DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Liprin-gamma and Ppfia4

DIOPT Version :9

Sequence 1:	NP_001097414.1	Gene:	Liprin-gamma / 37552	FlyBaseID:	FBgn0034720	Length:	1152	Species:	Drosophila melanogaster
Sequence 2:	NP_536334.1	Gene:	Ppfia4 / 140592	RGDID:	620055	Length:	1185	Species:	Rattus norvegicus

Alignment Length:	1214	Identity:	291/1214 - (23%)
Similarity:	447/1214 - (36%)	Gaps:	367/1214 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LVLASKRDL--TPSNESSSSPSSSNGSNQTLTPPMTADNQPLQQQLQHHQHRSPAYPGKPAEAAG 160
            ||...:|.|  |.....:.|||..:...:.|        :.|:...:||:    |...|..|...
  Rat   121 LVSRHERSLRMTVVKRQAQSPSGVSSEVEVL--------KALKSLFEHHK----ALDEKVRERLR 173

  Fly   161 GVPQQ-----------QQQQQQLPNGIGSSHCNSNSNGIS---STCNSGTAMIHANNSNLIAAGH 211
            ...::           .||...|..|.|.      .:|::   .|.:.|...:..:::     |.
  Rat   174 AALERVTTLEEQLAGAHQQVSALQQGAGI------RDGVAEEEETVDLGPKRLWKDDT-----GR 227

  Fly   212 LAQAAGPAHNAPSSGSALNAVDKRNANLSEPDQDLPPNLNVNLSPNPSLALGAPHSPTSAASAAL 276
            :.:..|             .::|:|..||:..:.|     |.|    |..:.........|...|
  Rat   228 VEELQG-------------LLEKQNYELSQARERL-----VTL----SATVTELEEDLGTARRDL 270

  Fly   277 LLLESCDGNRNDESR---------------FHHLHSAPRPEATMKLREENDRLNAELL------- 319
            :..|...|....:.|               ....:.|.:.||| .:.:.||:|..||.
  Rat   271 IKSEELSGKHQRDLREALAQKEDMEERITTLEKRYLAAQREAT-SIHDLNDKLENELANKESLHR 334

  Fly   320 -------RLRRLLELS---TDGAVGGVDTAPEMEAVASGEGSA---AKERIERLESELRSV---- 367
                   .|:.|||::   ....:...:|.||:||..|...:|   |:||...:|..||.:
  Rat   335 QCEEKARHLQELLEVAEQKLQQTMRKAETLPEVEAELSQRIAALTKAEERHGNIEEHLRQLEGQL 399

  Fly   368 --KNQLLTMRLERKKLRTDKSDLLG----------------QVKQLCASLQEKE------QELRD 408
              |||.|....:|:|:..|.:..|.                .:|:..|:|:||.      ::||.
  Rat   400 EEKNQELARVRQREKMNEDHNKRLSDTVDRLLSESNERLQLHLKERMAALEEKGRLSEEIEKLRQ 464

  Fly   409 -----------FIRNYQERVRETETTNAKISGDRD-------RERFQLLKQAR------------ 443
                       |:.....|.....||:.:.|....       ..|:..|::..
  Rat   465 EVDQLKGRGGPFVDGIHSRSHVGSTTDVRFSLSTAAHVPPGLHRRYTALREESAKDWKPAPLPGV 529

  Fly   444 ------------------DEAERSLALAQQL---------SARDLQLQRLQEQLQEARRQLTGCL 481
                              ||.|....:..|:         .|:.|.:. |||||....:::....
  Rat   530 LAATTTPAFDSDPEISDVDEDEPGGLVGTQVDVISPGGHSDAQTLAMM-LQEQLDAINQEIRMIQ 593

  Fly   482 SDQESLHSFAPLTPPSAASGMLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGGSGAT 546
            .::||....|........||.:..:....      ...||:...|....||::.|..|||.|...
  Rat   594 EEKESTELRAEEIETRVTSGSMEALNLTQ------LRKRGSIPTSLTALSLASASPPLSGRSTPK 652

  Fly   547 AGDRNSCSNDSGLRNSSDRESTGGELNFSDGTCDNGPCITVDPD-------SISLVS-SQNMYQF 603
            ...|::         :.|.:..|              .:|:..|       .:|.|| .:|....
  Rat   653 LTSRSA---------AQDLDRMG--------------VMTLPSDLRKHRRKLLSPVSREENREDK 694

  Fly   604 GTPK-ERSPTLSPLNSAAYSRSVEQLGSPVDPEGPGNGAISRKFANASKSGP------LGARNGR 661
            .|.| |.||..||     .:..:|:||.|...:..|..|:..:.:|.|.|..      .||:  |
  Rat   695 ATIKCETSPPSSP-----RTLRLEKLGHPTLSQEEGKSALEGQDSNPSSSNSSQDSLHKGAK--R 752

  Fly   662 GGTWGSISRVFARSRNKNKAL----SADGVTEYADYSWN------PLTEEGYAEKLRLLREASQL 716
            .|...||.|:|.: :.|.:.:    .|.|.....|...:      |......|||.|.|::..||
  Rat   753 KGIKSSIGRLFGK-KEKGRLIHLSRDATGHVLLTDSELSLQEPMVPAKLGTQAEKDRRLKKKHQL 816

  Fly   717 ---------PIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHPM 771
                     |..:|....|::|||:.:|||. |.|.|..|||||.::..|:|.|::..:|:::.:
  Rat   817 LEDARRKGMPFAQWDGPTVVSWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNAL 881

  Fly   772 HRKKLRLAIEEQ---------------------RRPEMVRYPLITQ----------------LGH 799
            ||.||||||:|.                     ...||......|:                :.|
  Rat   882 HRLKLRLAIQEMVSLTSPSAPPTSRTSSGNVWVTHEEMETLATSTKTDSEEGSWAQTLAYGDMNH 946

  Fly   800 TWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKELEKFLGVTRKFHQASIVHGIHVLRIVKY 864
            .|:..||||.:|||||...|::.||||||||.|:||:|...|.:...||:.|:.:||..|:.:.|
  Rat   947 EWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRVHLKMVDSFHRTSLQYGIMCLKRLNY 1011

  Fly   865 DRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGEYADNLKDSGVHGGLVVLEPSFSGDTMA 929
            ||:.|..||.:|:....|.:||||.:.:.||:||.|.:||.||.:|||||.|:.|:.:|..:|:|
  Rat  1012 DRKELEKRREESQHEIKDVLVWTNDQVVHWVQSIGLRDYAGNLHESGVHGALLALDENFDHNTLA 1076

  Fly   930 TALGIPPSKNIIRRHLNTEFDALILPARATLGQGIRSGCGVVPLTGPGGLQHYATTDRRSSGN-- 992
            ..|.||......|:.:..||:.|:     .||                       |||:....
  Rat  1077 LVLQIPTQNTQARQVMEREFNNLL-----ALG-----------------------TDRKLDDGEE 1113

  Fly   993 ---LRISAWKGSQSSLSKAFRFNSKPHRTGDRSSFGNSTSPTPSYSSSEGGGGIYATIGHQYPNP 1054
               .|..:|:.         ||..:.|.:|  ...|.|....|:       |...:|:|
  Rat  1114 KVFRRAPSWRK---------RFRPRDHHSG--GMLGTSAETLPA-------GFRVSTLG------ 1154

  Fly  1055 HTNLQQQHYHHFLPPPTTAPPP--IPSAGGIYSHGPPPGHRVSA 1096
              .||        |||  |||.  :|.|...|.:    ||.:||
  Rat  1155 --PLQ--------PPP--APPNKIMPEAHSHYLY----GHMLSA 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	TBPIP	<341..437	CDD:284512	32/144 (22%)
		SAM_kazrin_repeat1	718..787	CDD:188963	29/90 (32%)
		SAM	719..781	CDD:197735	27/62 (44%)
		SAM_kazrin_repeat2	796..860	CDD:188966	30/79 (38%)
		SAM	805..860	CDD:197735	28/54 (52%)
		SAM_kazrin_repeat3	882..953	CDD:188969	30/70 (43%)
		SAM	885..>934	CDD:197735	24/48 (50%)
Ppfia4	NP_536334.1	Lebercilin	174..355	CDD:292252	36/214 (17%)
		GBP_C	<258..470	CDD:303769	46/212 (22%)
		coiled coil	437..449	CDD:293879	2/11 (18%)
		coiled coil	459..470	CDD:293879	2/10 (20%)
		SAM_liprin-alpha1,2,3,4_repeat1	827..897	CDD:188961	29/69 (42%)
		SAM	827..893	CDD:197735	28/65 (43%)
		SAM_liprin-alpha1,2,3,4_repeat2	944..1009	CDD:188964	31/64 (48%)
		SAM	952..1007	CDD:197735	28/54 (52%)
		SAM_liprin-alpha1,2,3,4_repeat3	1029..1100	CDD:188967	30/70 (43%)
		SAM	1030..1101	CDD:197735	30/75 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910