DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gp150 and haf

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001356954.1	Gene:	haf / 33339	FlyBaseID:	FBgn0261509	Length:	1347	Species:	Drosophila melanogaster

Alignment Length:	417	Identity:	106/417 - (25%)
Similarity:	172/417 - (41%)	Gaps:	91/417 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 QVVFSEDVP-CPRFCQCARNVNSYLVATCSRLDMGIQKFGSDITDLVVTNVGPKYPILMGPN--- 309
            |..:..||| ....|.||.|:...|...|.::|.      |.:...:.|:...|...|:..|
  Fly    34 QCPWQRDVPDLQTSCICAYNLGRELSVQCDQVDF------SQLLAAMNTHARLKPVDLLYVNNST 92

  Fly   310 -------FFQNLGLKNVASIKIANCTLEYLHAEAFHG----------------------LNELYA 345
                   .|.||.|.|   :::::|.::.:...||.|                      |..|..
  Fly    93 ISELPDAVFSNLSLHN---LQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGK 154

  Fly   346 VNLTDVG---LAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNL----- 402
            :||.|:.   |:.|..|.|||..||..|.::.|:::        |.|::...|:.|..||
  Fly   155 LNLLDLSKNQLSHIPDDAFVGLTKLSTLKLNDNNVT--------LASNAFRGLEQSLKNLNLKGT 211

  Fly   403 -MELNPKAFSHLSNVVYINLSQNSLKKLPE----KAFEKVTLLEELDLSYNSLTELPRDIFNGT- 461
             ....|::...|.::.:::||||.:|:||.    :.|:.:..|..|:|..|.:..:....|.|.
  Fly   212 KQRKVPESIRGLKSLAFLDLSQNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVR 276

  Fly   462 -TLSILHLKYNTFN----GDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKI 521
             |||.|.|..|...    |.:| ..|:|:.||:.||.:..:..:.|...||:|.|.|.||.:..:
  Fly   277 KTLSSLSLLNNLLAEFPIGAVH-SLKELRVLDIGFNLLTSLPEAAFRGNPGITLLALDGNPLSSV 340

  Fly   522 QPDSF----LTLKNLR------HIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLP----T 572
            ...:|    .||:.|.      |.|..:..:.:     :.:|.:|.|.....||:....|    .
  Fly   341 PEGAFAHLNATLRGLSLGGRFLHCDCKLRWVAE-----WIRNGDLQVTSRERNPQFCGTPPRFRD 400

  Fly   573 DGFLSYSGEFTVYYLDISNCAI-GPLG 598
            .||.|...| .:...||::.|: ||:|
  Fly   401 RGFYSIQPE-ELSCPDIADAALRGPVG 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	20/84 (24%)
		leucine-rich repeat	343..366	CDD:275380	10/25 (40%)
		leucine-rich repeat	367..391	CDD:275380	5/23 (22%)
		LRR_RI	<374..619	CDD:238064	67/256 (26%)
		LRR_8	390..450	CDD:290566	18/69 (26%)
		leucine-rich repeat	393..415	CDD:275380	6/27 (22%)
		leucine-rich repeat	416..439	CDD:275380	8/26 (31%)
		leucine-rich repeat	440..483	CDD:275380	14/48 (29%)
		leucine-rich repeat	463..481	CDD:275380	7/21 (33%)
		LRR_8	484..542	CDD:290566	19/67 (28%)
		leucine-rich repeat	484..507	CDD:275380	6/22 (27%)
		leucine-rich repeat	508..531	CDD:275380	8/26 (31%)
		leucine-rich repeat	532..569	CDD:275380	8/42 (19%)
		leucine-rich repeat	556..583	CDD:275380	9/30 (30%)
		leucine-rich repeat	570..607	CDD:275380	11/34 (32%)
		LRR_RI	<586..745	CDD:238064	6/14 (43%)
		LRR_8	606..666	CDD:290566
		leucine-rich repeat	608..631	CDD:275380
		leucine-rich repeat	632..655	CDD:275380
		leucine-rich repeat	656..674	CDD:275380
		leucine-rich repeat	733..745	CDD:275378
haf	NP_001356954.1	LRR	<52..>252	CDD:227223	49/216 (23%)
		leucine-rich repeat	86..105	CDD:275380	3/18 (17%)
		leucine-rich repeat	106..129	CDD:275380	6/25 (24%)
		LRR_8	131..189	CDD:338972	15/57 (26%)
		leucine-rich repeat	131..154	CDD:275380	2/22 (9%)
		leucine-rich repeat	155..178	CDD:275380	9/22 (41%)
		leucine-rich repeat	179..202	CDD:275380	6/30 (20%)
		leucine-rich repeat	203..225	CDD:275380	4/21 (19%)
		leucine-rich repeat	226..253	CDD:275380	8/26 (31%)
		LRR_8	254..337	CDD:338972	28/83 (34%)
		leucine-rich repeat	254..302	CDD:275380	14/48 (29%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		PCC	332..>413	CDD:188093	19/86 (22%)
		PRK10927	<1061..>1097	CDD:236797
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910