DRSC/TRiP Functional Genomics Resources

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Protein Alignment wdp and Lrrc4b

DIOPT Version :9

Sequence 1:NP_001286712.1 Gene:wdp / 37548 FlyBaseID:FBgn0034718 Length:677 Species:Drosophila melanogaster
Sequence 2:NP_001258010.1 Gene:Lrrc4b / 308571 RGDID:1307121 Length:709 Species:Rattus norvegicus


Alignment Length:708 Identity:139/708 - (19%)
Similarity:227/708 - (32%) Gaps:231/708 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 IVVANATPTPARTPTGCPADCTCSLSQH----THKPLYHLKCN---STRGLRLTEKTFQSTVPVH 72
            :.|.:|....:...|.|||.|:||....    |.:.|..:..:   :||.|.|.|.:.|......
  Rat    43 VAVTSAAGGGSPPATSCPAACSCSNQASRVICTRRELAEVPASIPVNTRYLNLQENSIQVIRTDT 107

  Fly    73 SIDLSHLNLTRLS-HLLDK--------LPELTSADLSHNQLK----------------------- 105
            ...|.||.:.:|| :|:.|        ||.|.:.:|..|:|.                       
  Rat   108 FKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPI 172

  Fly   106 -----------------DLGHLGKGLKRL------------NLKHNQLTSDKLRKLP-------- 133
                             |||.    ||||            ||::..|....|:.:|        
  Rat   173 ESIPSYAFNRVPSLRRLDLGE----LKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPNLTALVRL 233

  Fly   134 -----------------------------QHLQV----------------LNLQHNNITHLPLEL 153
                                         .|.||                |||.|||:..||.:|
  Rat   234 EELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLPHDL 298

  Fly   154 -THMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHP------VVCSYPLEFRGRSWLQLKQ 211
             |.:|:|.::.|:||..:|:|..|.:..||.|.:     |      ..|..|...:||...:|.|
  Rat   299 FTPLHRLERVHLNHNPWHCNCDVLWLSWWLKETV-----PSNTTCCARCHAPAGLKGRYIGELDQ 358

  Fly   212 DEI-CKKEKYQWFDTE-ENELMMGDQPAAVSAEREDEEELGKDFLPIVGNPAATAKKVRSPQIPL 274
            ... |    |.....| ..:|.:.:..||....|........::|    .|..|.....|.::.:
  Rat   359 SHFTC----YAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWL----TPNGTLMTHGSYRVRI 415

  Fly   275 PSDQVEGSGDLSETNMELK-LPEETVAEPEAAESQLVDAAASPSVLEEHIVKDEDEDDEGSGSGG 338
               .|...|.|:.||:.:: ..:.|.....:|.:....|..:.|.::.  |........|.|.||
  Rat   416 ---SVLHDGTLNFTNVTVQDTGQYTCMVTNSAGNTTASATLNVSAVDP--VAAGGPGGGGPGGGG 475

  Fly   339 GLLIIPDPSKVKITSEDDIDSDGKPEESDVRPLENPENSENPDTVFSNKIGIYEGDQ-EEKKPVE 402
            |.......:.....:.:.:::  :|.|...:|....:....|.|     .|.:.|.: :...|..
  Rat   476 GAGGAGGYTYFTTVTVETLET--QPGEEAQQPRGTEKEPPGPTT-----DGAWGGGRPDAAAPAS 533

  Fly   403 EDNIVPVVMTNLDTGLESDV-VTDGPLDSSKESEDIL-TAKIGKPKDDSSAIYYLLAVIGLIVVG 465
            .....|...::..|.....| :||...::.|:.:|:: |.||        .|...:|:..:..|.
  Rat   534 ASTTAPAPRSSRPTEKAFTVPITDVTENALKDLDDVMKTTKI--------IIGCFVAITFMAAVM 590

  Fly   466 LVLFVAIKRCKYDSNAAARDAEAQRQTELLDMDKK-------------------------QLGKP 505
            ||.|..:::    .:...:.....|..|:::::.:                         .|..|
  Rat   591 LVAFYKLRK----QHQLHKHHGPTRTVEIINVEDELPAASAVSVAAAAAVAGGAGVGGDSHLALP 651

  Fly   506 L----HKNGH------------------------GNGQEHSPLI---GEKTKLDEAQI 532
            .    |.|.|                        |....|.||:   |.|..:.|.||
  Rat   652 ALERDHLNHHHYVAAAFKAHYGGNPGGGCGAKGPGLNSIHEPLLFKSGSKENVQETQI 709

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wdpNP_001286712.1 LRR_RI <31..176 CDD:238064 59/266 (22%)
leucine-rich repeat 47..70 CDD:275378 7/25 (28%)
LRR_8 71..124 CDD:290566 22/113 (19%)
leucine-rich repeat 73..93 CDD:275378 8/28 (29%)
leucine-rich repeat 94..112 CDD:275378 7/57 (12%)
LRR_8 112..169 CDD:290566 27/122 (22%)
leucine-rich repeat 114..134 CDD:275378 9/68 (13%)
leucine-rich repeat 136..158 CDD:275378 12/38 (32%)
leucine-rich repeat 159..171 CDD:275378 4/11 (36%)
Lrrc4bNP_001258010.1 LRRNT 59..92 CDD:214470 9/32 (28%)
LRR <89..299 CDD:227223 42/213 (20%)
LRR 1 89..110 6/20 (30%)
leucine-rich repeat 90..113 CDD:275380 7/22 (32%)
LRR 2 113..134 6/20 (30%)
leucine-rich repeat 114..137 CDD:275380 6/22 (27%)
LRR 3 137..158 4/20 (20%)
leucine-rich repeat 138..161 CDD:275380 4/22 (18%)
LRR 4 161..182 0/20 (0%)
leucine-rich repeat 162..185 CDD:275380 0/22 (0%)
LRR 5 185..207 7/25 (28%)
leucine-rich repeat 186..210 CDD:275380 7/27 (26%)
LRR 6 210..231 5/20 (25%)
leucine-rich repeat 211..232 CDD:275380 4/20 (20%)
LRR 7 232..253 0/20 (0%)
leucine-rich repeat 233..256 CDD:275380 0/22 (0%)
LRR 8 256..277 3/20 (15%)
leucine-rich repeat 257..280 CDD:275380 3/22 (14%)
LRR 9 280..301 9/20 (45%)
leucine-rich repeat 281..302 CDD:275380 10/20 (50%)
LRRCT 313..363 CDD:214507 14/54 (26%)
I-set 366..455 CDD:400151 17/95 (18%)
Ig strand A 366..369 CDD:409353 0/2 (0%)
Ig strand A' 373..376 CDD:409353 0/2 (0%)
Ig strand B 382..389 CDD:409353 2/6 (33%)
Ig strand C 395..400 CDD:409353 1/8 (13%)
Ig strand C' 403..405 CDD:409353 0/1 (0%)
Ig strand D 414..418 CDD:409353 0/6 (0%)
Ig strand E 421..425 CDD:409353 2/3 (67%)
Ig strand F 435..442 CDD:409353 1/6 (17%)
Ig strand G 445..455 CDD:409353 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..552 10/62 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24369
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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