Protein Alignment Gp150 and lron-1

DIOPT Version :10

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_510424.4
• Gene: lron-1 / 181553
• WormBaseID: WBGene00008093
• Length: 607
• Species: Caenorhabditis elegans
• Alignment Length: 549
• Identity: 123/549 - (22%)
• Similarity: 206/549 - (37%)
• Gaps: 175/549 - (31%)

  Fly   251 VFSEDVPCPRF-----CQCARNVNSYLVATCSRLD-MGIQKFGSDITDLVVTNVGPKYPILMGPN 309
            |:|:   ||..     |.|          |.:|.: :.|...|....|.|:.:
 Worm    14 VYSQ---CPTLQLQEPCTC----------TSTRYEAVSINCDGGSSLDAVLES------------ 53

  Fly   310 FFQNLGLKN----VASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGN------ 364
                  |.|    :.|:.|:|..:|.:...||.|. ::..:.|.:.||...:|:||.||
 Worm    54 ------LSNSPQAIDSLTISNTPIEKMPGYAFQGF-QIKKLFLRNNGLRSFHPNTFTGNLENSLE 111

  Fly   365 --------------------KKLRMLTISGNDLSVMSSIHYLLKSS--SIEELDFSRNNLMELNP 407
                                |:|::|::..|.:..:....:|...|  |:.:||.|.|||..::|
 Worm   112 ELEIRGNYIDGIPQSGVSILKQLKILSLPDNLIEYVQDNAFLSYHSRDSLLKLDLSANNLTAIHP 176

  Fly   408 KAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNT 472
            .....|.|:..::|.:|.|.::|.:|.|.:..||:|.|..|.:..:.|
 Worm   177 TGLLGLENLSQLSLDKNLLSEIPSQALENIPSLEDLSLGVNRIHTISR----------------- 224

  Fly   473 FNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDL 537
                               ||:         .:|.|.:|:|:.|.|:.|..|||.....|.::.|
 Worm   225 -------------------NSL---------PLPNLKSLSLEVNQIRLIPSDSFSETPLLSYLYL 261

  Fly   538 SINDLDQISGMLFFKNSELDVIRLNDNPRLSQLPTDGFLSYSGEF-------------TVYYLDI 589
            ..|.|..|...:|.....|.|:.:::|..::.:..:|.||.. :|             ::..|::
 Worm   262 GNNLLTSIDASMFLHIGGLKVLSMSNNKDITSIQANGKLSVQ-QFKLCICILAFQHAPSLIRLEL 325

  Fly   590 SNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNG 654
            .:|:|..:..|:...:.|:..:.|:.|.|..:..:.|:.|.:|.:||||.|.|..:||..|....
 Worm   326 FDCSISRIEPKSLQKVQHIQVILLSRNQITRISHDTFSNLPELSELDLSGNSINAVDDFAFSQLP 390

  Fly   655 ELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLI 719
            .||.|.|:.|.:..|...:                               |:|||        :.
 Worm   391 MLTSLDLSSNRLESLPSNV-------------------------------IYDSL--------MQ 416

  Fly   720 KKISSEDVKSFKNLRSLDITNNPLKCTPD 748
            ||.|...       |.|.|.|||.:|..|
 Worm   417 KKTSPVQ-------RKLSIQNNPWRCDKD 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR	341..758	CDD:443914	102/449 (23%)
		leucine-rich repeat	343..366	CDD:275380	8/48 (17%)
		leucine-rich repeat	367..391	CDD:275380	5/25 (20%)
		leucine-rich repeat	393..415	CDD:275380	8/21 (38%)
		leucine-rich repeat	416..439	CDD:275380	6/22 (27%)
		leucine-rich repeat	440..483	CDD:275380	6/42 (14%)
		leucine-rich repeat	463..481	CDD:275380	0/17 (0%)
		leucine-rich repeat	484..507	CDD:275380	2/22 (9%)
		leucine-rich repeat	508..531	CDD:275380	9/22 (41%)
		leucine-rich repeat	532..569	CDD:275380	9/36 (25%)
		leucine-rich repeat	556..583	CDD:275380	7/39 (18%)
		leucine-rich repeat	570..607	CDD:275380	8/49 (16%)
		leucine-rich repeat	608..631	CDD:275380	5/22 (23%)
		leucine-rich repeat	632..655	CDD:275380	10/22 (45%)
		leucine-rich repeat	656..674	CDD:275380	6/17 (35%)
		leucine-rich repeat	733..745	CDD:275378	6/11 (55%)
lron-1	NP_510424.4	LRR	83..>400	CDD:443914	85/362 (23%)
		leucine-rich repeat	85..109	CDD:275380	8/23 (35%)
		leucine-rich repeat	110..133	CDD:275380	0/22 (0%)
		leucine-rich repeat	134..157	CDD:275380	4/22 (18%)
		leucine-rich repeat	161..184	CDD:275380	8/22 (36%)
		leucine-rich repeat	185..208	CDD:275380	6/22 (27%)
		leucine-rich repeat	209..231	CDD:275380	8/66 (12%)
		leucine-rich repeat	232..255	CDD:275380	9/22 (41%)
		leucine-rich repeat	256..279	CDD:275380	6/22 (27%)
		leucine-rich repeat	280..319	CDD:275380	7/39 (18%)
		leucine-rich repeat	320..343	CDD:275380	4/22 (18%)
		leucine-rich repeat	344..367	CDD:275380	5/22 (23%)
		leucine-rich repeat	368..391	CDD:275380	10/22 (45%)
		leucine-rich repeat	392..410	CDD:275380	6/48 (13%)
		leucine-rich repeat	414..435	CDD:275378	10/35 (29%)
		LRRCT	431..>472	CDD:214507	4/8 (50%)