Protein Alignment wdp and SLITRK4

DIOPT Version :10

• Sequence 1: NP_611661.1
• Gene: wdp / 37548
• FlyBaseID: FBgn0034718
• Length: 677
• Species: Drosophila melanogaster
• Sequence 2: NP_775101.1
• Gene: SLITRK4 / 139065
• HGNCID: 23502
• Length: 837
• Species: Homo sapiens
• Alignment Length: 557
• Identity: 119/557 - (21%)
• Similarity: 200/557 - (35%)
• Gaps: 187/557 - (33%)

  Fly    16 VVANATPTPARTPTGCPADCTC-------------------SLSQHTHKPL----YHLKCNSTRG 57
            :|:..|..|..||  |||.|.|                   |:|:...|||    .|:..||.:.
Human   329 IVSYQTRVPPLTP--CPAPCFCKTHPSDLGLSVNCQEKNIQSMSELIPKPLNAKKLHVNGNSIKD 391

  Fly    58 LRLTEKTFQSTVPVHSIDLSHL--------------NLTRLSHL------LDKL-PELTSA---- 97
            :.:::.|     ....:||.||              |||.|..|      :::| ||:.|.
Human   392 VDVSDFT-----DFEGLDLLHLGSNQITVIKGDVFHNLTNLRRLYLNGNQIERLYPEIFSGLHNL 451

  Fly    98 ---DLSHNQLKDLGHLGKGLKRLNLKHNQLTSDKLRKLPQH------LQVLNLQHNNITHLPLE- 152
               .|.:|.:|::. .|......||:...|.::.|:.||.:      |..|||::|...:||:.
Human   452 QYLYLEYNLIKEIS-AGTFDSMPNLQLLYLNNNLLKSLPVYIFSGAPLARLNLRNNKFMYLPVSG 515

  Fly   153 -LTHMHQLHQLELSHNAINCSCQTLEVRNW---LVERIVYMEHPVVCSYPLEFRGRSWLQLKQDE 213
             |..:..|.|::|..|..:|:|..:.::.|   |.:.||..|  :.|..|::|.......||.:.
Human   516 VLDQLQSLTQIDLEGNPWDCTCDLVALKLWVEKLSDGIVVKE--LKCETPVQFANIELKSLKNEI 578

  Fly   214 ICKKEKYQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVG-NPAAT----AKKVRSP--- 270
            :|.|              :.::|:|                |... .||.|    ...:|||
Human   579 LCPK--------------LLNKPSA----------------PFTSPAPAITFTTPLGPIRSPPGG 613

  Fly   271 QIPL-------------------------------PSDQVEGSG--DLSETNMELKLPEETVAEP 302
            .:||                               |:.:.||.|  |.....::|:..:....:.
Human   614 PVPLSILILSILVVLILTVFVAFCLLVFVLRRNKKPTVKHEGLGNPDCGSMQLQLRKHDHKTNKK 678

  Fly   303 EAAESQLVDAAASPSVLEEHIVKDEDEDDEGSGSGGGLLIIPDPSKVKIT-------SEDDIDSD 360
            :...::    |..|..:|: :.|......:.|.:|   .:..||...|:.       .:|.:..|
Human   679 DGLSTE----AFIPQTIEQ-MSKSHTCGLKESETG---FMFSDPPGQKVVMRNVADKEKDLLHVD 735

  Fly   361 GKPEESDVRPLEN--PENSENPDTVF----------SNKIGI--YEGDQEEKKPVEEDNIVPVVM 411
            .:...|.:..|:.  |....|   ||          .|.||:  :|....||:|.::..
Human   736 TRKRLSTIDELDELFPSRDSN---VFIQNFLESKKEYNSIGVSGFEIRYPEKQPDKKSK------ 791

  Fly   412 TNLDTGLESDVVTDGPLDSSKESEDI-LTAKIGKPKD 447
            .:|..|..|.:|.:     .::||.. |.||:....|
Human   792 KSLIGGNHSKIVVE-----QRKSEYFELKAKLQSSPD 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_611661.1	leucine-rich repeat	47..70	CDD:275378	5/26 (19%)
		LRR	<72..>169	CDD:443914	35/132 (27%)
		leucine-rich repeat	73..93	CDD:275378	10/40 (25%)
		leucine-rich repeat	94..112	CDD:275378	4/24 (17%)
		leucine-rich repeat	114..134	CDD:275378	5/19 (26%)
		leucine-rich repeat	136..158	CDD:275378	8/23 (35%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
SLITRK4	NP_775101.1	LRR	<59..>213	CDD:443914
		LRR 1	60..81
		leucine-rich repeat	63..84	CDD:275380
		LRR 2	84..105
		leucine-rich repeat	85..108	CDD:275380
		LRR 3	108..129
		leucine-rich repeat	109..132	CDD:275380
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275380
		LRR 5	156..177
		leucine-rich repeat	157..179	CDD:275380
		LRR 6	179..200
		leucine-rich repeat	180..204	CDD:275380
		leucine-rich repeat	205..295	CDD:275380
		LRRCT	213..>253	CDD:214507
		leucine-rich repeat	296..371	CDD:275380	11/43 (26%)
		LRR	<358..>531	CDD:443914	43/178 (24%)
		leucine-rich repeat	372..402	CDD:275380	7/34 (21%)
		LRR 7	378..399		4/25 (16%)
		LRR 8	402..423		4/20 (20%)
		leucine-rich repeat	403..426	CDD:275380	6/22 (27%)
		LRR 9	426..447		5/20 (25%)
		leucine-rich repeat	427..450	CDD:275380	6/22 (27%)
		LRR 10	450..471		4/21 (19%)
		leucine-rich repeat	451..472	CDD:275380	4/21 (19%)
		LRR 11	474..495		6/20 (30%)
		leucine-rich repeat	475..496	CDD:275380	5/20 (25%)
		LRR 12	497..518		7/20 (35%)
		leucine-rich repeat	498..522	CDD:275380	8/23 (35%)
		PCC	502..>563	CDD:188093	18/62 (29%)