Protein Alignment KCNG1 and Shawl

DIOPT Version :9

• Sequence 1: NP_002228.2
• Gene: KCNG1 / 3755
• HGNCID: 6248
• Length: 513
• Species: Homo sapiens
• Sequence 2: NP_001097131.2
• Gene: Shawl / 5740840
• FlyBaseID: FBgn0085395
• Length: 937
• Species: Drosophila melanogaster
• Alignment Length: 557
• Identity: 151/557 - (27%)
• Similarity: 235/557 - (42%)
• Gaps: 177/557 - (31%)

Human    60 DRRRRIIINVGGIKYSLPWTTLDEFPLTRLGQL-KACTNFDDILNVCDDYDVTCNEFFFDRNPGA 123
            |...|||:||.||:|.....||.:.|.|||.:| :|..|:|.:|          ||:||||:||.
  Fly     2 DGENRIILNVSGIRYETYKATLKKIPATRLSRLTEALANYDPVL----------NEYFFDRHPGV 56

Human   124 FGTILTFLRAGKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVEREEED-- 186
            |..||.:.|.|||....::|...|:|||.:||:..:.::.||...|         .:.|:.::
  Fly    57 FTQILNYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTY---------SIHRDTQNTL 112

Human   187 ---DALDSEGRDSEGPAE-------------GEGRLGRCMRRLRD----MVERPHSGLPGKVFAC 231
               |.||.|   :|.|.|             ..|.| .|.:|::.    |.:.|.|....|:.|.
  Fly   113 AILDKLDIE---NEKPTEEQIARLFGFEEALSNGEL-NCWQRIKPKIWAMFDEPSSSTGAKIVAG 173

Human   232 LSVLFVTVTAVNLSVSTLPSLR------------------------------------------- 253
            :||.|:.|:.::..:.|.|..|
  Fly   174 MSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPS 238

Human   254 -----------------------------------------------------EEEEQGHCSQMC 265
                                                                 ||:..||..:..
  Fly   239 GSIGPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRK 303

Human   266 HN-----------VFIVESVCVGWFSLEFLLRLIQAPSKFAFLRSPLTLIDLVAILPYYITLLVD 319
            |.           .|.||.||..||.:|.::|||.:|:.:.|::||:.:||..|.|.:|..::
  Fly   304 HGWIETYGQPHEAFFYVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDVM-- 366

Human   320 GAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTARRCTREFGLLLLFL 384
                  ::.|.....|:...:|       ||:.:.:|.|||.||:.|..|.:...:|..||:.||
  Fly   367 ------QRMGEYTGLLEAFSIV-------RIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFL 418

Human   385 CVAIALFAPLLYVIENEMADSP--EFTSIPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILS 447
            .:.|..||.|.|..| ::.|:|  :|.|||...|||::|||||||||:.|::.||..|.....|:
  Fly   419 VLGIVFFASLAYYAE-KLQDNPDNQFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALA 482

Human   448 GILLMAFPVT------SIFHTFSRSYLELKQEQERVM 478
            |:|.:|.||.      |:|::.:::..:|.:::.||:
  Fly   483 GVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KCNG1	NP_002228.2	BTB_POZ_KCNG1_2	60..173	CDD:349728	45/113 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..204		7/37 (19%)
		Ion_trans	227..471	CDD:395416	88/358 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	424..429		4/4 (100%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	41/101 (41%)
		BTB_2	7..97	CDD:280393	40/99 (40%)
		Ion_trans	307..506	CDD:278921	74/214 (35%)
		Ion_trans_2	<449..499	CDD:285168	22/49 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810