSPTL 613
                               ...|...||      |..::.|||..  |||.....|. ...:|.|
Mouse   444 GEPKDSSFLAEQKYPTLPGKLSGATPNGEAAKSPPTASLQPDSSG--SSQPKLNRGW-SVSAPVL 505

  Fly   614 -------SPLNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARNGRGGTWGSISRV 671
                   ..:.|:|.|.:.....|||.|:|              |..|.|.:.    .||.|.|
Mouse   506 GDTEGGWEDIVSSASSGTESSPQSPVTPDG--------------KRSPKGIKK----FWGKIRR- 551

  Fly   672 FARSRNKNKALSADGVTEYADYSWNPLTEEGYAEKLRLLREA------SQLPIDRWRATQVLAWL 730
             .:|.|.|  ..|.|:.|:.........    ..:|...|:.      :..|..:|...:|..|:
Mouse   552 -TQSGNFN--TDAPGMAEFRRGGLRATA----GPRLSRTRDTKGQKCDANAPFAQWSTERVCTWM 609

  Fly   731 EVALGMPQYSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPLIT 795
            | ..|:.||.....:.|.||..||.....::|..||:.||:|||||.||::.....:.....|
Mouse   610 E-DFGLGQYVIFARQWVTSGHTLLTATPQDMEKELGIKHPLHRKKLVLAVKAINAKQEETSAL-- 671

  Fly   796 QLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLR 860
             |.|.|| |.||.|||||||.:.|.:|.||.|||..|:..:| .||.||.:.|..||...||||.
Mouse   672 -LDHIWV-TRWLDDIGLPQYKDQFHESRVDGRMLQYLTVNDL-LFLKVTSQLHHLSIKCAIHVLH 733

  Fly   861 IVKYDRQTLAMRRVQSETVDTDPIV-WTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFS 924
            :.|::...|..|......:....:| |:|.|.:.|:||:||.|||.||:.|||||||::|||.|:
Mouse   734 VNKFNPNCLHRRPADESNLSPSEVVQWSNHRVMEWLRSVDLAEYAPNLRGSGVHGGLIILEPRFT 798

  Fly   925 GDTMATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPG-------GLQHY 982
            |||:|..|.|||.|.::||||.|:|:|||.|......:...:.....|||...       |..|:
Mouse   799 GDTLAMLLNIPPQKTLLRRHLTTKFNALIGPEAEQEKRDKMASPAYTPLTTTAKVRPRKLGFSHF 863

  Fly   983 ATTDRRSSGNLRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNST------SPTPSYSSSEGGG 1041
                    ||:|                          :..|..||      .|..:.|.|....
Mouse   864 --------GNMR--------------------------KKKFDESTDYICPMEPGDAVSDSHRVY 894

  Fly  1042 GIY 1044
            |:|
Mouse   895 GVY 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	26/100 (26%)
		SAM_kazrin_repeat1	718..787	CDD:188963	24/68 (35%)
		SAM	719..781	CDD:197735	24/61 (39%)
		SAM_kazrin_repeat2	796..860	CDD:188966	33/63 (52%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	41/71 (58%)
		SAM	885..>934	CDD:197735	30/49 (61%)
Ppfibp2	XP_030098095.1	SMC_prok_B	<141..>344	CDD:274008	52/225 (23%)
		SAM_liprin-beta1,2_repeat1	597..660	CDD:188962	24/63 (38%)
		SAM_liprin-beta1,2_repeat2	671..733	CDD:188965	34/66 (52%)
		SAM_liprin-beta1,2_repeat3	756..827	CDD:188968	41/70 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7116
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.880