Protein Alignment wdp and Slit1

DIOPT Version :10

• Sequence 1: NP_611661.1
• Gene: wdp / 37548
• FlyBaseID: FBgn0034718
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_056563.2
• Gene: Slit1 / 20562
• MGIID: 1315203
• Length: 1531
• Species: Mus musculus
• Alignment Length: 466
• Identity: 99/466 - (21%)
• Similarity: 156/466 - (33%)
• Gaps: 140/466 - (30%)

  Fly    12 LFLIVVANATPTPARTPTGCPADCTCSLSQHTHKPLYHLKCNSTRGLRLTEKTF----------- 65
            |:|::.|.|....|   |.|||.|||:.:.        :.|:.| ||:...|..
Mouse    18 LWLLLWAAAWRLGA---TACPALCTCTGTT--------VDCHGT-GLQAIPKNIPRNTERLELNG 70

  Fly    66 QSTVPVHSIDLSHLNLTRLSHLL------------DKLPELTSADLSHNQLKDLGHL----GKGL 114
            .:...:|..|.:.|...|:..|:            |.:.||....|:.|||:.|..|    .:.|
Mouse    71 NNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLQVLPELLFQNNQAL 135

  Fly   115 KRLNLKHN-----------------QLTSDKLR---------KLPQHLQVLNLQHNNITHLPL-E 152
            .||:|..|                 .|..||.|         :..:.|:||.|.:||||.:|: .
Mouse   136 SRLDLSENFLQAVPRKAFRGATDLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSS 200

  Fly   153 LTHMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPVV-----CSYPLEFRGRSWLQLKQD 212
            ..||.:|....|..|.:.|.|....:..||.:|      |.:     ||.|...||.:..::::.
Mouse   201 FNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQR------PTIGLFTQCSGPASLRGLNVAEVQKG 259

  Fly   213 EICKKEKYQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVGNPAATAKKVRSPQIPLPSD 277
            |.....:.:........|..|..||..|......:..||....|..|
Mouse   260 EFSCSGQGEAAGAPACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPAN------------------ 306

  Fly   278 QVEGSGDLSETNMELKL--------------PEETVAEPEAAESQLV----DAAASPSVLEEHIV 324
                   |.||..|::|              |...:...:.:.:|:.    ||......|...::
Mouse   307 -------LPETMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVL 364

  Fly   325 KDEDEDDEGSGSGGGL----LIIPDPSKVKITSED----------------DIDSDGKPEESDVR 369
            ......|...|..|||    |::.:.:|:.....|                .|.|..|...:.:|
Mouse   365 YGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLR 429

  Fly   370 PLENPENSENP 380
            .::....::||
Mouse   430 AIQTLHLAQNP 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_611661.1	leucine-rich repeat	47..70	CDD:275378	5/33 (15%)
		LRR	<72..>169	CDD:443914	37/139 (27%)
		leucine-rich repeat	73..93	CDD:275378	5/31 (16%)
		leucine-rich repeat	94..112	CDD:275378	7/21 (33%)
		leucine-rich repeat	114..134	CDD:275378	9/45 (20%)
		leucine-rich repeat	136..158	CDD:275378	11/22 (50%)
		leucine-rich repeat	159..171	CDD:275378	3/11 (27%)
Slit1	NP_056563.2	LRR	<43..>217	CDD:443914	42/182 (23%)
		leucine-rich repeat	43..62	CDD:275380	5/27 (19%)
		LRR 1	62..83		2/20 (10%)
		leucine-rich repeat	63..86	CDD:275380	3/22 (14%)
		LRR 2	86..107		2/20 (10%)
		leucine-rich repeat	87..110	CDD:275380	3/22 (14%)
		LRR 3	110..131		8/20 (40%)
		leucine-rich repeat	111..134	CDD:275380	7/22 (32%)
		LRR 4	134..155		5/20 (25%)
		leucine-rich repeat	135..158	CDD:275380	5/22 (23%)
		LRR 5	158..179		4/20 (20%)
		leucine-rich repeat	159..182	CDD:275380	4/22 (18%)
		LRR 6	182..203		9/20 (45%)
		leucine-rich repeat	183..206	CDD:275380	11/22 (50%)
		PCC	188..>328	CDD:188093	37/170 (22%)
		leucine-rich repeat	207..334	CDD:275380	30/157 (19%)
		LRR 7	310..331		3/20 (15%)
		LRR_8	312..369	CDD:404697	7/56 (13%)
		LRR 8	334..355		3/20 (15%)
		leucine-rich repeat	335..358	CDD:275380	3/22 (14%)
		LRR 9	358..379		3/20 (15%)
		leucine-rich repeat	359..379	CDD:275380	3/19 (16%)
		LRR 10	382..403		3/20 (15%)
		leucine-rich repeat	383..406	CDD:275380	3/22 (14%)
		LRR_8	389..441	CDD:404697	8/52 (15%)
		LRR 11	406..427		3/20 (15%)
		leucine-rich repeat	407..428	CDD:275380	3/20 (15%)
		PCC	412..>475	CDD:188093	6/29 (21%)
		leucine-rich repeat	431..528	CDD:275380	2/10 (20%)
		LRR	522..>820	CDD:443914
		leucine-rich repeat	529..566	CDD:275380
		LRR 12	541..562
		LRR 13	566..587
		leucine-rich repeat	567..590	CDD:275380
		LRR 14	590..611
		leucine-rich repeat	591..614	CDD:275380
		LRR 15	614..635
		leucine-rich repeat	615..638	CDD:275380
		LRR 16	638..659
		leucine-rich repeat	639..660	CDD:275380
		PCC	644..>730	CDD:188093
		leucine-rich repeat	663..754	CDD:275380
		LRRNT	733..760	CDD:396168
		leucine-rich repeat	755..785	CDD:275380
		LRR 17	762..783
		LRR 18	785..806
		leucine-rich repeat	786..809	CDD:275380
		LRR 19	809..830
		leucine-rich repeat	810..830	CDD:275380
		LRR 20	833..854
		leucine-rich repeat	834..857	CDD:275380
		PCC	842..>1002	CDD:188093
		EGF_CA	1005..1041	CDD:238011
		EGF_CA	1044..1080	CDD:238011
		EGF_CA	1085..1119	CDD:238011
		LamG	1186..1319	CDD:214598