DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gp150 and cyr1

DIOPT Version :9

Sequence 1:	NP_477049.2	Gene:	Gp150 / 37549	FlyBaseID:	FBgn0013272	Length:	1076	Species:	Drosophila melanogaster
Sequence 2:	NP_596159.1	Gene:	cyr1 / 2540810	PomBaseID:	SPBC19C7.03	Length:	1692	Species:	Schizosaccharomyces pombe

Alignment Length:	1045	Identity:	230/1045 - (22%)
Similarity:	394/1045 - (37%)	Gaps:	290/1045 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ITGPHLLSNPHDI----------SGLPIYRKMSRQSTCRLVLLLAFTLALIHASHSNTVGPKIHF 59
            ||..:|.::.|:.          ||.|:....:..||              .|..|.:|  ..||
pombe    47 ITEANLCNDSHEALSPCTQPVGNSGRPVEAFKTYPST--------------PAVPSKSV--LFHF 95

  Fly    60 IHDDLTENELNSGEEVSPTESLPKISTPKVKDLPVETTTR--SPTKKTTSSGTEKSLSEEA-WND 121
            ...|...:..::|...|.|....:.|:.| .::|.:|.:.  .|.|:..||..  ::|:|| ...
pombe    96 YEPDENFSLSDTGRTKSDTALAARESSEK-SEVPRDTRSAGIKPYKENNSSNC--AISKEAGLRR 157

  Fly   122 LMEAAKHSQALADDPHFNKMLN---TTVAAGEKNSTDTDDSEYYDYDDDYNYFDEETVTISPSPK 183
            |::..:.|        |:|.||   |.:...|..|.|:|..|:                     :
pombe   158 LIDKDRES--------FDKNLNQSFTNLTFPEPISDDSDSVEF---------------------Q 193

  Fly   184 KAKSNPKLQPIVDATITKSKSKSNDQKTKESANDI-DSD---SQYD--------YDEGLDDDD-- 234
            :...|......::.:|.:....|:|.....||..| |.|   ..||        |...|.||.
pombe   194 RDSLNNNWPASLEGSIHELPRNSDDDGIPASAAHILDLDYHRDSYDSPWKKFLPYPSILSDDSWK 258

  Fly   235 DEDDAADDLLTD--DEQV---------------------VFSED-----VPCP------------ 259
            ..:.....|.|:  .:||                     |:.:|     ..||
pombe   259 APESWGTSLPTEAIPKQVFTTRFFARPSLGNRKKEFFLRVYRDDRTSVSFICPIGIQTHEVIKLL 323

  Fly   260 -RFCQCARNVNSYLV--------------ATCSRLDMGIQKFGSDITDLVVTNVGPKYPIL---- 305
             |......:.|.||:              ..|...:..:..||..:|.....|....|.:.
pombe   324 ARLFFLPSSANFYLLLIQFNTERILLPHEQPCIIFERLLSLFGCKVTSDEEINEEDNYSVARLVF 388

  Fly   306 ----MGPNFFQNLGLKNV-ASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGN- 364
                :|.:..:....|.: |::.|:...||.:..:.:...:||.::|::. .|::..|..|:..
pombe   389 TTMDIGADVLRKFSEKKITANLDISRSNLEVIPVKIYPYAHELISLNVSH-NLSLDLPLDFMERC 452

  Fly   365 KKLRMLTIS-------GNDLSVMSSIHYL-LKSSSIEELD------FSRNNLMELN--------- 406
            .||:.|.||       |..::.:..:..| :..:.|.|||      .|||:|.|||
pombe   453 VKLKRLDISNNLRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANNKLFFL 517

  Fly   407 PKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYN 471
            |.:..:|.|:.|::||.|:....| ....:::.||.|:.|:|.|:::...|.:...|..|:|::|
pombe   518 PHSTRYLVNLTYLDLSYNNFVTFP-LIITELSQLETLNFSHNLLSQISSKIGSLVKLKHLYLQFN 581

  Fly   472 TFNGDL--HFG-TKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKN-- 531
            ..:..|  ..| .|:|:.:|||:|:|..:  :...:.|.|.::|:..|.:      ||....|
pombe   582 DLSNRLPQEIGLLKNLETIDLSYNAITNI--ASLSECPKLNSINVACNLL------SFYEYSNPS 638

  Fly   532 LRHIDLSINDLDQI------SGMLFFKNSELDVIRLND-------NPRLSQLPTDGFLSYSGEFT 583
            ...||.|...|..|      |.:::|..|...:|.|.|       |....::..:.|.|.|...:
pombe   639 ATFIDFSFCPLTTIDPAFSYSNLVYFDISHAKLIGLKDSVIETLVNVETVKVNYNHFTSISDAIS 703

  Fly   584 ----VYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITR 644
                :.||..:||.:..:... ...:.||..|.|..|||...|.|::. :..|..::||:|::.:
pombe   704 AMQNLKYLSCTNCEMSYVSPN-LGKLKHLVHLDLHANNIKIFPEEVWQ-VSSLKVVNLSSNILEK 766

  Fly   645 MDDLIFMDNGELTKL--------SLAGNPISRLSVRLFL--PLHQLRCLD---VNDCELTTLLSD 696
            : .|....:.:||:.        :|:|||:|.||.:.|:  .:.:|..:|   .||| .|.|
pombe   767 I-KLPVATSKKLTRTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDC-FTAL--- 826

  Fly   697 RDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEFISYVTLQMQ 761
                   :.|..|:..|.|.|.:.:|.|:..::|.:|:.|.::.|.
pombe   827 -------EYFKCLKVLNLSYNYLTEIPSKFFQNFSDLKHLFVSGNE------------------- 865

  Fly   762 MTPKRLPVLANLEDDATI-VQLETLAQAGWSSLAHEVCKHAEGSDLLDEKKADSAEAKL------ 819
                    ||||...:|. |.||||              :|.|:.|....|.::....|
pombe   866 --------LANLSISSTAQVLLETL--------------YANGNRLSSFPKNEALSKSLRFLDIS 908

  Fly   820 ---------EKRLKESVKKLNEDEAKLL--------SVLDKSVLDKSRLSSMQKIMKGSVNTETA 867
                     ||..|:|:.||.:.|...|        |..:.:...||.|.:::.:....:||:.:
pombe   909 TNNLQNLAVEKAEKKSLTKLPQLEYLNLSGNTWFRFSEHEDTNFTKSYLKNLKFLSIMDLNTKFS 973

  Fly   868 KPEED 872
            ....|
pombe   974 NAPSD 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	17/68 (25%)
		leucine-rich repeat	343..366	CDD:275380	5/23 (22%)
		leucine-rich repeat	367..391	CDD:275380	6/31 (19%)
		LRR_RI	<374..619	CDD:238064	73/282 (26%)
		LRR_8	390..450	CDD:290566	24/74 (32%)
		leucine-rich repeat	393..415	CDD:275380	12/36 (33%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..483	CDD:275380	13/45 (29%)
		leucine-rich repeat	463..481	CDD:275380	6/20 (30%)
		LRR_8	484..542	CDD:290566	16/59 (27%)
		leucine-rich repeat	484..507	CDD:275380	6/22 (27%)
		leucine-rich repeat	508..531	CDD:275380	5/22 (23%)
		leucine-rich repeat	532..569	CDD:275380	12/49 (24%)
		leucine-rich repeat	556..583	CDD:275380	7/33 (21%)
		leucine-rich repeat	570..607	CDD:275380	7/40 (18%)
		LRR_RI	<586..745	CDD:238064	46/171 (27%)
		LRR_8	606..666	CDD:290566	19/67 (28%)
		leucine-rich repeat	608..631	CDD:275380	8/22 (36%)
		leucine-rich repeat	632..655	CDD:275380	5/22 (23%)
		leucine-rich repeat	656..674	CDD:275380	9/25 (36%)
		leucine-rich repeat	733..745	CDD:275378	3/11 (27%)
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025	13/73 (18%)
		UBQ	292..387	CDD:294102	14/94 (15%)
		leucine-rich repeat	409..430	CDD:275380	3/20 (15%)
		leucine-rich repeat	431..454	CDD:275380	5/23 (22%)
		LRR_RI	<441..616	CDD:238064	48/177 (27%)
		leucine-rich repeat	455..477	CDD:275380	5/21 (24%)
		LRR_8	476..537	CDD:290566	19/60 (32%)
		leucine-rich repeat	478..503	CDD:275380	7/24 (29%)
		leucine-rich repeat	504..526	CDD:275380	6/21 (29%)
		leucine-rich repeat	527..549	CDD:275380	5/22 (23%)
		LRR_8	548..607	CDD:290566	19/58 (33%)
		leucine-rich repeat	550..572	CDD:275380	7/21 (33%)
		leucine-rich repeat	573..596	CDD:275380	6/22 (27%)
		leucine-rich repeat	597..618	CDD:275380	6/22 (27%)
		leucine-rich repeat	661..684	CDD:275380	5/22 (23%)
		leucine-rich repeat	685..707	CDD:275380	3/21 (14%)
		leucine-rich repeat	708..730	CDD:275380	4/22 (18%)
		LRR_RI	<724..941	CDD:238064	65/271 (24%)
		leucine-rich repeat	754..783	CDD:275380	7/29 (24%)
		leucine-rich repeat	784..807	CDD:275380	8/22 (36%)
		leucine-rich repeat	808..831	CDD:275380	8/33 (24%)
		LRR_8	832..889	CDD:290566	22/97 (23%)
		leucine-rich repeat	832..855	CDD:275380	7/22 (32%)
		leucine-rich repeat	856..877	CDD:275380	8/47 (17%)
		leucine-rich repeat	879..901	CDD:275380	8/35 (23%)
		leucine-rich repeat	902..930	CDD:275380	7/27 (26%)
		PP2C	1032..1268	CDD:278884
		CYCc	1300..1488	CDD:214485
		Nucleotidyl_cyc_III	1323..1519	CDD:299850
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960