DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp150 and 18w

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	130/531 - (24%)
Similarity:	214/531 - (40%)	Gaps:	118/531 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 PNFFQNL-GLKNVASIKIANC------TLEYLHAEAFHGLNELYAVNLTD--------------- 350
            ||.|:.| .||.: :::..|.      ||| ||.::|.||.||..::|.|
  Fly   107 PNAFEGLMSLKRL-TLESHNAVWGPGKTLE-LHGQSFQGLKELSELHLGDNNIRQLPEGVWCSMP 169

  Fly   351 -------------------------VGLAIINPDTFV-GNKKLRMLTISGNDLSVMSSIHYLLKS 389
                                     .|.|:.|.:..| |..:|:.|.:|.|:|..:.......:.
  Fly   170 SLQLLNLTQNRIRSAEFLGFSEKLCAGSALSNANGAVSGGSELQTLDVSFNELRSLPDAWGASRL 234

  Fly   390 SSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELP 454
            ..::.|....||:..|.|.|.:.||::..:|:|.|.|..||.:||.....|.||.|..|.|.|||
  Fly   235 RRLQTLSLQHNNISTLAPNALAGLSSLRVLNISYNHLVSLPSEAFAGNKELRELHLQGNDLYELP 299

  Fly   455 RDI-----------FNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGL 508
            :.:           .:|..|:..|:..:||.|.:.     |..|:||.|::.::....|.::..|
  Fly   300 KGLLHRLEQLLVLDLSGNQLTSHHVDNSTFAGLIR-----LIVLNLSNNALTRIGSKTFKELYFL 359

  Fly   509 TNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLPTD 573
            ..|:::.|.|..|:..:||.|.||..::|:.|.|..:...:|
  Fly   360 QILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIF----------------------- 401

  Fly   574 GFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLS 638
                 :|.:.:..|.::|..:..:..:||.....|..|.|:.|.:..:| |....|..|..|||.
  Fly   402 -----NGLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVP-EAVQDLSMLKTLDLG 460

  Fly   639 NNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDV--------------NDCE 689
            .|.|:...:..|.:..:||.|.|..|.|..::|.:|..|.:|..|::              .:.|
  Fly   461 ENQISEFKNNTFRNLNQLTGLRLIDNRIGNITVGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTE 525

  Fly   690 LTTLLSDR----DLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDF- 749
            :..:..|:    |:...:....||...|.|.|.:.......:.|  ||:.|||..|.::...::
  Fly   526 IEAIRLDKNFLTDINGIFATLASLLWLNLSENHLVWFDYAFIPS--NLKWLDIHGNYIEALGNYY 588

  Fly   750 --QEFISYVTL 758
              ||.|...||
  Fly   589 KLQEEIRVTTL 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	23/106 (22%)
		leucine-rich repeat	343..366	CDD:275380	8/63 (13%)
		leucine-rich repeat	367..391	CDD:275380	5/23 (22%)
		LRR_RI	<374..619	CDD:238064	62/255 (24%)
		LRR_8	390..450	CDD:290566	21/59 (36%)
		leucine-rich repeat	393..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..439	CDD:275380	8/22 (36%)
		leucine-rich repeat	440..483	CDD:275380	15/53 (28%)
		leucine-rich repeat	463..481	CDD:275380	5/17 (29%)
		LRR_8	484..542	CDD:290566	18/57 (32%)
		leucine-rich repeat	484..507	CDD:275380	6/22 (27%)
		leucine-rich repeat	508..531	CDD:275380	8/22 (36%)
		leucine-rich repeat	532..569	CDD:275380	5/36 (14%)
		leucine-rich repeat	556..583	CDD:275380	1/26 (4%)
		leucine-rich repeat	570..607	CDD:275380	5/36 (14%)
		LRR_RI	<586..745	CDD:238064	44/176 (25%)
		LRR_8	606..666	CDD:290566	19/59 (32%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		leucine-rich repeat	632..655	CDD:275380	7/22 (32%)
		leucine-rich repeat	656..674	CDD:275380	7/17 (41%)
		leucine-rich repeat	733..745	CDD:275378	5/11 (45%)
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380	4/7 (57%)
		LRR_8	115..181	CDD:290566	15/67 (22%)
		leucine-rich repeat	116..146	CDD:275380	11/31 (35%)
		leucine-rich repeat	147..170	CDD:275380	3/22 (14%)
		leucine-rich repeat	171..201	CDD:275380	2/29 (7%)
		LRR_RI	210..464	CDD:238064	73/287 (25%)
		leucine-rich repeat	212..236	CDD:275380	5/23 (22%)
		LRR_8	235..295	CDD:290566	21/59 (36%)
		leucine-rich repeat	237..260	CDD:275380	7/22 (32%)
		leucine-rich repeat	261..284	CDD:275380	8/22 (36%)
		LRR_8	283..345	CDD:290566	20/66 (30%)
		leucine-rich repeat	285..308	CDD:275380	9/22 (41%)
		leucine-rich repeat	309..334	CDD:275380	6/24 (25%)
		LRR_8	334..393	CDD:290566	18/63 (29%)
		leucine-rich repeat	335..358	CDD:275380	6/22 (27%)
		leucine-rich repeat	359..382	CDD:275380	8/22 (36%)
		LRR_8	382..441	CDD:290566	15/86 (17%)
		leucine-rich repeat	383..406	CDD:275380	6/50 (12%)
		leucine-rich repeat	407..430	CDD:275380	4/22 (18%)
		LRR_8	431..488	CDD:290566	19/57 (33%)
		leucine-rich repeat	431..451	CDD:275380	6/20 (30%)
		leucine-rich repeat	454..477	CDD:275380	7/22 (32%)
		LRR_8	477..559	CDD:290566	19/81 (23%)
		leucine-rich repeat	478..499	CDD:275380	8/20 (40%)
		leucine-rich repeat	502..525	CDD:275380	2/22 (9%)
		leucine-rich repeat	526..548	CDD:275380	2/21 (10%)
		leucine-rich repeat	590..617	CDD:275380	5/10 (50%)
		leucine-rich repeat	618..641	CDD:275380
		leucine-rich repeat	642..689	CDD:275380
		LRRCT	679..736	CDD:214507
		leucine-rich repeat	775..796	CDD:275380
		LRR_8	797..852	CDD:290566
		leucine-rich repeat	797..817	CDD:275380
		leucine-rich repeat	818..841	CDD:275380
		LRR_8	841..900	CDD:290566
		leucine-rich repeat	842..865	CDD:275380
		LRR_4	866..907	CDD:289563
		leucine-rich repeat	866..889	CDD:275380
		leucine-rich repeat	890..911	CDD:275380
		TIR	1045..1183	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010