DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp150 and Con

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	633	Identity:	126/633 - (19%)
Similarity:	212/633 - (33%)	Gaps:	235/633 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 KNVASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDT----FVGNKKLRML--TISGN 375
            :|...::.|.|   ::.:|..|                  ..||    |...|:||.|  .|..|
  Fly   125 ENHVPVQKAEC---WVFSEGLH------------------QNDTTWTRFYQQKRLRELKFVIQNN 168

  Fly   376 DLSVMSSIHYL-------LKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKA 433
                 :.:.|:       ||:.|...:::|:..:::  ..||::|..:..|.|:.|.:..|.:.|
  Fly   169 -----ARLDYIPTMIIEPLKNLSSIVIEYSQVEIVK--SYAFANLPFLERIILNNNHIMALDQDA 226

  Fly   434 FEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVH 498
            |.....|.||:|.:|.:.|:.|..|....|                    .::|.|:.|:|..:|
  Fly   227 FANHIRLRELNLEHNQIFEMDRYAFRNLPL--------------------CERLFLNNNNISTLH 271

  Fly   499 HSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLND 563
            ..:|..|..||.|||..|.|..:..:.|..|.||..:.|:.|:|:.|...:|.:...|..:.|:|
  Fly   272 EGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDD 336

  Fly   564 N--PRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIF 626
            |  .|:|:...||                                 |.|||
  Fly   337 NRIERISERALDG---------------------------------LNTLK-------------- 354

  Fly   627 TGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPL--------HQLRCL 683
                   .|:|.|||:.::|:.:......|..:::..|.:..|:...|.|:        .:|...
  Fly   355 -------TLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVS 412

  Fly   684 D---VNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKC 745
            |   :.||.|..:...::.....::.|||               ||                |.|
  Fly   413 DNKFICDCRLQWIFELKNRTRHLQLRDSL---------------ED----------------LHC 446

  Fly   746 TPDFQEFISYVTLQMQMTPKRLPVLANLEDDATIVQLETLAQAGWSSLAHE-----------VCK 799
            |  .||                |.|::..|......|:.|...|::::...           |..
  Fly   447 T--LQE----------------PKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGS 493

  Fly   800 HAEGSDLLDEKK----------------ADSAEAKLEKRLKESVKKLNEDEAKLLSVLDKSVLDK 848
            ...|..:.|.:|                |.|||..:|.:::...|:..|.:.|.|:.:
  Fly   494 SYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAV------- 551

  Fly   849 SRLSSMQKIMKGSVNTETAKPEEDADEENLNNGGE------DKEDDSS 890
                              |...:..|..:.||||.      |.:|:.|
  Fly   552 ------------------APAHKRYDYYDDNNGGMSLGHGLDLDDNLS 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	14/65 (22%)
		leucine-rich repeat	343..366	CDD:275380	3/26 (12%)
		leucine-rich repeat	367..391	CDD:275380	8/32 (25%)
		LRR_RI	<374..619	CDD:238064	59/253 (23%)
		LRR_8	390..450	CDD:290566	16/59 (27%)
		leucine-rich repeat	393..415	CDD:275380	4/21 (19%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..483	CDD:275380	9/42 (21%)
		leucine-rich repeat	463..481	CDD:275380	1/17 (6%)
		LRR_8	484..542	CDD:290566	20/57 (35%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		leucine-rich repeat	508..531	CDD:275380	9/22 (41%)
		leucine-rich repeat	532..569	CDD:275380	11/38 (29%)
		leucine-rich repeat	556..583	CDD:275380	8/28 (29%)
		leucine-rich repeat	570..607	CDD:275380	2/36 (6%)
		LRR_RI	<586..745	CDD:238064	26/169 (15%)
		LRR_8	606..666	CDD:290566	12/59 (20%)
		leucine-rich repeat	608..631	CDD:275380	4/22 (18%)
		leucine-rich repeat	632..655	CDD:275380	6/22 (27%)
		leucine-rich repeat	656..674	CDD:275380	3/17 (18%)
		leucine-rich repeat	733..745	CDD:275378	1/11 (9%)
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	44/170 (26%)
		LRR_8	183..243	CDD:290566	17/61 (28%)
		leucine-rich repeat	185..208	CDD:275380	5/24 (21%)
		leucine-rich repeat	209..232	CDD:275380	6/22 (27%)
		LRR_RI	<225..416	CDD:238064	59/264 (22%)
		LRR_8	232..291	CDD:290566	22/78 (28%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	7/22 (32%)
		leucine-rich repeat	281..304	CDD:275380	9/22 (41%)
		LRR_8	304..363	CDD:290566	23/112 (21%)
		leucine-rich repeat	305..328	CDD:275380	6/22 (27%)
		leucine-rich repeat	329..352	CDD:275380	9/55 (16%)
		LRR_8	352..416	CDD:290566	16/84 (19%)
		leucine-rich repeat	353..376	CDD:275380	8/43 (19%)
		LRRCT	414..>450	CDD:214507	11/68 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100