Protein Alignment Liprin-gamma and hlb-1

DIOPT Version :9

• Sequence 1: NP_001097414.1
• Gene: Liprin-gamma / 37552
• FlyBaseID: FBgn0034720
• Length: 1152
• Species: Drosophila melanogaster
• Sequence 2: NP_001309708.1
• Gene: hlb-1 / 181499
• WormBaseID: WBGene00011904
• Length: 1004
• Species: Caenorhabditis elegans
• Alignment Length: 1087
• Identity: 246/1087 - (22%)
• Similarity: 399/1087 - (36%)
• Gaps: 274/1087 - (25%)

  Fly    78 STSSGATGSGGGGAPAKPSPLVLASKRDLTPSNESSSSPSSSNGSNQTLTPPMTADNQPLQQQLQ 142
            |||...|..|..|    |:|::..|.|||.|...:..|..|          |...:|.  ...|.
 Worm    53 STSRSTTTIGSAG----PTPIIKKSFRDLLPPPPALRSTFS----------PRIMENG--HSNLA 101

  Fly   143 HHQHRSPAYPGKPAEAAGGVPQQQQQQQQLPNGIGSSHCNS---NSNGISSTCNSGTAMIHANNS 204
            |.||.:                     ..:.||......:|   |...||:.....|.:....:|
 Worm   102 HKQHIN---------------------DDIDNGNADDERSSREINRQWISTDWKHRTDLGSDGSS 145

  Fly   205 NLIAAGHLAQAAGPAHNAPSSGSAL-----------NAVDKRNANLSEPDQDLPPNLNV------ 252
            .:         ..|..:.|:|.|:|           .|:|::... ..|  ||...|.:
 Worm   146 GV---------ESPPSDLPTSSSSLFSPPRVYQEFVKAIDEQTMT-ERP--DLETRLKIMQWVAG 198

  Fly   253 NLSPNPSLA-LGAPHSPTSAASAALLLLESCDGNRNDESRFHHLHSAPRPEATMKLREENDRLNA 316
            ..||:||:: :..|..|                                        |..|:|:
 Worm   199 RTSPSPSMSTVSCPEYP----------------------------------------ELQDKLH- 222

  Fly   317 ELLRLRRLLELSTDGAVGGVDTAPEMEAVASGEGSAAKERIERLESELRSVKNQLLTM------- 374
            .|...|..|:|..              :|.|.:..|.||:|:.||:.:...:|.|.:.
 Worm   223 RLAMARDSLQLQV--------------SVLSEQVGAQKEKIKDLETVIALKRNNLTSTEELLQDK 273

  Fly   375 --RL-ERKKLRTDKSDLLGQVKQL---CASLQEKEQELRDFIR---NYQERVRET---------- 420
              |: |.::|.:.|.|||.:|..|   .|:|:.::.|....:|   |..:.|.::
 Worm   274 YHRIDECQELESKKMDLLAEVSSLKLRYATLEREKNETEKKLRLSQNEMDHVNQSMHGMVVQQQL 338

  Fly   421 -ETTNAKISG-----------DRDRERFQLLKQA-----RDEAERSLALAQQLSARDLQL--QRL 466
             ..||...||           :::.:....|:.|     .|...:||.:....:|.|.|:  :..
 Worm   339 AHHTNGHSSGGYMSPLREHRSEKNDDEMSQLRTAVQRLMADNEHKSLQINTLRNALDEQMRSRSQ 403

  Fly   467 QEQLQEARRQLTGCLSDQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGN- 530
            ||....::|..|........:.......|..:.|...|...:.|.......|.|.|.:.|...|
 Worm   404 QEDFYASQRNYTDNFDVNAQIRRILMDEPSDSMSHSTSFPVSLSSTTSNGKGPRSTVQSSSSYNS 468

  Fly   531 SLSAFSGS---LSGGSGA-----TAGDRNSCSN---------------------DSGLRNSSDRE 566
            ||||.|..   .|.|:|.     ..|.....:|                     |...||.::
 Worm   469 SLSAVSPQHNWSSAGAGTPRQLHPIGGNQRVNNITSAQYCSPSPPAARQLAAELDELRRNGNE-- 531

  Fly   567 STGGELNFSDGTCDNG-----PCITVDPDSISLVSSQNMYQFG---------TPKE--RSPTLSP 615
              |...|:|..:...|     ..:|:....:|:.|..::.:.|         |||.  |:.....
 Worm   532 --GANHNYSSASLPRGVGKASSTLTLPSKKLSVASGTSVGELGGSMSSVAQPTPKRNYRAQMNRW 594

  Fly   616 LNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGPLGARN-GRGGTWGSISRVFARSRNKN 679
            :|...  |....:.:|...|.....|..|...||:....|  :| .|..|..|:..:|::   ..
 Worm   595 INEKL--RRKRAVSAPNLVESDDEIARGRNLNNATSQSNL--KNFSRERTRSSLRNIFSK---LT 652

  Fly   680 KALSADGVTEYADYSWNPLTEEGYAEKLRLLREASQLP-----IDRWRATQVLAWLEVALGMPQY 739
            ::.|.|....:...|....|..........|...|:.|     :| ||:.|:..|: ..:|.|||
 Worm   653 RSTSQDQSNSFRRGSAARSTSTARLGSTNHLGTVSKRPPLSQFVD-WRSEQLADWI-AEIGYPQY 715

  Fly   740 SARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLAIEEQRRPEMVRYPLITQLGHTW--- 801
            ....:.:|:||:..|.::..|.|..|.:.:|:|||  |:||..:|..|.:..|     .:.|
 Worm   716 MNEVSRHVRSGRHFLNMSMNEYEGVLNIKNPVHRK--RVAILLRRIEEDIMEP-----ANKWDVH 773

  Fly   802 VATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKYDR 866
            ....||.|||||||.:.|.:::||..:|.:|:..:..: :.|....|.|::...|..|:  |.|.
 Worm   774 QTLRWLDDIGLPQYKDVFAENVVDGPLLLSLTANDAVE-MKVVNAHHYATLARSIQFLK--KADF 835

  Fly   867 QTLAMRR-VQSETVDTDP-----IVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSG 925
            :..||.: :....|:..|     :.||:.....|:|.|||.|:..||..:||.|.|::.||||:.
 Worm   836 RFNAMEKLIDQNIVEKYPCPDVVVRWTHSATCEWLRKIDLAEFTQNLLFAGVPGALMIYEPSFTA 900

  Fly   926 DTMATALGIPPSKNIIRRHLNTEFDALILP-----ARATLGQGIRSGCGVVPLTGPGG-----LQ 980
            :::|..|.:||.|.::||||.:.|:.|:.|     .|..|      ..|..|...|.|     .:
 Worm   901 ESLAEILQMPPHKTLLRRHLTSHFNQLLGPKIIADKRDFL------AAGNYPQISPTGRVKVVKK 959

  Fly   981 HYATTDRRSSGNLRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNS 1027
            .::.|.:::...:.:.    .:..|......:..|...||.|||.:|
 Worm   960 GFSLTRKKAKNEICLE----PEELLCPQVLVHKYPTGAGDNSSFESS 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	29/133 (22%)
		SAM_kazrin_repeat1	718..787	CDD:188963	24/68 (35%)
		SAM	719..781	CDD:197735	22/61 (36%)
		SAM_kazrin_repeat2	796..860	CDD:188966	19/66 (29%)
		SAM	805..860	CDD:197735	18/54 (33%)
		SAM_kazrin_repeat3	882..953	CDD:188969	29/75 (39%)
		SAM	885..>934	CDD:197735	20/48 (42%)
hlb-1	NP_001309708.1	Smc	<216..427	CDD:224117	48/225 (21%)
		SAM_liprin-beta1,2_repeat1	695..758	CDD:188962	23/66 (35%)
		SAM_liprin-beta1,2_repeat2	769..831	CDD:188965	19/62 (31%)
		SAM_liprin-beta1,2_repeat3	857..928	CDD:188968	28/70 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255905at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920