DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wdp and LRRC4B

DIOPT Version :9

Sequence 1:NP_001286712.1 Gene:wdp / 37548 FlyBaseID:FBgn0034718 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_001073926.1 Gene:LRRC4B / 94030 HGNCID:25042 Length:713 Species:Homo sapiens


Alignment Length:561 Identity:126/561 - (22%)
Similarity:215/561 - (38%) Gaps:117/561 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 LTEKTFQSTVPVHSIDLSHLNLTRLSHL--LDKLPELTSADLSHNQLKDLGHLGK-----GLKRL 117
            ::|..|:..|.:..::|...||..:.:|  |.:|.||   :||.|:| ||...|.     .|::|
Human   198 ISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRLEEL---ELSGNRL-DLIRPGSFQGLTSLRKL 258

  Fly   118 NLKHNQLTS------DKLRKLPQHLQVLNLQHNNITHLPLEL-THMHQLHQLELSHNAINCSCQT 175
            .|.|.|:.:      |.|:.|.:    |||.|||:..||.:| |.:|:|.::.|:||..:|:|..
Human   259 WLMHAQVATIERNAFDDLKSLEE----LNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDV 319

  Fly   176 LEVRNWLVERIVYMEHP------VVCSYPLEFRGRSWLQLKQDEI-CKKEKYQWFDTE-ENELMM 232
            |.:..||.|.:     |      ..|..|...:||...:|.|... |    |.....| ..:|.:
Human   320 LWLSWWLKETV-----PSNTTCCARCHAPAGLKGRYIGELDQSHFTC----YAPVIVEPPTDLNV 375

  Fly   233 GDQPAAVSAEREDEEELGKDFLPIVGNPAATAKKVRSPQIPLPSDQVEGSGDLSETNMELK-LPE 296
            .:..||....|........::|    .|..|.....|.::.:   .|...|.|:.||:.:: ..:
Human   376 TEGMAAELKCRTGTSMTSVNWL----TPNGTLMTHGSYRVRI---SVLHDGTLNFTNVTVQDTGQ 433

  Fly   297 ETVAEPEAAESQLVDAAASPSVLEEHIVKDEDEDDEGSGSGGGLLIIPDPSK------------V 349
            .|.....:|.:....|..:.|.::....       .|:|||||   .|..|.            .
Human   434 YTCMVTNSAGNTTASATLNVSAVDPVAA-------GGTGSGGG---GPGGSGGVGGGSGGYTYFT 488

  Fly   350 KITSEDDIDSDGKPEESDVRPLENPENSENPDTVFSNKIGIYEGDQ--EEKKPVEEDNIVPVVMT 412
            .:|.|   ..:.:|.|..::|....:....|.|     .|::.|.:  :...|.......|...:
Human   489 TVTVE---TLETQPGEEALQPRGTEKEPPGPTT-----DGVWGGGRPGDAAGPASSSTTAPAPRS 545

  Fly   413 NLDTGLESDV-VTDGPLDSSKESEDIL-TAKIGKPKDDSSAIYYLLAVIGLIVVGLVLFVAIKRC 475
            :..|.....| :||...::.|:.:|:: |.||        .|...:|:..:..|.||.|..::: 
Human   546 SRPTEKAFTVPITDVTENALKDLDDVMKTTKI--------IIGCFVAITFMAAVMLVAFYKLRK- 601

  Fly   476 KYDSNAAARDAEAQRQTELLDMDKK---------QLGKPLHKNGHGNGQEHSPLIG-EKTKLDE- 529
               .:...:.....|..|:::::.:         .....:...|...|..|..|.. |:..|:. 
Human   602 ---QHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVASGGGVGGDSHLALPALERDHLNHH 663

  Fly   530 ---AQIVKKPYENGEAKDGAG----------QQPLLNGNGS 557
               |...|..|.:..:..|.|          .:|||..:||
Human   664 HYVAAAFKAHYSSNPSGGGCGGKGPPGLNSIHEPLLFKSGS 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdpNP_001286712.1 LRR_RI <31..176 CDD:238064 43/129 (33%)
leucine-rich repeat 47..70 CDD:275378 2/9 (22%)
LRR_8 71..124 CDD:290566 19/59 (32%)
leucine-rich repeat 73..93 CDD:275378 6/21 (29%)
leucine-rich repeat 94..112 CDD:275378 7/17 (41%)
LRR_8 112..169 CDD:290566 23/68 (34%)
leucine-rich repeat 114..134 CDD:275378 8/25 (32%)
leucine-rich repeat 136..158 CDD:275378 10/22 (45%)
leucine-rich repeat 159..171 CDD:275378 4/11 (36%)
LRRC4BNP_001073926.1 LRRNT 57..90 CDD:214470
LRR <76..297 CDD:227223 34/106 (32%)
LRR 1 87..108
leucine-rich repeat 88..111 CDD:275380
LRR 2 111..132
leucine-rich repeat 112..135 CDD:275380
LRR 3 135..156
leucine-rich repeat 136..159 CDD:275380
LRR 4 159..180
leucine-rich repeat 160..183 CDD:275380
LRR 5 183..205 2/6 (33%)
leucine-rich repeat 184..208 CDD:275380 2/9 (22%)
LRR 6 208..229 4/20 (20%)
leucine-rich repeat 209..230 CDD:275380 5/20 (25%)
LRR 7 230..251 10/24 (42%)
leucine-rich repeat 231..254 CDD:275380 10/26 (38%)
LRR 8 254..275 5/20 (25%)
leucine-rich repeat 255..278 CDD:275380 7/22 (32%)
LRR 9 278..299 10/24 (42%)
leucine-rich repeat 279..300 CDD:275380 11/24 (46%)
LRRCT 311..361 CDD:214507 14/54 (26%)
I-set 364..453 CDD:254352 17/95 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 497..551 10/58 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 694..713 5/11 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24369
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.