Protein Alignment Liprin-gamma and Liprin-alpha

DIOPT Version :10

• Sequence 1: NP_001097414.1
• Gene: Liprin-gamma / 37552
• FlyBaseID: FBgn0034720
• Length: 1152
• Species: Drosophila melanogaster
• Sequence 2: XP_061502902.1
• Gene: Liprin-alpha / 1281705
• VectorBaseID: AGAMI1_007168
• Length: 1208
• Species: Anopheles gambiae
• Alignment Length: 1221
• Identity: 289/1221 - (23%)
• Similarity: 446/1221 - (36%)
• Gaps: 397/1221 - (32%)

  Fly    31 SLHKLGESKIAKSLDTSVSTGLKEKAASVNNNKPIRPLLSLDSSVTASTSSGATGSGGGGAPAKP 95
            |||:    :||.:|....||..||...:...      ||..|..:           |...|....
Mosquito    72 SLHR----QIAANLPQEFSTLTKELTQARET------LLERDEEI-----------GELKAERNN 115

  Fly    96 SPLVLASKRDLTPSNESS----------SSPSSSNGSNQTLTPPMTADNQPLQQQLQHH------ 144
            :.|:|.....|...:|.|          :|.|..:...:.|        :.|:...:||
Mosquito   116 TRLLLEHLECLVSRHERSLRMTVVKRQAASQSGVSSEVEVL--------KALKSLFEHHKALDEK 172

  Fly   145 -QHRSPAYPGKPAEAAGGVPQQQQQQQQLPNGIGSSHCNSNSNGISSTCNSGTAMIHANNSNLIA 208
             :.|......|..:....:.|.:::.||..:|:.|   |.:...:.|:.....|:.:..
Mosquito   173 VRERLRISLEKNNDLEAELNQTKEELQQYKSGVLS---NQSDPSLDSSSEKKDALKNGE------ 228

  Fly   209 AGHLAQAAGPAHNAPSSGSALNAVDKRNANLSEPDQ---DLPPNLNVNLSPNPSLALGAPHSPTS 270
            ||.:...:...|...:      .::|:.|.||:..:   ||  |..:|...:....|...::.:.
Mosquito   229 AGEMIDYSAKTHELQT------IIEKQTAELSQWQRRVSDL--NTKINEMEDNMCKLQKEYTKSQ 285

  Fly   271 AASAALL--LLESCDGNRNDESRFHHLH----SAPRPEATMKLREENDRLNAELLRLRRLLELST 329
            .|...|.  |.|:.....:.|.|...|.    :|.| |:| .|.:.|::|..||......|:|.
Mosquito   286 EACVKLQRDLRENVAQKEDQEERIATLEKRYLNAQR-EST-SLHDLNEKLEQELRHKEAQLKLQ- 347

  Fly   330 DGAVGGV--------------DTAPEME--------------AVASGEGSAAKERIERLESELRS 366
            :|.:..:              ...||||              ..|.....:|::||.|||:.:..
Mosquito   348 EGKIAAIQEKLELSEQKLAQFSKLPEMEEQLKARMEALTQVGKQAQERHGSAEDRITRLENNVEE 412

  Fly   367 VK------NQLLTMRLERK--------KLRTDKSDLLG-QVKQLCASLQEKE---QELRDFIRNY 413
            ..      ||.|.|..|..        ||..:.:|.|. .:|:...:|:||.   ||| |..|.|
Mosquito   413 KNAEVMRLNQRLKMNEEHNQRLSSTVDKLLAESNDRLQVHLKERMTALEEKNTLTQEL-DKARKY 476

  Fly   414 QE----------------------------------RVRETETTNAKIS---------------- 428
            .|                                  .:::||.....:|
Mosquito   477 AEELCQEKSDMLKEIAKNRLEMETFKRQILQQEIAYNIQQTEALTRSLSPNAVGNPSANSGFSRS 541

  Fly   429 --------------------------GDRDRERFQLLKQAR----------DEAER--------- 448
                                      .::|..:.|.:..|:          |||:.
Mosquito   542 GSATFSTHSLRRNKSTLEEEHFNRSMAEQDWNKLQHMTNAQVFDGGVLEGADEADNLFGTGDIIS 606

  Fly   449 ----------SLALAQQLSARDLQLQRLQEQLQ--EARRQLTGCLSDQESLHSFAPLTPPSAASG 501
                      ::.|.:||.|.:.:::.:||:.|  |||         .|.|.|         ..|
Mosquito   607 PTGHTDAQTLAIMLQEQLDAINNEIRLIQEEKQSTEAR---------AEELES---------RVG 653

  Fly   502 MLSQMAAASGMGGGLAGMRGTTEDSGRGNSLSAFSGSLSGGSGATAGDR---------------- 550
            .|..|...:                 ||.|:...|..|||.|...:.:|
Mosquito   654 SLEHMNLLA-----------------RGRSMDRQSPPLSGSSTPNSPNRDYLQKYHTAPASMSPA 701

  Fly   551 ---------NSCSNDSGLRNS-------------SDRESTGGELNFSDGTC--DNGPCITVDPD- 590
                     |.......|.:|             .|..:...:::.|.|.|  ||....|:.|.
Mosquito   702 HLHQYVTTLNQVPLSESLPSSQVQLAHLQSEMQHDDMGNADHDMSASGGVCGGDNSSGGTISPAT 766

  Fly   591 ---------SISLVSSQNMYQ-------FGT--PKE--------RSPTLSPLNSAAYSRS----- 624
                     :::|..||...:       .||  |.|        .:..:|||||...|:.
Mosquito   767 ARTMRLERFALALAHSQEELKRRSQGVVHGTEFPNESRNHFVASSNYGMSPLNSRHGSQESLKHL 831

  Fly   625 --VEQLGSPVDPEGPGNGAISRKFANASKSG-PLGARNGRGGTWGSISRVFARSRNKNKALS--- 683
              |..|.|...|             .||:.| .:.|...:.|...|:.|.|:: :.|.|.:.
Mosquito   832 SMVSSLSSLQTP-------------TASRGGDAVSAAQKKKGIKSSLGRFFSK-KEKVKGVKDSS 882

  Fly   684 -ADGVTEY-----------ADYSWNPLTEEGY------------AEKLR-------LLREASQ-- 715
             .||.|..           .|.:::.::..||            .:|.:       ||.||.:
Mosquito   883 MPDGSTSMMSMSGLSLISDIDSTYDNISVSGYRPPGKSNPIDYTRQKKKEHDYRHDLLGEAMKAG 947

  Fly   716 LPIDRWRATQVLAWLEVALGMPQ-YSARCAENVKSGKVLLELNDVELEAGLGLAHPMHRKKLRLA 779
            .|...|....::||||:.:|||. |.|.|..|||||.::..|:|.|::..:|:::|:||.|||||
Mosquito   948 TPFALWNGPTIVAWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLA 1012

  Fly   780 IEEQ------RRPEMVRYPL-ITQLGHTWVATEWLPDIGLPQYAEPFVQSLVDARMLDTLSKKEL 837
            |:|.      ..|:..|..| ...:.|.|:...|||.:|||||...|::.||||||||.|:||:|
Mosquito  1013 IQEMVSLTSPSAPQTTRTTLAFGDMNHEWIGNYWLPSLGLPQYRTTFMECLVDARMLDHLNKKDL 1077

  Fly   838 EKFLGVTRKFHQASIVHGIHVLRIVKYDRQTLAMRRVQSETVDTDPIVWTNQRFIRWVRSIDLGE 902
            ...|.:...||:.|:..||..|:.:.|||..|..||..||...:|.:||||.|.:|||:|:.|.|
Mosquito  1078 RGQLKMVDSFHRTSLQFGISCLKRLNYDRAALQERRKASENSLSDVLVWTNDRTMRWVQSVGLKE 1142

  Fly   903 YADNLKDSGVHGGLVVLEPSFSGDTMATALGIPPSKNIIRRHLNTEFDALI 953
            ||:||.:||:||.|:.|:.||..::||.||.||......|:.|.|||:.|:
Mosquito  1143 YANNLLESGIHGALIALDESFDANSMALALQIPTQNTQARQILGTEFNKLL 1193

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Liprin-gamma	NP_001097414.1	COG4372	<346..>460	CDD:443500	40/236 (17%)
		SAM_kazrin_repeat1	718..787	CDD:188963	30/75 (40%)
		SAM_kazrin_repeat2	796..860	CDD:188966	29/63 (46%)
		SAM_kazrin_repeat3	882..953	CDD:188969	35/70 (50%)
Liprin-alpha	XP_061502902.1	None