Protein Alignment Gp150 and Igfals

DIOPT Version :10

• Sequence 1: NP_477049.2
• Gene: Gp150 / 37549
• FlyBaseID: FBgn0013272
• Length: 1076
• Species: Drosophila melanogaster
• Sequence 2: NP_001351825.1
• Gene: Igfals / 16005
• MGIID: 107973
• Length: 638
• Species: Mus musculus
• Alignment Length: 637
• Identity: 149/637 - (23%)
• Similarity: 242/637 - (37%)
• Gaps: 143/637 - (22%)

  Fly   245 TDDEQVVFSEDVPCPRFCQCA-RNVNSYLVATCSRLDMGIQKFGSDITDLVVTNVGPKYPI---- 304
            ||......:|...||..|.|: .:....|...||..::              |.:....|:
Mouse    63 TDPGASADAEGPQCPVTCTCSYDDYTDELSVFCSSRNL--------------TQLPDSIPVSTRA 113

  Fly   305 --LMGPNF-------FQN----------------------LGLKN-------------------- 318
              |.|.|.       |||                      |||:|
Mouse   114 LWLDGNNLSSIPSAAFQNLSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFR 178

  Fly   319 ----VASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDT-FVGNKKLRMLTISGNDLS 378
                :||:.:.|..|..|....|.||:.|:.:||....|.:: ||| |.|...|..|.::||.|:
Mouse   179 HTPSLASLSLGNNLLGRLEEGLFRGLSHLWDLNLGWNSLVVL-PDTVFQGLGNLHELVLAGNKLT 242

  Fly   379 VMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEEL 443
            .:... .|.....:.|||.|||.|..:....|.||..:..:.|.:|.:..:..:||..:..|..|
Mouse   243 YLQPA-LLCGLGELRELDLSRNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWL 306

  Fly   444 DLSYNSLTELPRDIFNGTT-LSILHLKYN--------TFNGDLHFGTKDLQQLDLSFNSIVQVHH 499
            |||:|.:..|..|.|.|.. |.:|.|.:|        ||. ||||    |::|.|..|.|.|:..
Mouse   307 DLSHNRVAGLLEDTFPGLLGLHVLRLAHNAITSLRPRTFK-DLHF----LEELQLGHNRIRQLGE 366

  Fly   500 SMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDN 564
            ..|:.:..|..|.|..|.|.:::..:|..|.|:..::||.|.|..:...:|
Mouse   367 KTFEGLGQLEVLTLNDNQIHEVKVGAFFGLFNVAVMNLSGNCLRSLPEHVF-------------- 417

  Fly   565 PRLSQLPTDGFLSYSGEFTVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGL 629
                          .|...::.|.:.:..:|.:....|:.:..|..|.|..|:|:.:..:...||
Mouse   418 --------------QGLGRLHSLHLEHSCLGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGL 468

  Fly   630 HKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLL 694
            .:|::|||:.|.:|.:...:|...|:|..|.|:.|.::.||..:..||.:...||::...|.|
Mouse   469 SELLELDLTANQLTHLPRQLFQGLGQLEYLLLSNNQLTMLSEDVLGPLQRAFWLDLSHNRLET-- 531

  Fly   695 SDRDLGAGYKIFDS---LRSFNASGNLIKKISSEDVKSFKNLRSLDITNNPLKCTPDFQEFISYV 756
                  ....:|.|   ||..|...|.::....:     ..|..|.:..||..|:...:....:.
Mouse   532 ------PAEGLFSSLGRLRYLNLRNNSLQTFVPQ-----PGLERLWLDANPWDCSCPLKALRDFA 585

  Fly   757 TLQMQMTPKRLPVLANLEDDATIVQLETLAQAGWSSLAHEVCKHAEGSDLLD 808
            .....:.|:.:..:...:|...:.....:..||.::::        |.||.|
Mouse   586 LQNPGVVPRFVQTVCEGDDCQPVYTYNNITCAGPANVS--------GLDLRD 629

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gp150	NP_477049.2	LRR	341..758	CDD:443914	111/429 (26%)
		leucine-rich repeat	343..366	CDD:275380	9/23 (39%)
		leucine-rich repeat	367..391	CDD:275380	6/23 (26%)
		leucine-rich repeat	393..415	CDD:275380	10/21 (48%)
		leucine-rich repeat	416..439	CDD:275380	4/22 (18%)
		leucine-rich repeat	440..483	CDD:275380	20/51 (39%)
		leucine-rich repeat	463..481	CDD:275380	10/25 (40%)
		leucine-rich repeat	484..507	CDD:275380	7/22 (32%)
		leucine-rich repeat	508..531	CDD:275380	7/22 (32%)
		leucine-rich repeat	532..569	CDD:275380	5/36 (14%)
		leucine-rich repeat	556..583	CDD:275380	1/26 (4%)
		leucine-rich repeat	570..607	CDD:275380	4/36 (11%)
		leucine-rich repeat	608..631	CDD:275380	7/22 (32%)
		leucine-rich repeat	632..655	CDD:275380	7/22 (32%)
		leucine-rich repeat	656..674	CDD:275380	6/17 (35%)
		leucine-rich repeat	733..745	CDD:275378	4/11 (36%)
Igfals	NP_001351825.1	LRR	88..457	CDD:443914	100/417 (24%)
		leucine-rich repeat	92..110	CDD:275380	4/31 (13%)
		leucine-rich repeat	114..134	CDD:275380	6/19 (32%)
		leucine-rich repeat	135..158	CDD:275380	3/22 (14%)
		leucine-rich repeat	159..182	CDD:275380	0/22 (0%)
		leucine-rich repeat	183..206	CDD:275380	8/22 (36%)
		leucine-rich repeat	207..230	CDD:275380	9/23 (39%)
		leucine-rich repeat	231..254	CDD:275380	6/23 (26%)
		leucine-rich repeat	255..278	CDD:275380	10/22 (45%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	8/23 (35%)
		leucine-rich repeat	351..374	CDD:275380	7/22 (32%)
		leucine-rich repeat	375..396	CDD:275380	6/20 (30%)
		leucine-rich repeat	423..446	CDD:275380	3/22 (14%)
		LRR_8	445..505	CDD:404697	19/59 (32%)
		leucine-rich repeat	447..470	CDD:275380	7/22 (32%)
		leucine-rich repeat	471..494	CDD:275380	7/22 (32%)
		leucine-rich repeat	495..516	CDD:275380	6/20 (30%)
		leucine-rich repeat	519..542	CDD:275380	6/30 (20%)
		LRR_8	521..571	CDD:404697	12/62 (19%)
		leucine-rich repeat	543..561	CDD:275380	4/22 (18%)
		LRRCT	570..613	CDD:214507	5/42 (12%)