DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gp150 and TSKU

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_001305406.1	Gene:	TSKU / 25987	HGNCID:	28850	Length:	367	Species:	Homo sapiens

Alignment Length:	348	Identity:	88/348 - (25%)
Similarity:	141/348 - (40%)	Gaps:	96/348 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   370 LTISGNDL-----SVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKL 429
            |.:|.|.|     ||::...|    :::..||.|.|.|..::|.|||.|..:..::||.|.|..|
Human    77 LDLSSNRLEMVNESVLAGPGY----TTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTAL 137

  Fly   430 PEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLS---ILH--LKYNTFNGDLHFGTK------D 483
            |.::|.. :.|.:::||:|.|.|:....|  ||.|   .||  |.:|..:..:...|:      .
Human   138 PAESFTS-SPLSDVNLSHNQLREVSVSAF--TTHSQGRALHVDLSHNLIHRLVPHPTRAGLPAPT 199

  Fly   484 LQQLDLSFNSIVQVHHSMFDKMPGLTN-----LNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLD 543
            :|.|:|::|.:    |:    :|.|.:     |:|.||.:..|.|.:|..|..|.|:.|:
Human   200 IQSLNLAWNRL----HA----VPNLRDLPLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLA----- 251

  Fly   544 QISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHL 608
                                  .|.:||                     .:.|.|   |..:|.|
Human   252 ----------------------SLQRLP---------------------ELAPSG---FRELPGL 270

  Fly   609 TTLKLAWN-NINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVR 672
            ..|.|:.| .:|....|:|:||..|.:||||...:..:.:.:.:....|..:|:..:...|..||
Human   271 QVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQSVSVGQDVRCRRLVR 335

  Fly   673 L--------FLPLHQLRCLDVND 687
            .        ..|...|.|:|..|
Human   336 EGTYPRRPGSSPKVALHCVDTRD 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	3/6 (50%)
		leucine-rich repeat	343..366	CDD:275380
		leucine-rich repeat	367..391	CDD:275380	7/25 (28%)
		LRR_RI	<374..619	CDD:238064	66/266 (25%)
		LRR_8	390..450	CDD:290566	21/59 (36%)
		leucine-rich repeat	393..415	CDD:275380	10/21 (48%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..483	CDD:275380	15/53 (28%)
		leucine-rich repeat	463..481	CDD:275380	5/22 (23%)
		LRR_8	484..542	CDD:290566	18/62 (29%)
		leucine-rich repeat	484..507	CDD:275380	5/22 (23%)
		leucine-rich repeat	508..531	CDD:275380	9/27 (33%)
		leucine-rich repeat	532..569	CDD:275380	4/36 (11%)
		leucine-rich repeat	556..583	CDD:275380	3/26 (12%)
		leucine-rich repeat	570..607	CDD:275380	5/36 (14%)
		LRR_RI	<586..745	CDD:238064	28/111 (25%)
		LRR_8	606..666	CDD:290566	17/60 (28%)
		leucine-rich repeat	608..631	CDD:275380	9/23 (39%)
		leucine-rich repeat	632..655	CDD:275380	5/22 (23%)
		leucine-rich repeat	656..674	CDD:275380	5/25 (20%)
		leucine-rich repeat	733..745	CDD:275378
TSKU	NP_001305406.1	LRR_RI	52..305	CDD:238064	78/293 (27%)
		leucine-rich repeat	76..99	CDD:275380	7/25 (28%)
		leucine-rich repeat	100..123	CDD:275380	10/22 (45%)
		LRR_8	103..157	CDD:290566	21/54 (39%)
		leucine-rich repeat	124..145	CDD:275380	7/21 (33%)
		leucine-rich repeat	147..170	CDD:275380	9/24 (38%)
		leucine-rich repeat	171..197	CDD:275380	5/25 (20%)
		leucine-rich repeat	200..219	CDD:275380	7/26 (27%)
		LRR_8	221..279	CDD:290566	21/108 (19%)
		leucine-rich repeat	221..244	CDD:275380	8/22 (36%)
		leucine-rich repeat	245..269	CDD:275380	9/74 (12%)
		LRR_8	268..321	CDD:290566	16/52 (31%)
		leucine-rich repeat	270..294	CDD:275380	9/23 (39%)
		leucine-rich repeat	295..316	CDD:275380	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010