Protein Alignment Gp150 and IGFALS

DIOPT Version :10

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001139478.1
• Gene: IGFALS / 3483
• HGNCID: 5468
• Length: 643
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 143/561 - (25%)
• Similarity: 219/561 - (39%)
• Gaps: 123/561 - (21%)

  Fly   253 SEDVPCPRFCQCARNVNS-YLVATCS-----RLDMGIQKFGSDITDLVVTNVGPKYPILMGPNFF 311
            :|...||..|.|:.:.:: .|...||     ||..|:                        |...
Human    74 AEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGV------------------------PGGT 114

  Fly   312 QNLGL--KNVASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTISG 374
            |.|.|  .|::|:..|          ||..|:.|..:||....|..:.|...:|.:.|..|.:..
Human   115 QALWLDGNNLSSVPPA----------AFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLER 169

  Fly   375 NDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTL 439
            |.|..: ::.....:.::..|..|.|.|..|....|..|.::..:||..|||..||:.||..:..
Human   170 NQLRSL-ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 233

  Fly   440 LEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDK 504
            |.||.|:.|.|..|...:|:|..                    :|::||||.|::..:..::|.:
Human   234 LRELVLAGNRLAYLQPALFSGLA--------------------ELRELDLSRNALRAIKANVFVQ 278

  Fly   505 MPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDL-----DQISGMLFFKNSELDVIRLNDN 564
            :|.|..|.|..|.|..:.|.:||.||.||.:|||.|.:     |...|:|     .|.|:||:.|
Human   279 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-----GLRVLRLSHN 338

  Fly   565 PRLSQLP-TDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTG 628
            ...|..| |...|.:..|     |.:.:..|..|..::|..:..|..|.|..|.:..:....|.|
Human   339 AIASLRPRTFKDLHFLEE-----LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 398

  Fly   629 LHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTL 693
            |..:..::||.|.:..:.:.:|...|:|..|.|.|:.:.|:....|..|..||.|.:.|
Human   399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKD------ 457

  Fly   694 LSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPD--FQEF--IS 754
                                   |.:..|..:.:.....|..||:|:|.|...|.  ||..  :.
Human   458 -----------------------NGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 499

  Fly   755 YVTLQMQMTPKRLPVLANLEDDATIVQLETLAQAGWSSLAH 795
            |:.|....       ||.|..||    |..|.:|.|..::|
Human   500 YLLLSRNR-------LAELPADA----LGPLQRAFWLDVSH 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR	341..758	CDD:443914	111/426 (26%)
		leucine-rich repeat	343..366	CDD:275380	6/22 (27%)
		leucine-rich repeat	367..391	CDD:275380	4/23 (17%)
		leucine-rich repeat	393..415	CDD:275380	7/21 (33%)
		leucine-rich repeat	416..439	CDD:275380	9/22 (41%)
		leucine-rich repeat	440..483	CDD:275380	9/42 (21%)
		leucine-rich repeat	463..481	CDD:275380	0/17 (0%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		leucine-rich repeat	508..531	CDD:275380	9/22 (41%)
		leucine-rich repeat	532..569	CDD:275380	14/41 (34%)
		leucine-rich repeat	556..583	CDD:275380	10/27 (37%)
		leucine-rich repeat	570..607	CDD:275380	8/37 (22%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		leucine-rich repeat	632..655	CDD:275380	4/22 (18%)
		leucine-rich repeat	656..674	CDD:275380	5/17 (29%)
		leucine-rich repeat	733..745	CDD:275378	6/11 (55%)
IGFALS	NP_001139478.1	LRRNT	78..116	CDD:214470	11/61 (18%)
		leucine-rich repeat	95..113	CDD:275380	6/41 (15%)
		leucine-rich repeat	114..137	CDD:275380	9/32 (28%)
		LRR	132..574	CDD:443914	124/469 (26%)
		leucine-rich repeat	138..161	CDD:275380	6/22 (27%)
		leucine-rich repeat	162..185	CDD:275380	4/23 (17%)
		leucine-rich repeat	186..209	CDD:275380	7/22 (32%)
		leucine-rich repeat	210..233	CDD:275380	9/22 (41%)
		leucine-rich repeat	234..257	CDD:275380	9/42 (21%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		leucine-rich repeat	282..305	CDD:275380	9/22 (41%)
		leucine-rich repeat	306..324	CDD:275380	7/17 (41%)
		leucine-rich repeat	354..377	CDD:275380	5/27 (19%)
		leucine-rich repeat	378..401	CDD:275380	7/22 (32%)
		leucine-rich repeat	402..423	CDD:275380	4/20 (20%)
		leucine-rich repeat	426..447	CDD:275380	6/20 (30%)
		leucine-rich repeat	450..473	CDD:275380	6/51 (12%)
		leucine-rich repeat	474..497	CDD:275380	9/22 (41%)
		leucine-rich repeat	498..519	CDD:275380	8/31 (26%)
		leucine-rich repeat	522..543	CDD:275380	3/8 (38%)
		leucine-rich repeat	546..565	CDD:275380
		LRRCT	574..618	CDD:214507