Protein Alignment Gp150 and LRRTM2

DIOPT Version :10

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_056379.1
• Gene: LRRTM2 / 26045
• HGNCID: 19409
• Length: 516
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 99/431 - (22%)
• Similarity: 162/431 - (37%)
• Gaps: 137/431 - (31%)

  Fly   301 KYPI---LMGPNFFQNLGLKNVASIKIA---NCTLE----YLHAEAFHGLNELYAVNLTDVGLAI 355
            |:|:   ::...:..::.||.:.::.:|   .|..|    |..::.||.:     .|.||.|
Human     6 KWPLGAPMLAAIYAMSMVLKMLPALGMACPPKCRCEKLLFYCDSQGFHSV-----PNATDKG--- 62

  Fly   356 INPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 420
                 .:|                               |....|::.||....|:..|.:.:::
Human    63 -----SLG-------------------------------LSLRHNHITELERDQFASFSQLTWLH 91

  Fly   421 LSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQ 485
            |..|.:..:.|.||:.:..|:||.||.|.:..||    |.|...::                :||
Human    92 LDHNQISTVKEDAFQGLYKLKELILSSNKIFYLP----NTTFTQLI----------------NLQ 136

  Fly   486 QLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLF 550
            .||||||.:..:|..:|..:..|..|:|:.|.::.|....|...::|..:|||.|
Human   137 NLDLSFNQLSSLHPELFYGLRKLQTLHLRSNSLRTIPVRLFWDCRSLEFLDLSTN---------- 191

  Fly   551 FKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAW 615
                           ||..|..:||   :|...:..|.:.:..:..:....|..:..|.||.|.|
Human   192 ---------------RLRSLARNGF---AGLIKLRELHLEHNQLTKINFAHFLRLSSLHTLFLQW 238

  Fly   616 NNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQL 680
            |.|                    :||...|:    ...|.|.||.|.||.|..:.:.:|..:..|
Human   239 NKI--------------------SNLTCGME----WTWGTLEKLDLTGNEIKAIDLTVFETMPNL 279

  Fly   681 RCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNA---SGNL 718
            :.|.:::.:|.:|.|        ||.:||||...   ||||
Human   280 KILLMDNNKLNSLDS--------KILNSLRSLTTVGLSGNL 312

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR	341..758	CDD:443914	89/381 (23%)
		leucine-rich repeat	343..366	CDD:275380	5/22 (23%)
		leucine-rich repeat	367..391	CDD:275380	0/23 (0%)
		leucine-rich repeat	393..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..483	CDD:275380	10/42 (24%)
		leucine-rich repeat	463..481	CDD:275380	0/17 (0%)
		leucine-rich repeat	484..507	CDD:275380	10/22 (45%)
		leucine-rich repeat	508..531	CDD:275380	6/22 (27%)
		leucine-rich repeat	532..569	CDD:275380	7/36 (19%)
		leucine-rich repeat	556..583	CDD:275380	6/26 (23%)
		leucine-rich repeat	570..607	CDD:275380	6/36 (17%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		leucine-rich repeat	632..655	CDD:275380	3/22 (14%)
		leucine-rich repeat	656..674	CDD:275380	7/17 (41%)
		leucine-rich repeat	733..745	CDD:275378
LRRTM2	NP_056379.1	LRR	56..>312	CDD:443914	87/374 (23%)
		LRR 1	63..83		6/50 (12%)
		leucine-rich repeat	66..86	CDD:275380	5/19 (26%)
		LRR 2	86..107		5/20 (25%)
		leucine-rich repeat	87..110	CDD:275380	5/22 (23%)
		LRR 3	110..131		10/24 (42%)
		leucine-rich repeat	111..134	CDD:275380	10/42 (24%)
		LRR 4	134..155		10/20 (50%)
		leucine-rich repeat	135..158	CDD:275380	10/22 (45%)
		LRR 5	158..179		6/20 (30%)
		leucine-rich repeat	159..182	CDD:275380	6/22 (27%)
		LRR 6	182..203		10/48 (21%)
		leucine-rich repeat	183..206	CDD:275380	11/50 (22%)
		LRR 7	206..227		2/20 (10%)
		leucine-rich repeat	207..230	CDD:275380	2/22 (9%)
		LRR 8	230..251		10/44 (23%)
		leucine-rich repeat	231..254	CDD:275380	10/46 (22%)
		LRR 9	254..275		8/20 (40%)
		leucine-rich repeat	255..278	CDD:275380	8/22 (36%)
		LRR 10	278..299		7/28 (25%)
		leucine-rich repeat	279..300	CDD:275380	7/28 (25%)
		PCC	284..>351	CDD:188093	13/37 (35%)
		Involved in DLG4-binding. /evidence=ECO:0000250	513..516