DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gp150 and 2mit

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001262529.1	Gene:	2mit / 41616	FlyBaseID:	FBgn0260793	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	611	Identity:	149/611 - (24%)
Similarity:	217/611 - (35%)	Gaps:	183/611 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   322 IKIAN--CTLEYLHAEAFHGLNEL-YAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMS-- 381
            :||.|  |.|......|:..|..| .|.:|.|:..:    ......::.:.|  |..|:..:|
  Fly     2 VKIVNQHCDLGLALLLAWTWLTRLVVAAHLVDIPTS----SRLAAEREEQQL--SRQDVGRLSYQ 60

  Fly   382 SIHYLLKSSSIEELDFSRNNL----------MELNPKAFSHLSNVVYINLSQNSLKKLPEKA--- 433
            |||.:|:..:  |.|..|..|          :|||..|..       :||:...|:......
  Fly    61 SIHRMLRDEN--EPDSFRGELRYQQKRHKRELELNAPANK-------LNLTHRDLRTFNSTGGQW 116

  Fly   434 ---FEKVTLLEELDLSYNSLTELPRDIFN--------GTTLSILHLKYNTFNGDLHFGTKDLQQL 487
               |:.:|   .:|||.|.|..|..|.||        ..:|.::.|.....|..|.|.|     |
  Fly   117 KGDFQVIT---AMDLSSNQLESLSLDNFNQLRQLDLGNNSLEVIPLSLADTNMSLPFVT-----L 173

  Fly   488 DLSFNSIVQVHHSMF-DKMPGLTNLN------------------------LKGNGIKKIQPDSFL 527
            |||.|...|:..|.| .::|.|.|||                        |..|.|..|..::||
  Fly   174 DLSCNKFSQISTSFFAQRLPQLKNLNLAHNELLNISRESFYNLLELQTLVLSHNNISDIDYETFL 238

  Fly   528 TLKNLRHIDLSIN--------------DLDQIS---------GMLFFKNS----ELDVIRLNDNP 565
            .|.||:::|||.|              ||..:|         .|..|..|    |||.    ...
  Fly   239 ALPNLQYLDLSHNRLSGSAIRALQGIPDLVSLSIAYNPDVGVAMQEFVASWSLKELDA----SGT 299

  Fly   566 RLSQLP------------TDGFLS--YSGEFTVY----YLDISNCAIGPLGHKAF---------- 602
            .|.|:|            :|.:|.  ..|:...|    |||:|:..|..:...|.
  Fly   300 GLCQVPAALAQSVRTLKLSDNWLKAINCGDMDSYPLLQYLDLSHSRIAQVEDDALGRLELLESLF 364

  Fly   603 -----------STMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGEL 656
                       |..|.|..|.|..|.|..||.:.|.||..|..||||||      .|||:....|
  Fly   365 LDRNLLMRVPSSLPPSLEHLFLQHNQIMELPPQAFVGLVNLQTLDLSNN------RLIFLPPLSL 423

  Fly   657 TK---LSLAGNPISRLSVRLFLPLHQLR--CLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNAS- 715
            .|   |:|..:.:..:|..:...|.|||  .|:.|..:.:.||...:..:..:..|:.:|..||
  Fly   424 PKLLTLNLESSGVESVSQSIVHTLPQLRDLLLEDNPIKCSDLLGIAEWASPCRSVDAGQSNGASV 488

  Fly   716 -------------GNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEFISYVTLQMQMTPKRL 767
                         .|..:..||.:.    .:|..:....|..|:      ::..:..:..||:.:
  Fly   489 SGRVDLKTEYLQFHNFYENFSSREC----GIRKPENDTKPPSCS------LTRASATLTTTPRSM 543

  Fly   768 -PVLANLEDDATIVQLETLAQAGWSS 792
             .|..:.|..||...:|..|....:|
  Fly   544 SKVEKSQEAQATATSVEVAAATAATS 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	13/57 (23%)
		leucine-rich repeat	343..366	CDD:275380	4/23 (17%)
		leucine-rich repeat	367..391	CDD:275380	8/25 (32%)
		LRR_RI	<374..619	CDD:238064	88/361 (24%)
		LRR_8	390..450	CDD:290566	17/75 (23%)
		leucine-rich repeat	393..415	CDD:275380	8/31 (26%)
		leucine-rich repeat	416..439	CDD:275380	4/28 (14%)
		leucine-rich repeat	440..483	CDD:275380	15/50 (30%)
		leucine-rich repeat	463..481	CDD:275380	5/17 (29%)
		LRR_8	484..542	CDD:290566	26/96 (27%)
		leucine-rich repeat	484..507	CDD:275380	8/23 (35%)
		leucine-rich repeat	508..531	CDD:275380	11/46 (24%)
		leucine-rich repeat	532..569	CDD:275380	15/63 (24%)
		leucine-rich repeat	556..583	CDD:275380	8/40 (20%)
		leucine-rich repeat	570..607	CDD:275380	12/75 (16%)
		LRR_RI	<586..745	CDD:238064	50/198 (25%)
		LRR_8	606..666	CDD:290566	25/62 (40%)
		leucine-rich repeat	608..631	CDD:275380	10/22 (45%)
		leucine-rich repeat	632..655	CDD:275380	10/22 (45%)
		leucine-rich repeat	656..674	CDD:275380	5/20 (25%)
		leucine-rich repeat	733..745	CDD:275378	2/11 (18%)
2mit	NP_001262529.1	LRR_RI	124..355	CDD:238064	64/242 (26%)
		leucine-rich repeat	124..143	CDD:275380	9/21 (43%)
		leucine-rich repeat	144..167	CDD:275380	3/22 (14%)
		leucine-rich repeat	172..194	CDD:275380	9/26 (35%)
		LRR_8	193..253	CDD:290566	18/59 (31%)
		leucine-rich repeat	195..218	CDD:275380	4/22 (18%)
		leucine-rich repeat	219..242	CDD:275380	7/22 (32%)
		LRR_8	241..301	CDD:290566	15/63 (24%)
		leucine-rich repeat	243..311	CDD:275380	17/71 (24%)
		leucine-rich repeat	312..335	CDD:275380	4/22 (18%)
		LRR_8	334..415	CDD:290566	25/86 (29%)
		leucine-rich repeat	336..359	CDD:275380	6/22 (27%)
		leucine-rich repeat	360..380	CDD:275380	1/19 (5%)
		LRR_8	379..460	CDD:290566	32/86 (37%)
		LRR_4	379..>415	CDD:289563	18/41 (44%)
		leucine-rich repeat	381..404	CDD:275380	10/22 (45%)
		leucine-rich repeat	405..449	CDD:275380	16/49 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010