Protein Alignment Gp150 and Igfals

DIOPT Version :10

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_445781.3
• Gene: Igfals / 79438
• RGDID: 68429
• Length: 603
• Species: Rattus norvegicus
• Alignment Length: 620
• Identity: 150/620 - (24%)
• Similarity: 246/620 - (39%)
• Gaps: 109/620 - (17%)

  Fly   245 TDDEQVVFSEDVPCPRFCQCAR-NVNSYLVATCSRLDMGIQKFGSDITDLVVTNVGPKYPILMGP 308
            ||......:|...||..|.|:. :....|...||..::              |::....|:....
  Rat    28 TDPGASADAEGPQCPVACTCSHDDYTDELSVFCSSKNL--------------THLPDDIPVSTRA 78

  Fly   309 NFFQNLGLKNVASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTIS 373
            .:...   .|::||..|          ||..|:.|..:||....|..:.|...:|.:.|..|.:.
  Rat    79 LWLDG---NNLSSIPSA----------AFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLE 130

  Fly   374 GNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFE--- 435
            .|.|..: ::.....:.|:..|..|.|.|..|....|..||::..:||..|||..||:..|:
  Rat   131 RNRLRNL-AVGLFTHTPSLASLSLSSNLLGRLEEGLFQGLSHLWDLNLGWNSLVVLPDTVFQGLG 194

  Fly   436 ----------KVTLLE-----------ELDLSYNSLTELPRDIF-NGTTLSILHLKYNTFNG--- 475
                      |:|.|:           |||||.|:|..:..::| :...|..|:|..|....
  Rat   195 NLHELVLAGNKLTYLQPALFCGLGELRELDLSRNALRSVKANVFVHLPRLQKLYLDRNLITAVAP 259

  Fly   476 DLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSIN 540
            ....|.|.|:.||||.|.:..:....|..:.||..|.|..|.|..::|.:|..|..|..:.|..|
  Rat   260 RAFLGMKALRWLDLSHNRVAGLMEDTFPGLLGLHVLRLAHNAIASLRPRTFKDLHFLEELQLGHN 324

  Fly   541 DLDQISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDIS-NCAIG-P------- 596
            .:.|:....|....:|:|:.|||| :::::....|   ||.|.|..:::| ||... |
  Rat   325 RIRQLGERTFEGLGQLEVLTLNDN-QITEVRVGAF---SGLFNVAVMNLSGNCLRSLPERVFQGL 385

  Fly   597 ------------LGHKAFSTMPHLTTLK---LAWNNINHLPREIFTGLHKLIDLDLSNNLITRMD 646
                        |||....|...|:.|:   |..|:|:.:..:...||.:|::|||:.|.:|.:.
  Rat   386 DKLHSLHLEHSCLGHVRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTTNRLTHLP 450

  Fly   647 DLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDS--- 708
            ..:|...|.|..|.|:.|.::.||..:..||.:...||::...|.||...        :|.|
  Rat   451 RQLFQGLGHLEYLLLSYNQLTTLSAEVLGPLQRAFWLDISHNHLETLAEG--------LFSSLGR 507

  Fly   709 LRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEFISYVTLQMQMTPKRLPVLANL 773
            ||..:...|.::..|.:     ..|..|.:..||..|:...:....:......:.|:.:..:...
  Rat   508 LRYLSLRNNSLQTFSPQ-----PGLERLWLDANPWDCSCPLKALRDFALQNPGVVPRFVQTVCEG 567

  Fly   774 EDDATIVQLETLAQAGWSSLAHEVCKHAEGSDLLD 808
            :|...:.....:..||.::::        |.||.|
  Rat   568 DDCQPVYTYNNITCAGPANVS--------GLDLRD 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR	341..758	CDD:443914	123/471 (26%)
		leucine-rich repeat	343..366	CDD:275380	6/22 (27%)
		leucine-rich repeat	367..391	CDD:275380	4/23 (17%)
		leucine-rich repeat	393..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..439	CDD:275380	9/35 (26%)
		leucine-rich repeat	440..483	CDD:275380	14/57 (25%)
		leucine-rich repeat	463..481	CDD:275380	4/20 (20%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		leucine-rich repeat	508..531	CDD:275380	8/22 (36%)
		leucine-rich repeat	532..569	CDD:275380	11/36 (31%)
		leucine-rich repeat	556..583	CDD:275380	9/26 (35%)
		leucine-rich repeat	570..607	CDD:275380	13/57 (23%)
		leucine-rich repeat	608..631	CDD:275380	7/25 (28%)
		leucine-rich repeat	632..655	CDD:275380	7/22 (32%)
		leucine-rich repeat	656..674	CDD:275380	6/17 (35%)
		leucine-rich repeat	733..745	CDD:275378	4/11 (36%)
Igfals	NP_445781.3	LRRNT	40..78	CDD:214470	9/51 (18%)
		leucine-rich repeat	57..75	CDD:275380	4/31 (13%)
		LRR 1	75..96		6/33 (18%)
		leucine-rich repeat	79..99	CDD:275380	7/32 (22%)
		LRR	85..476	CDD:443914	112/405 (28%)
		LRR 2	99..120		5/20 (25%)
		leucine-rich repeat	103..123	CDD:275380	5/19 (26%)
		LRR 3	123..144		4/21 (19%)
		LRR 4	147..168		7/20 (35%)
		LRR 5	171..192		8/20 (40%)
		leucine-rich repeat	175..195	CDD:275380	8/19 (42%)
		LRR 6	195..216		3/20 (15%)
		leucine-rich repeat	196..219	CDD:275380	3/22 (14%)
		LRR 7	219..240		8/20 (40%)
		leucine-rich repeat	220..243	CDD:275380	8/22 (36%)
		LRR 8	243..264		4/20 (20%)
		leucine-rich repeat	244..267	CDD:275380	5/22 (23%)
		LRR 9	267..288		7/20 (35%)
		leucine-rich repeat	268..291	CDD:275380	7/22 (32%)
		LRR 10	291..312		8/20 (40%)
		leucine-rich repeat	292..315	CDD:275380	8/22 (36%)
		LRR 11	315..336		5/20 (25%)
		leucine-rich repeat	316..339	CDD:275380	5/22 (23%)
		LRR 12	339..360		7/24 (29%)
		leucine-rich repeat	340..363	CDD:275380	9/26 (35%)
		LRR 13	363..384		5/20 (25%)
		leucine-rich repeat	364..387	CDD:275380	5/22 (23%)
		LRR 14	387..408		4/20 (20%)
		leucine-rich repeat	388..411	CDD:275380	5/22 (23%)
		LRR 15	411..432		4/20 (20%)
		leucine-rich repeat	412..435	CDD:275380	6/22 (27%)
		LRR 16	435..456		7/20 (35%)
		leucine-rich repeat	436..459	CDD:275380	7/22 (32%)
		LRR 17	459..480		6/20 (30%)
		leucine-rich repeat	460..481	CDD:275380	6/20 (30%)
		LRR 18	483..504		6/28 (21%)
		leucine-rich repeat	484..507	CDD:275380	7/30 (23%)
		LRR_8	486..536	CDD:404697	13/62 (21%)
		LRR 19	507..528		4/25 (16%)
		LRRCT	535..578	CDD:214507	5/42 (12%)