Protein Alignment Gp150 and lron-5

DIOPT Version :9

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_497943.2
• Gene: lron-5 / 184307
• WormBaseID: WBGene00008656
• Length: 656
• Species: Caenorhabditis elegans
• Alignment Length: 703
• Identity: 154/703 - (21%)
• Similarity: 257/703 - (36%)
• Gaps: 204/703 - (29%)

  Fly   262 CQC-------ARNVNSYLVATCSRLDMGIQKFGSDITDLVVTNVGPKYPILMGPNFFQNLGLKNV 319
            |.|       ..|..|.|:.|.|.|        ..|..|.:.::....|    |:|   |...|:
 Worm    24 CDCDFISHTVVCNRPSLLIRTVSML--------PTIRQLHLNSLNLPQP----PHF---LFHPNL 73

  Fly   320 ASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIH 384
            ..::::.|.:..:....|..|..|..::|::..|..:.|......|.||:|.:|.|.||.:..:.
 Worm    74 RVLRMSRCGMHEIPGSTFLPLPGLEVIDLSNNHLETLPPTVLRSLKFLRVLILSNNRLSNLDQLT 138

  Fly   385 YLLKSSSI-EELDFSRNNL-----MELNP---KAFSHLSNVVYINLSQNSLKKLPEKAFE----- 435
            ::|....: |:||.|.|.:     |.:.|   :.|...:.:..:|.:....||||.|...
 Worm   139 WILAPGVVLEQLDLSGNPIAIATSMTVFPPVRQLFLSDTRMESVNETAIMFKKLPGKCDRDVCRH 203

  Fly   436 ------KVTLLEELDLSYNSLTELPR---DIFNGTT-------------------------LSIL 466
                  .|:::..:|.|.|...|:..   |:|:..|                         |:|.
 Worm   204 IPIHNLNVSIITTIDFSSNRDLEIDSGALDVFSNATYVDLSNTRLPVGFEEWLERKSRVKSLNIS 268

  Fly   467 HLKYNTFNGDLHFGT-----KDLQQLDLS------------------------FNSI-------- 494
            |.:.     .||..|     :.|..||:|                        .:|:
 Worm   269 HCQL-----PLHEDTWTACGQFLHSLDISGIGAKRLRFSRFCPIRSVFARDNLISSVYIDAVSME 328

  Fly   495 -VQVHHSMFDKMP---------GLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGML 549
             :.:..:||.:.|         .|..|.|..|.:..:.|.:..:..||:|.|:|.|.|.:|....
 Worm   329 SLHLERNMFSEFPIPPPGVELTELHTLGLSHNLMTSLPPHALQSYPNLQHFDVSSNQLSEIDPQA 393

  Fly   550 FFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLA 614
            |              |.:..    |.:|         ||:|:..:..|.|   ..:|.|..|.|:
 Worm   394 F--------------PSIGL----GLIS---------LDLSSNQLSSLPH---PILPSLLLLDLS 428

  Fly   615 WNNINHLPREIFTGLHKLIDLDLSNN--LITR---MDDLIFMDN-GELTKLSLAGNPISRLSVRL 673
            :|.|:||....||||..|..|.:::|  |.:|   .|...:.|: .|||  ||....||...:..
 Worm   429 FNTISHLDPHFFTGLPMLQQLRIASNPTLFSRCPNRDSPCWSDHLDELT--SLVDLDISNSGLEF 491

  Fly   674 FLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDS------LRSFNASGNLIKKISSEDVKSFKN 732
            .|....||.|.      :.:|...::    :|.||      ||:.:...|.::..|  :....::
 Worm   492 SLHWRHLRTLK------SLILRGNEI----RIIDSKSLPENLRTLDLGENRVQFTS--NFSKLEH 544

  Fly   733 LRSLDITNNPLKCTPDFQEFISYVTLQMQMTP-------------KRLPVLANLED--DAT---- 778
            ||.|.:..|||:|.....:.:.::..|.|::.             ..||.||:::.  |.|
 Worm   545 LRDLRVDQNPLRCDCSLYDIVPHLLNQSQISDPLLYYCFSGSWQYPLLPYLASVKPCVDTTRNFY 609

  Fly   779 IVQLETLAQAGWSSLAHEVCKHAEGSDLLDEKKADSAEAKLEK-RLKESVKKL 830
            .:.:.|..      :|..:.....|..|:..|.||.|....:: .|.||..:|
 Worm   610 SILITTFI------IAFAIVAGLIGGFLVYRKYADRANFVYKRISLMESPVRL 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR_8	317..377	CDD:290566	14/59 (24%)
		leucine-rich repeat	343..366	CDD:275380	4/22 (18%)
		leucine-rich repeat	367..391	CDD:275380	8/23 (35%)
		LRR_RI	<374..619	CDD:238064	67/339 (20%)
		LRR_8	390..450	CDD:290566	18/79 (23%)
		leucine-rich repeat	393..415	CDD:275380	8/29 (28%)
		leucine-rich repeat	416..439	CDD:275380	7/33 (21%)
		leucine-rich repeat	440..483	CDD:275380	13/75 (17%)
		leucine-rich repeat	463..481	CDD:275380	5/17 (29%)
		LRR_8	484..542	CDD:290566	19/99 (19%)
		leucine-rich repeat	484..507	CDD:275380	8/64 (13%)
		leucine-rich repeat	508..531	CDD:275380	5/22 (23%)
		leucine-rich repeat	532..569	CDD:275380	9/36 (25%)
		leucine-rich repeat	556..583	CDD:275380	3/26 (12%)
		leucine-rich repeat	570..607	CDD:275380	7/36 (19%)
		LRR_RI	<586..745	CDD:238064	49/170 (29%)
		LRR_8	606..666	CDD:290566	24/65 (37%)
		leucine-rich repeat	608..631	CDD:275380	11/22 (50%)
		leucine-rich repeat	632..655	CDD:275380	7/28 (25%)
		leucine-rich repeat	656..674	CDD:275380	6/17 (35%)
		leucine-rich repeat	733..745	CDD:275378	6/11 (55%)
lron-5	NP_497943.2	leucine-rich repeat	51..72	CDD:275380	6/27 (22%)
		LRR_8	72..131	CDD:338972	14/58 (24%)
		leucine-rich repeat	73..96	CDD:275380	3/22 (14%)
		LRR	<92..>272	CDD:227223	39/179 (22%)
		leucine-rich repeat	97..120	CDD:275380	4/22 (18%)
		leucine-rich repeat	121..146	CDD:275380	8/24 (33%)
		leucine-rich repeat	147..168	CDD:275380	6/20 (30%)
		leucine-rich repeat	169..208	CDD:275380	7/38 (18%)
		leucine-rich repeat	209..237	CDD:275380	7/27 (26%)
		leucine-rich repeat	238..284	CDD:275380	7/50 (14%)
		leucine-rich repeat	327..351	CDD:275380	3/23 (13%)
		internalin_A	345..>576	CDD:380193	69/274 (25%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..391	CDD:275380	7/14 (50%)
		leucine-rich repeat	401..445	CDD:275380	18/55 (33%)
		leucine-rich repeat	446..478	CDD:275380	10/33 (30%)
		leucine-rich repeat	479..500	CDD:275380	5/20 (25%)
		leucine-rich repeat	501..522	CDD:275380	5/30 (17%)
		leucine-rich repeat	523..544	CDD:275380	4/22 (18%)
		LRRCT	553..601	CDD:214507	10/47 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010