Protein Alignment Gp150 and sym-1

DIOPT Version :10

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_510426.1
• Gene: sym-1 / 181555
• WormBaseID: WBGene00006366
• Length: 680
• Species: Caenorhabditis elegans
• Alignment Length: 862
• Identity: 179/862 - (20%)
• Similarity: 314/862 - (36%)
• Gaps: 258/862 - (29%)

  Fly   258 CPRF------CQCARNVNSYLVATCSRLD--MGIQKFGS----DITDLVVTNVGPKYPILMGPNF 310
            ||:.      |.|...|...:: .||..|  ..::|..:    ::.:|.:.|..   .|.:||..
 Worm    19 CPKLFQNQTACSCDSTVEGPVI-KCSGHDGLRMVEKLSTTTTMEVRELALENAD---IIEVGPKA 79

  Fly   311 FQNLGLKNVASIKIANCTLEYLHAEAFHGL-NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISG 374
            |:.|.:|.:.   ::|..:|.:|..||.|| |.:..::|::..|..:......|   ||:|.|
 Worm    80 FKTLRIKKLI---LSNNRIEKIHDHAFTGLENVMQELSLSENNLKEVPTSALAG---LRVLNI-- 136

  Fly   375 NDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTL 439
                                |....|.:..:..|||.::::::.:||..|.:..:....|..|.:
 Worm   137 --------------------LSLKCNKIENITTKAFVNMTSLIDVNLGCNQICSMAADTFANVKM 181

  Fly   440 -LEELDLSYNSLTELP-RDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMF 502
             |:.|.|..|.:||.| :.:.|...|..||:|||..|.        ::|.|             |
 Worm   182 SLQNLILDNNCMTEFPSKAVRNMNNLIALHIKYNKINA--------IRQND-------------F 225

  Fly   503 DKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRL 567
            ..:..|:.|:|.||.|.:|:..:.....||.::.|:.|:|..:                 ||..|
 Worm   226 VNLTSLSMLSLNGNNISEIKGGALQNTPNLHYLYLNENNLQTL-----------------DNGVL 273

  Fly   568 SQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKL 632
            .|                                   ...|..|.|::||...:.:|:|.||..:
 Worm   274 EQ-----------------------------------FKQLQVLDLSFNNFTDITKEMFEGLESI 303

  Fly   633 IDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDR 697
            ..|:|.:|.|:.:....|           ||.|:    :.|:||         |:| ||.:....
 Worm   304 QHLNLDSNRISAVAPGAF-----------AGTPL----LLLWLP---------NNC-LTEVSQQT 343

  Fly   698 DLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEFISYVTLQMQM 762
            ..||.:     ||..:.|.|.|:::.........||.:||:.||.:            ::||.:.
 Worm   344 LKGAPF-----LRMVSLSNNNIREVHELSFDHLPNLHTLDLANNKI------------MSLQNKS 391

  Fly   763 T--PKRLPVLANLEDDATI-----VQLETLAQAGW-SSLAHEVCK---HAEGSDLLDEKKADSAE 816
            .  |:.|.|  .|:::..:     ..:....:|.| ::.|:.:||   .|:.:||.
 Worm   392 LSGPENLAV--RLQENPVVCVKNGFHVLNSGEAIWLTNEANTICKGEWQAQTADLC--------- 445

  Fly   817 AKLEKRLKESVKKLNEDEAKLLSVLDKSVLDKSRLSSMQKIMKGSVNTETAKPEEDADEENLNNG 881
            .|.:.|....|...||            :...:..::....:..:..||..|.|.....|.:...
 Worm   446 PKAQPRPIRPVCCSNE------------ITTTTTTTTTTTTLAPTTTTEEEKEETTETTEKVTTV 498

  Fly   882 GEDKEDDSSDYDSEEDDDDDDEDDDDDNNDDDRFEEAKKNAKA------KADANKA----FDTFV 936
            |:.|:..::....|.:||:|...|||:...::..||.....|:      ..:|:|:    .:.|.
 Worm   499 GKSKKTKATTTTEEPEDDEDVYVDDDEEGTEEEEEEVSTTEKSTTTTTTTTEASKSKKVNMERFW 563

  Fly   937 NKELKPVLKTDGIQAEEVDMSQETRDKFL------------LEKLGFDSESEESDEYTEKMIFHG 989
            ....||..|:..::     .||..:.::|            .|.:..|..:|||:|....:....
 Worm   564 RLSNKPSGKSPFLR-----HSQGNKPRYLQTTTEAPEEEDEAEYISDDGGAEESEEAETTVATTT 623

  Fly   990 ELSYDLVVPLIVVSFCLLMIVLSIARVIYVVLRKRGERYRMALLAS---------KNSFVYQKLS 1045
            .....:.||               ||:          |.|..:.||         |...|.::.|
 Worm   624 TTEPSVKVP---------------ARI----------RERQRMFASNIPWMAPRTKTDSVEEEFS 663

  Fly  1046 -EDIVKPTSKEQKEPKH 1061
             :|.|:.....:|..:|
 Worm   664 KDDEVETVETAEKPARH 680

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR	341..758	CDD:443914	89/418 (21%)
		leucine-rich repeat	343..366	CDD:275380	3/22 (14%)
		leucine-rich repeat	367..391	CDD:275380	4/23 (17%)
		leucine-rich repeat	393..415	CDD:275380	5/21 (24%)
		leucine-rich repeat	416..439	CDD:275380	5/22 (23%)
		leucine-rich repeat	440..483	CDD:275380	15/43 (35%)
		leucine-rich repeat	463..481	CDD:275380	7/17 (41%)
		leucine-rich repeat	484..507	CDD:275380	3/22 (14%)
		leucine-rich repeat	508..531	CDD:275380	7/22 (32%)
		leucine-rich repeat	532..569	CDD:275380	7/36 (19%)
		leucine-rich repeat	556..583	CDD:275380	4/26 (15%)
		leucine-rich repeat	570..607	CDD:275380	0/36 (0%)
		leucine-rich repeat	608..631	CDD:275380	9/22 (41%)
		leucine-rich repeat	632..655	CDD:275380	5/22 (23%)
		leucine-rich repeat	656..674	CDD:275380	3/17 (18%)
		leucine-rich repeat	733..745	CDD:275378	5/11 (45%)
sym-1	NP_510426.1	leucine-rich repeat	62..81	CDD:275380	5/21 (24%)
		LRR	<84..408	CDD:443914	103/468 (22%)
		leucine-rich repeat	86..108	CDD:275380	8/24 (33%)
		leucine-rich repeat	110..133	CDD:275380	4/25 (16%)
		leucine-rich repeat	134..157	CDD:275380	7/44 (16%)
		leucine-rich repeat	158..182	CDD:275380	5/23 (22%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	10/43 (23%)
		leucine-rich repeat	231..254	CDD:275380	7/22 (32%)
		leucine-rich repeat	255..278	CDD:275380	8/74 (11%)
		leucine-rich repeat	279..302	CDD:275380	9/22 (41%)
		leucine-rich repeat	303..323	CDD:275380	5/30 (17%)
		leucine-rich repeat	350..373	CDD:275380	5/22 (23%)
		leucine-rich repeat	374..394	CDD:275380	7/31 (23%)
		leucine-rich repeat	399..410	CDD:275378	2/12 (17%)