Protein Alignment Liprin-gamma and Ppfia4

DIOPT Version :10

• Sequence 1: NP_001097414.1
• Gene: Liprin-gamma / 37552
• FlyBaseID: FBgn0034720
• Length: 1152
• Species: Drosophila melanogaster
• Sequence 2: XP_063128045.1
• Gene: Ppfia4 / 140592
• RGDID: 620055
• Length: 1188
• Species: Rattus norvegicus
• Alignment Length: 1200
• Identity: 289/1200 - (24%)
• Similarity: 444/1200 - (37%)
• Gaps: 365/1200 - (30%)

  Fly    98 LVLASKRDL--TPSNESSSSPSSSNGSNQTLTPPMTADNQPLQQQLQHHQHRSPAYPGKPAEAAG 160
            ||...:|.|  |.....:.|||..:...:.|        :.|:...:||:    |...|..|...
  Rat   121 LVSRHERSLRMTVVKRQAQSPSGVSSEVEVL--------KALKSLFEHHK----ALDEKVRERLR 173

  Fly   161 GVPQQ-----------QQQQQQLPNGIGSSHCNSNSNGIS---STCNSGTAMIHANNSNLIAAGH 211
            ...::           .||...|..|.|.      .:|::   .|.:.|...:..:::     |.
  Rat   174 AALERVTTLEEQLAGAHQQVSALQQGAGI------RDGVAEEEETVDLGPKRLWKDDT-----GR 227

  Fly   212 LAQAAGPAHNAPSSGSALNAVDKRNANLSEPDQDLPPNLNVNLSPNPSLALGAPHSPTSAASAAL 276
            :.:..|             .::|:|..||:..:.|     |.|    |..:.........|...|
  Rat   228 VEELQG-------------LLEKQNYELSQARERL-----VTL----SATVTELEEDLGTARRDL 270

  Fly   277 LLLESCDGNRNDESR---------------FHHLHSAPRPEATMKLREENDRLNAELL------- 319
            :..|...|....:.|               ....:.|.:.||| .:.:.||:|..||.
  Rat   271 IKSEELSGKHQRDLREALAQKEDMEERITTLEKRYLAAQREAT-SIHDLNDKLENELANKESLHR 334

  Fly   320 -------RLRRLLELS---TDGAVGGVDTAPEMEAVASGEGSA---AKERIERLESELRSV---- 367
                   .|:.|||::   ....:...:|.||:||..|...:|   |:||...:|..||.:
  Rat   335 QCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELSQRIAALTKAEERHGNIEEHLRQLEGQL 399

  Fly   368 --KNQLLTMRLERKKLRTDKSDLLG----------------QVKQLCASLQEKE------QELRD 408
              |||.|....:|:|:..|.:..|.                .:|:..|:|:||.      ::||.
  Rat   400 EEKNQELARVRQREKMNEDHNKRLSDTVDRLLSESNERLQLHLKERMAALEEKGRLSEEIEKLRQ 464

  Fly   409 -----------FIRNYQER--------VRETETTNAKISGDRDRERFQLLKQAR----------- 443
                       |:.....|        ||.:.:|.|.:.....| |:..|::..
  Rat   465 EVDQLKGRGGPFVDGIHSRSHVGSTADVRFSLSTAAHVPPGLHR-RYTALREESAKDWKPAPLPG 528

  Fly   444 -------------------DEAERSLALAQQL---------SARDLQLQRLQEQLQEARRQLTGC 480
                               ||.|....:..|:         .|:.|.:. |||||....:::...
  Rat   529 VLAATTTPAFDSDPEISDVDEDEPGGLVGTQVDVISPGGHSDAQTLAMM-LQEQLDAINQEIRMI 592

  Fly   481 LSDQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGGSGA 545
            ..::||....|........||.:..:....      ...||:...|....||::.|..|||.|..
  Rat   593 QEEKESTELRAEEIETRVTSGSMEALNLTQ------LRKRGSIPTSLTALSLASASPPLSGRSTP 651

  Fly   546 TAGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDPD-------SISLVS-SQNMYQ 602
            ....|::         :.|.:..|              .:|:..|       .:|.|| .:|...
  Rat   652 KLTSRSA---------AQDLDRMG--------------VMTLPSDLRKHRRKLLSPVSREENRED 693

  Fly   603 FGTPK-ERSPTLSPLNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGP------LGARNG 660
            ..|.| |.||..||     .:..:|:||.|...:..|..|:..:.:|.|.|..      .||:
  Rat   694 KATIKCETSPPSSP-----RTLRLEKLGHPTLSQEEGKSALEGQDSNPSSSNSSQDSLHKGAK-- 751

  Fly   661 RGGTWGSISRVFARSRNKNKAL----SADGVTEYADYSWN------PLTEEGYAEKLRLLREASQ 715
            |.|...||.|:|.: :.|.:.:    .|.|.....|...:      |......|||.|.|::..|
  Rat   752 RKGIKSSIGRLFGK-KEKGRLIQLSRDATGHVLLTDSELSLQEPMVPAKLGTQAEKDRRLKKKHQ 815

  Fly   716 L---------PIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHP 770
            |         |..:|....|::|||:.:|||. |.|.|..|||||.::..|:|.|::..:|:::.
  Rat   816 LLEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNA 880

  Fly   771 MHRKKLRLAIEEQ---------------------RRPEMVRYPLITQ----------------LG 798
            :||.||||||:|.                     ...||......|:                :.
  Rat   881 LHRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLATSTKTDSEEGSWAQTLAYGDMN 945

  Fly   799 HTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVK 863
            |.|:..||||.:|||||...|::.||||||||.|:||:|...|.:...||:.|:.:||..|:.:.
  Rat   946 HEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLN 1010

  Fly   864 YDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTM 928
            |||:.|..||.:|:....|.:||||.:.:.||:||.|.:||.||.:|||||.|:.|:.:|..:|:
  Rat  1011 YDRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTL 1075

  Fly   929 ATALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRRSSGN- 992
            |..|.||......|:.:..||:.|:     .||                       |||:....
  Rat  1076 ALVLQIPTQNTQARQVMEREFNNLL-----ALG-----------------------TDRKLDDGE 1112

  Fly   993 ----LRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNSTSPTPSYSSSEGGGGIYATIGHQYPN 1053
                .|..:|:.         ||..:.|.:|  ...|.|....|:       |...:|:|
  Rat  1113 EKVFRRAPSWRK---------RFRPRDHHSG--GMLGTSAETLPA-------GFRVSTLG----- 1154

  Fly  1054 PHTNLQQQHYHHFLPPPTTAPPP--IPSAG 1081
               .||        |||  |||.  :|.||
  Rat  1155 ---PLQ--------PPP--APPKKIMPEAG 1171

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	COG4372	<346..>460	CDD:443500	37/202 (18%)
		SAM_kazrin_repeat1	718..787	CDD:188963	29/90 (32%)
		SAM_kazrin_repeat2	796..860	CDD:188966	30/79 (38%)
		SAM_kazrin_repeat3	882..953	CDD:188969	30/70 (43%)
Ppfia4	XP_063128045.1	None