Protein Alignment wdp and Slit1

DIOPT Version :10

• Sequence 1: NP_611661.1
• Gene: wdp / 37548
• FlyBaseID: FBgn0034718
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_075242.1
• Gene: Slit1 / 65047
• RGDID: 69307
• Length: 1531
• Species: Rattus norvegicus
• Alignment Length: 467
• Identity: 100/467 - (21%)
• Similarity: 157/467 - (33%)
• Gaps: 142/467 - (30%)

  Fly    12 LFLIVVANATPTPARTPTGCPADCTCSLSQHTHKPLYHLKCNSTRGLRLTEKTF----------- 65
            |:|::.|.|....|   |.|||.|||:.:.        :.|:.| ||:...|..
  Rat    18 LWLLLWAAAWRLGA---TACPALCTCTGTT--------VDCHGT-GLQAIPKNIPRNTERLELNG 70

  Fly    66 QSTVPVHSIDLSHLNLTRLSHLL------------DKLPELTSADLSHNQLKDLGHL----GKGL 114
            .:...:|..|.:.|...|:..|:            |.:.||....|:.|||:.|..|    .:.|
  Rat    71 NNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQAL 135

  Fly   115 KRLNLKHNQLTS-----------------DK----------LRKLPQHLQVLNLQHNNITHLPL- 151
            .||:|..|.|.:                 ||          .|.| :.|:||.|.:||||.:|:
  Rat   136 SRLDLSENSLQAVPRKAFRGATDLKNLQLDKNQISCIEEGAFRAL-RGLEVLTLNNNNITTIPVS 199

  Fly   152 ELTHMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPVV-----CSYPLEFRGRSWLQLKQ 211
            ...||.:|....|..|.:.|.|....:..||.:|      |.:     ||.|...||.:..::::
  Rat   200 SFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQR------PTIGLFTQCSGPASLRGLNVAEVQK 258

  Fly   212 DEICKKEKYQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVGNPAATAKKVRSPQIPLPS 276
            .|.....:.:........|..|..||..|......:..||....|..|
  Rat   259 SEFSCSGQGEAAQVPACTLSSGSCPAMCSCSNGIVDCRGKGLTAIPAN----------------- 306

  Fly   277 DQVEGSGDLSETNMELKL--------------PEETVAEPEAAESQLV----DAAASPSVLEEHI 323
                    |.||..|::|              |...:...:.:.:|:.    ||......|...:
  Rat   307 --------LPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLV 363

  Fly   324 VKDEDEDDEGSGSGGGL----LIIPDPSKVKITSED----------------DIDSDGKPEESDV 368
            :......|...|..|||    |::.:.:|:.....|                .|.|..|...:.:
  Rat   364 LYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSL 428

  Fly   369 RPLENPENSENP 380
            |.::....::||
  Rat   429 RAIQTLHLAQNP 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_611661.1	leucine-rich repeat	47..70	CDD:275378	5/33 (15%)
		LRR	<72..>169	CDD:443914	38/140 (27%)
		leucine-rich repeat	73..93	CDD:275378	5/31 (16%)
		leucine-rich repeat	94..112	CDD:275378	7/21 (33%)
		leucine-rich repeat	114..134	CDD:275378	10/46 (22%)
		leucine-rich repeat	136..158	CDD:275378	11/22 (50%)
		leucine-rich repeat	159..171	CDD:275378	3/11 (27%)
Slit1	NP_075242.1	LRR	<43..>217	CDD:443914	43/183 (23%)
		leucine-rich repeat	43..62	CDD:275380	5/27 (19%)
		LRR 1	62..83		2/20 (10%)
		leucine-rich repeat	63..86	CDD:275380	3/22 (14%)
		LRR 2	86..107		2/20 (10%)
		leucine-rich repeat	87..110	CDD:275380	3/22 (14%)
		LRR 3	110..131		8/20 (40%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR 4	134..155		6/20 (30%)
		leucine-rich repeat	135..158	CDD:275380	6/22 (27%)
		LRR 5	158..179		2/20 (10%)
		leucine-rich repeat	159..182	CDD:275380	4/23 (17%)
		LRR 6	182..203		9/20 (45%)
		leucine-rich repeat	183..206	CDD:275380	11/22 (50%)
		PCC	188..>328	CDD:188093	37/170 (22%)
		leucine-rich repeat	207..334	CDD:275380	30/157 (19%)
		LRR 7	310..331		3/20 (15%)
		LRR_8	312..369	CDD:404697	7/56 (13%)
		LRR 8	334..355		3/20 (15%)
		leucine-rich repeat	335..358	CDD:275380	3/22 (14%)
		LRR 9	358..379		3/20 (15%)
		leucine-rich repeat	359..379	CDD:275380	3/19 (16%)
		LRR 10	382..403		3/20 (15%)
		leucine-rich repeat	383..406	CDD:275380	3/22 (14%)
		LRR_8	389..441	CDD:404697	8/52 (15%)
		LRR 11	406..427		3/20 (15%)
		leucine-rich repeat	407..428	CDD:275380	3/20 (15%)
		PCC	412..>475	CDD:188093	6/29 (21%)
		leucine-rich repeat	431..528	CDD:275380	2/10 (20%)
		LRRNT	512..544	CDD:214470
		leucine-rich repeat	529..566	CDD:275380
		LRR 12	541..562
		LRR	<543..>820	CDD:443914
		LRR 13	566..587
		leucine-rich repeat	567..590	CDD:275380
		LRR 14	590..611
		leucine-rich repeat	591..614	CDD:275380
		LRR 15	614..635
		leucine-rich repeat	615..638	CDD:275380
		LRR 16	638..659
		leucine-rich repeat	639..660	CDD:275380
		PCC	644..>730	CDD:188093
		leucine-rich repeat	663..754	CDD:275380
		LRRNT	733..760	CDD:396168
		leucine-rich repeat	755..785	CDD:275380
		LRR 17	762..783
		LRR 18	785..806
		leucine-rich repeat	786..809	CDD:275380
		LRR 19	809..830
		leucine-rich repeat	810..830	CDD:275380
		LRR 20	833..854
		leucine-rich repeat	834..857	CDD:275380
		PCC	842..>1002	CDD:188093
		EGF_CA	1005..1041	CDD:238011
		EGF_CA	1044..1080	CDD:238011
		EGF_CA	1085..1119	CDD:238011
		LamG	1186..1319	CDD:214598