DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wdp and Lrrc3

DIOPT Version :9

Sequence 1:	NP_001286712.1	Gene:	wdp / 37548	FlyBaseID:	FBgn0034718	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_660134.1	Gene:	Lrrc3 / 237387	MGIID:	2447899	Length:	257	Species:	Mus musculus

Alignment Length:	275	Identity:	61/275 - (22%)
Similarity:	106/275 - (38%)	Gaps:	70/275 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RTPTGCPADCTCSLSQHTHKPLYHLKCNSTRGLRLTEKTFQSTVPVHSIDLSHLNLTRLSHL--- 87
            |....||..|.|.    .|.....:.| |:|||    :.....:|..:: |..|:..|:|.:
Mouse    28 RLGASCPQACQCP----DHAGAVAVHC-SSRGL----QEIPRDIPADTV-LLKLDANRISRVPNG 82

  Fly    88 -LDKLPELTSADLSHNQLKDLG-----HLGKGLKRLNLKHNQLTSDKLRKLPQH-LQVLNLQHNN 145
             ...||:|...|||||.::.:|     .|..||:.|:|.||     ::|::|:. |..|:.
Mouse    83 AFQHLPQLRELDLSHNAIEAIGPAAFSGLAGGLRLLDLSHN-----RIRRIPKDALGKLSA---- 138

  Fly   146 ITHLPLELTHMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPVVC--SYPLEFRGRSWLQ 208
                           ::.||||.::|.| .|:...|.::........:.|  |...:|.|:..:|
Mouse   139 ---------------KIRLSHNPLHCEC-ALQEALWELKLDPDSVDEIACHTSAQEQFVGKPLIQ 187

  Fly   209 LKQD--EICKKEK-----------YQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVGNP 260
            :...  ..|...:           :.||     .:::.   ..|...|.::|:..:....:...|
Mouse   188 VLDSGASFCSTHRKTTDVAMLVTMFGWF-----TMVIA---YVVYYVRHNQEDARRHLEYLKSLP 244

  Fly   261 AATAKKVRSPQIPLP 275
            :|...|  .|..|:|
Mouse   245 SAPVSK--EPLSPVP 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_001286712.1	LRR_RI	<31..176	CDD:238064	41/154 (27%)
		leucine-rich repeat	47..70	CDD:275378	5/22 (23%)
		LRR_8	71..124	CDD:290566	20/61 (33%)
		leucine-rich repeat	73..93	CDD:275378	5/23 (22%)
		leucine-rich repeat	94..112	CDD:275378	8/22 (36%)
		LRR_8	112..169	CDD:290566	14/57 (25%)
		leucine-rich repeat	114..134	CDD:275378	6/19 (32%)
		leucine-rich repeat	136..158	CDD:275378	2/21 (10%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
Lrrc3	NP_660134.1	LRRNT	33..68	CDD:214470	11/44 (25%)
		leucine-rich repeat	48..68	CDD:275378	6/25 (24%)
		LRR 1	65..86		4/21 (19%)
		LRR_8	69..125	CDD:290566	19/60 (32%)
		LRR_4	69..105	CDD:289563	11/35 (31%)
		leucine-rich repeat	69..89	CDD:275378	4/19 (21%)
		LRR_4	88..129	CDD:289563	16/45 (36%)
		LRR 2	89..110		7/20 (35%)
		leucine-rich repeat	90..114	CDD:275378	8/23 (35%)
		LRR 3	114..135		9/25 (36%)
		leucine-rich repeat	115..138	CDD:275378	9/27 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100