DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdp and RTN4R

DIOPT Version :9

Sequence 1:	NP_001286712.1	Gene:	wdp / 37548	FlyBaseID:	FBgn0034718	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_075380.1	Gene:	RTN4R / 65078	HGNCID:	18601	Length:	473	Species:	Homo sapiens

Alignment Length:	434	Identity:	92/434 - (21%)
Similarity:	136/434 - (31%)	Gaps:	173/434 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LTAWLALFLIVVANATPTPARTPTGCPADCTCSLSQHTHKPLYHLKCNSTRGLRLTEKTFQSTVP 70
            |.||: |:|.....|.|        ||..|.|     .::|.....| ..:||:        .||
Human    11 LLAWV-LWLQAWQVAAP--------CPGACVC-----YNEPKVTTSC-PQQGLQ--------AVP 52

  Fly    71 V-----------HSIDLSHL---------NLTRL---SHLLDK--------LPELTSADLSHN-Q 103
            |           |...:||:         |||.|   |::|.:        |..|...|||.| |
Human    53 VGIPAASQRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQ 117

  Fly   104 LKD---------------------LGHLGKGLKR--------------------------LNLKH 121
            |:.                     |..||.||.|                          .||.|
Human   118 LRSVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTH 182

  Fly   122 NQLTSDKLRKLPQ-------------------------------HLQVLNLQHNNITHLPLE-LT 154
            ..|..:::..:|:                               .|..|.|..||::.||.| |.
Human   183 LFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALA 247

  Fly   155 HMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPVVCSYPLEFRGRSWLQLKQDEICKKEK 219
            .:..|..|.|:.|...|.|:...:..|| ::.......|.||.|....||...:|..:
Human   248 PLRALQYLRLNDNPWVCDCRARPLWAWL-QKFRGSSSEVPCSLPQRLAGRDLKRLAAN------- 304

  Fly   220 YQWFDTEENELMMGDQPAAVSAEREDEEELG---------KDFLPIV--GNPAATAKKVRSPQIP 273
                |.:...:..|......:....|||.||         .|...::  |.||:....::. ::|
Human   305 ----DLQGCAVATGPYHPIWTGRATDEEPLGLPKCCQPDAADKASVLEPGRPASAGNALKG-RVP 364

  Fly   274 LPSDQVEGSGD----LSET-------NMELKLPEETVAEPEAAE 306
             |.|...|:|.    ::::       :.|   |..|...||.:|
Human   365 -PGDSPPGNGSGPRHINDSPFGTLPGSAE---PPLTAVRPEGSE 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_001286712.1	LRR_RI	<31..176	CDD:238064	54/255 (21%)
		leucine-rich repeat	47..70	CDD:275378	3/22 (14%)
		LRR_8	71..124	CDD:290566	27/131 (21%)
		leucine-rich repeat	73..93	CDD:275378	9/39 (23%)
		leucine-rich repeat	94..112	CDD:275378	9/39 (23%)
		LRR_8	112..169	CDD:290566	21/114 (18%)
		leucine-rich repeat	114..134	CDD:275378	6/45 (13%)
		leucine-rich repeat	136..158	CDD:275378	9/22 (41%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
RTN4R	NP_075380.1	LRR 1. /evidence=ECO:0000255	55..79		3/23 (13%)
		leucine-rich repeat	60..82	CDD:275380	3/21 (14%)
		LRR 2. /evidence=ECO:0000255	81..103		6/21 (29%)
		LRR_8	82..142	CDD:338972	14/59 (24%)
		leucine-rich repeat	83..106	CDD:275380	6/22 (27%)
		LRR 3. /evidence=ECO:0000255	104..128		8/23 (35%)
		leucine-rich repeat	107..131	CDD:275380	7/23 (30%)
		LRR 4. /evidence=ECO:0000255	129..152		5/22 (23%)
		leucine-rich repeat	132..155	CDD:275380	6/22 (27%)
		LRR 5. /evidence=ECO:0000255	153..176		0/22 (0%)
		LRR_8	156..214	CDD:338972	5/57 (9%)
		leucine-rich repeat	156..179	CDD:275380	0/22 (0%)
		LRR 6. /evidence=ECO:0000255	178..200		5/21 (24%)
		leucine-rich repeat	180..203	CDD:275380	4/22 (18%)
		LRR 7. /evidence=ECO:0000255	202..224		0/21 (0%)
		LRR_8	203..261	CDD:338972	12/57 (21%)
		leucine-rich repeat	204..227	CDD:275380	0/22 (0%)
		LRR 8. /evidence=ECO:0000255	225..248		9/22 (41%)
		leucine-rich repeat	228..251	CDD:275380	9/22 (41%)
		LRR 9. /evidence=ECO:0000255	250..273		6/22 (27%)
		TPKR_C2	260..>296	CDD:387596	9/36 (25%)
		DUF390	332..>417	CDD:282014	15/78 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..447		14/64 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100