DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gp150 and Tollo

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	584	Identity:	139/584 - (23%)
Similarity:	235/584 - (40%)	Gaps:	167/584 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 MGPNFFQNLGLKNVASIKIANCTLEY-----LHAEAFHGLNELYAVNLT---------------- 349
            :.|:.|::|       :::.:.|:||     |...:|.||.||.  |||
  Fly    89 LSPDSFRSL-------VELRDLTIEYCKLGNLTDGSFRGLQELR--NLTIRTHNGDWSTMSLEMA 144

  Fly   350 -----------DVGLAIIN----PDTFV-GNKKLRMLTISGNDLSVMSSIHYLLKSSS------- 391
                       .:.|::.|    ||..| ..|.|:.|..|.|.:..:|:.::....||
  Fly   145 SNSFVEFRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCG 209

  Fly   392 --IEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELP 454
              ::.||.|.|.::.|.....|.|..:.::|:::||:..|.::|||.:..|..:|||.|.||.||
  Fly   210 STLQSLDLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLP 274

  Fly   455 RDIFNGT-TLSILHLKYNTFN-------GDL----------------------HFGTKDLQQLDL 489
            .::|..| .|..::|:.|:.|       |:|                      ..|.|.|..|||
  Fly   275 PELFAETKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDL 339

  Fly   490 SFNSIVQVHHSMF----------------DKMPG-----LTNLN---LKGNGIKKIQPDSFLTLK 530
            |.|.|.::...:|                |::||     ||||:   |..|.|..|:..:...||
  Fly   340 SANKISRLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLK 404

  Fly   531 NLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIG 595
            ||..:.|..|.:.::........|:|..:.|||| :|..:|.    :.:....:..||:....|.
  Fly   405 NLLVLSLDFNRISRMDQRSLVNCSQLQDLHLNDN-KLQAVPE----ALAHVQLLKTLDVGENMIS 464

  Fly   596 PLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLS 660
            .:.:.:.:.:..|..|::..|::.|:.|.:|..:..|..|:||.|.:..::......|.:|..:.
  Fly   465 QIENTSITQLESLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGSLQRNSQLQAIR 529

  Fly   661 LAGNPISRLSVRLFLPLHQ----------------------LRCLDVNDCELTTLLSDRDLGAGY 703
            |.||.:..:: .||..|..                      |:.|||....:|      .||..:
  Fly   530 LDGNQLKSIA-GLFTELPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRIT------QLGNYF 587

  Fly   704 KIFD--SLRSFNASGNLIKKISSEDVKS--------------------FK--NLRSLDITNNPL 743
            :|..  ||.:|:||.||:.:|::..:.:                    ||  ||..:|:..|.|
  Fly   588 EIESELSLSTFDASYNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRL 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	22/96 (23%)
		leucine-rich repeat	343..366	CDD:275380	9/54 (17%)
		leucine-rich repeat	367..391	CDD:275380	5/23 (22%)
		LRR_RI	<374..619	CDD:238064	76/307 (25%)
		LRR_8	390..450	CDD:290566	21/68 (31%)
		leucine-rich repeat	393..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..483	CDD:275380	18/72 (25%)
		leucine-rich repeat	463..481	CDD:275380	6/46 (13%)
		LRR_8	484..542	CDD:290566	25/81 (31%)
		leucine-rich repeat	484..507	CDD:275380	9/38 (24%)
		leucine-rich repeat	508..531	CDD:275380	9/25 (36%)
		leucine-rich repeat	532..569	CDD:275380	10/36 (28%)
		leucine-rich repeat	556..583	CDD:275380	7/26 (27%)
		leucine-rich repeat	570..607	CDD:275380	4/36 (11%)
		LRR_RI	<586..745	CDD:238064	45/204 (22%)
		LRR_8	606..666	CDD:290566	16/59 (27%)
		leucine-rich repeat	608..631	CDD:275380	6/22 (27%)
		leucine-rich repeat	632..655	CDD:275380	6/22 (27%)
		leucine-rich repeat	656..674	CDD:275380	4/17 (24%)
		leucine-rich repeat	733..745	CDD:275378	4/11 (36%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	52/200 (26%)
		leucine-rich repeat	100..123	CDD:275380	7/22 (32%)
		leucine-rich repeat	124..144	CDD:275380	4/21 (19%)
		LRR_8	152..222	CDD:290566	17/69 (25%)
		leucine-rich repeat	154..177	CDD:275380	5/22 (23%)
		leucine-rich repeat	178..201	CDD:275380	5/22 (23%)
		LRR	210..656	CDD:227223	111/454 (24%)
		leucine-rich repeat	212..235	CDD:275380	7/22 (32%)
		leucine-rich repeat	236..259	CDD:275380	7/22 (32%)
		leucine-rich repeat	260..283	CDD:275380	11/22 (50%)
		LRR_RI	276..558	CDD:238064	65/287 (23%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	1/24 (4%)
		leucine-rich repeat	334..357	CDD:275380	8/22 (36%)
		leucine-rich repeat	358..381	CDD:275380	4/22 (18%)
		leucine-rich repeat	382..405	CDD:275380	6/22 (27%)
		leucine-rich repeat	406..429	CDD:275380	3/22 (14%)
		leucine-rich repeat	430..452	CDD:275380	7/26 (27%)
		leucine-rich repeat	453..500	CDD:275380	9/46 (20%)
		leucine-rich repeat	501..521	CDD:275380	5/19 (26%)
		leucine-rich repeat	525..547	CDD:275380	7/22 (32%)
		leucine-rich repeat	548..573	CDD:275380	1/24 (4%)
		leucine-rich repeat	604..640	CDD:275380	4/35 (11%)
		leucine-rich repeat	641..688	CDD:275380	4/11 (36%)
		leucine-rich repeat	689..816	CDD:275380
		LRR_8	815..875	CDD:290566
		leucine-rich repeat	817..864	CDD:275380
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010