DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdp and lrrc4cb

DIOPT Version :9

Sequence 1:	NP_001286712.1	Gene:	wdp / 37548	FlyBaseID:	FBgn0034718	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_005166545.1	Gene:	lrrc4cb / 564462	ZFINID:	ZDB-GENE-080327-5	Length:	631	Species:	Danio rerio

Alignment Length:	717	Identity:	142/717 - (19%)
Similarity:	218/717 - (30%)	Gaps:	299/717 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AW--------LALFLIVVANATPTPARTPTGCPADCTCS-------------------LSQHTH- 44
            ||        |||.|:|||..    .|..| ||:.|:||                   :|.:|.
Zfish    22 AWFDPLFLLLLALQLLVVAGL----VRAQT-CPSVCSCSNQFSKVICTRRGLKDVPDGVSTNTRY 81

  Fly    45 ----------------KPLYHLKC-----NSTRGLRLTEKTFQSTVPVHSIDLSHLNLTRL---- 84
                            |.|.||:.     |..|.:.:  ..|.....:::::|....||.:
Zfish    82 LNLQDNQIQVIKVDSFKHLRHLEILQLSRNHIRNIEI--GAFNGLTSLNTLELFDNRLTTIPNGA 144

  Fly    85 ---------------------SHLLDKLPELTSADLSHNQLKDLGHLGKG--------------- 113
                                 |....:||.|...||  .:||.|.::..|
Zfish   145 FEYLSKLKELWLRNNPIESIPSDAFSRLPSLRRLDL--GELKRLSYISSGAFQGLSNLRYLNLGM 207

  Fly   114 --------------LKRLNLKHNQLT-----SDK----LRKL-PQHLQV---------------- 138
                          |..|.:..||||     |.|    |:|| ..|.||
Zfish   208 CNLKEVPNIQPLIRLDELEMSGNQLTVIQPSSFKGLVHLQKLWMMHAQVQTIERNSFDDLHSLRE 272

  Fly   139 LNLQHNNITHLPLEL-THMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHP------VVCS 196
            |||.|||:|.||.:| |.:|.|.::.|.||..||:|..|.:..||.|.:     |      ..|:
Zfish   273 LNLAHNNLTFLPHDLYTPLHHLQRVHLHHNPWNCNCDILWLSWWLRETV-----PTNTSCCARCN 332

  Fly   197 YPLEFRGRSWLQLKQDEICKKEKYQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVGNP- 260
            .|...:||...:|.|         .:|..                           :.|::..|
Zfish   333 SPPSLKGRYIGELDQ---------SYFQC---------------------------YAPVIIEPP 361

  Fly   261 --------AATAKKVRSPQIPLPS-----------------DQVEGSGDLSETNMELKLPEETVA 300
                    .|...|.|:..:...|                 ..|:..|.|:.||:.|:
Zfish   362 VDLNLTEGMAAELKCRTNSVTSVSWLTPNGSIITHGTLKMRINVQNDGTLNFTNVTLQ------- 419

  Fly   301 EPEAAESQLVDAAASPSVLEEHIVKDEDEDDEGSGSGGGLLIIPDPSKVKITSEDDIDSDGKP-- 363
                      |.......:...:         |:.|...:|        .:||   :|:.|..
Zfish   420 ----------DTGTYTCYVSNML---------GNTSASAIL--------NVTS---VDNSGFSYF 454

  Fly   364 EESDVRPLENPENSENPDTVFSNKIGIYEGDQEEKKPVEEDNIVPVVMTNLDTGLESDVVTDGPL 428
            ....|..:|.|.:.|: .|......|..........|:..:....:.:|.:|        .||.|
Zfish   455 TTVTVETIETPIDGES-RTPVQPSFGWASSSTTRGTPIATERAYTIPVTEID--------IDGAL 510

  Fly   429 DSSKESEDILTAKIGKPKDDSSAIYYLLAVIGLIVVGLVLFVAIKRCKY--DSNAAARDAEA--- 488
            :..:|.  :.|.||        .|...:|:..:..|.|::|..:::..:  |.:..:|..|.
Zfish   511 NGLEEV--MKTTKI--------IIGCFVAITLMAAVMLIIFYKMRKQHHQQDHDGPSRSMEIISV 565

  Fly   489 -QRQTELLDMDKKQLGKPL---HKNGHGNGQE----------------HSPLI---GEKTKLDEA 530
             :..|.:..|:......||   |.| |.|..:                |.||:   ..|..:.|.
Zfish   566 HEDLTRVPAMESHLTLPPLEHDHYN-HYNSYKTAYNHVSALSSLHSSVHEPLLIQASSKDNVQET 629

  Fly   531 QI 532
            ||
Zfish   630 QI 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_001286712.1	LRR_RI	<31..176	CDD:238064	60/266 (23%)
		leucine-rich repeat	47..70	CDD:275378	6/27 (22%)
		LRR_8	71..124	CDD:290566	16/106 (15%)
		leucine-rich repeat	73..93	CDD:275378	5/44 (11%)
		leucine-rich repeat	94..112	CDD:275378	6/17 (35%)
		LRR_8	112..169	CDD:290566	31/112 (28%)
		leucine-rich repeat	114..134	CDD:275378	11/29 (38%)
		leucine-rich repeat	136..158	CDD:275378	13/38 (34%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
lrrc4cb	XP_005166545.1	LRRNT	48..81	CDD:214470	7/32 (22%)
		LRR_8	77..137	CDD:290566	9/61 (15%)
		leucine-rich repeat	79..102	CDD:275380	3/22 (14%)
		LRR_RI	82..>281	CDD:238064	40/202 (20%)
		leucine-rich repeat	103..126	CDD:275380	4/24 (17%)
		LRR_8	125..180	CDD:290566	7/54 (13%)
		leucine-rich repeat	127..150	CDD:275380	3/22 (14%)
		leucine-rich repeat	151..174	CDD:275380	2/22 (9%)
		leucine-rich repeat	175..199	CDD:275380	7/25 (28%)
		leucine-rich repeat	200..221	CDD:275380	0/20 (0%)
		LRR_8	221..280	CDD:290566	19/58 (33%)
		leucine-rich repeat	222..245	CDD:275380	8/22 (36%)
		leucine-rich repeat	246..269	CDD:275380	6/22 (27%)
		leucine-rich repeat	270..291	CDD:275380	11/20 (55%)
		LRRCT	302..352	CDD:214507	16/63 (25%)
		I-set	355..443	CDD:254352	16/121 (13%)
		Ig	372..439	CDD:143165	12/92 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100