DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdp and LRRC53

DIOPT Version :9

Sequence 1:	NP_001286712.1	Gene:	wdp / 37548	FlyBaseID:	FBgn0034718	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	NP_001369209.1	Gene:	LRRC53 / 105378803	HGNCID:	25255	Length:	1247	Species:	Homo sapiens

Alignment Length:	910	Identity:	165/910 - (18%)
Similarity:	272/910 - (29%)	Gaps:	356/910 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 RTPTGCPADCTCSLSQHT--HKPLYHLKC-NSTRGLRLTEKTFQSTVPVHSIDLSHL-NLTRLS- 85
            |....||..|.......|  |:..|.:.. .:||.|.:|:....|   :.|.:||.| ||..||
Human     3 RLVAACPESCVVCTKDVTLCHQLTYIVAAPMTTRVLIITDGYLSS---IESTNLSLLFNLALLSL 64

  Fly    86 ------------------------------------HLLDKLPELTSADLSHNQLKDLG----HL 110
                                                |...||..|....||:|.|:.|.    ..
Human    65 SRNGIEDVQEDALHGLTMLRTLLLEHNQISSSSLTDHTFSKLHSLQVLVLSNNALRTLRGSWFRN 129

  Fly   111 GKGLKRLNLKHNQLTS-----------------------------DKLRKLPQHLQVLNLQHNNI 146
            ..||.||.|..||:|:                             |..|.||| ||.::|..|.:
Human   130 TSGLTRLQLDGNQITNLTDSSFGGTNLHSLRYLDLSNNFISYIGKDAFRPLPQ-LQEVDLSRNRL 193

  Fly   147 THLPLELTHMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPV------------------ 193
            .|:|...|.:.||..|.|..|..:|:|....:..:|...|....|.:
Human   194 AHMPDVFTPLKQLILLSLDKNQWSCTCDLHPLARFLRNYIKSSAHTLRNAKDLNCQPSTAAVAAA 258

  Fly   194 --------------VCSYPLEFRGRS-------------------------------WLQLKQ-- 211
                          ..::.|..:.||                               | :|.|
Human   259 QSVLRLSETNCDSKAPNFTLVLKDRSPLLPGPDVALLTVLGFAGAVGLTCLGLVVFNW-KLHQGK 322

  Fly   212 --------------DE-ICKKEKYQWFD--------TEENELMMGDQPAAVSAEREDEEELGKDF 253
                          || :|..|...:..        |:|||:.:   .:.|.:.:|
Human   323 ANEHTSENLCCRTFDEPLCAHEARNYHTKGYCNCHLTQENEIKV---MSTVGSRKE--------- 375

  Fly   254 LPIV---GNPAATAKKVRSPQIPLPSDQVEGS------------------------GDLSETNME 291
            :|::   .:.|.:|.:         |..::||                        .:.||....
Human   376 MPLLQENSHQATSASE---------SATLDGSFRNLKKKDRGVGSTLFCQDGRLLHSECSEPPGN 431

  Fly   292 LKLPEE----TVAEPEAAES--QLVDAAASPSVLEEHIVKDEDEDDE---------GSGSGGGLL 341
            ::...|    |...|...:.  .|......|..|:.||::.||...:         .|...|..|
Human   432 MRAFNEAGLLTTYNPRKVQKLWNLEPGEVQPQTLQHHIIRTEDISSDIFRRRYATPASALAGESL 496

  Fly   342 ---IIPDPSKVKITSEDD----------IDSDG----KPEESDVRPLENPENSENPDTVFSNKIG 389
               :..:..:..|..||:          |.|..    :|||..|:.:.....|:     :.:..|
Human   497 EKRLTNESWQPPIEKEDNGLHPHRQRHFITSSSSKPCEPEEHYVQKIVQKNRSK-----YDDPCG 556

  Fly   390 I------------------------YEGDQEEKKPVEEDNIVP-VVMTNLDTGLESDVVTDGPLD 429
            :                        :|...:||||....:..| .....:::.:|..::::..:|
Human   557 LLKQSKPRYFQPNNSLICKYVPCEQFEDYMKEKKPNRRQHSKPEKEQIQINSAIEKFLMSEDNID 621

  Fly   430 SSKESEDILTAKIGKPKDDSSAIYY--LLAVIGLIVVGLVLFVAIKRCKYDSNAAARDAEAQRQT 492
            .|.     |:.|..|.......|::  .|..|...::...:....||.|..||          |.
Human   622 LSG-----LSTKTKKAYSPKRVIFHDPDLVEINRSMMSPKISTPWKRQKNQSN----------QL 671

  Fly   493 ELLDMDK------KQLGKPLHKNGHGNGQEHSP-------LIGEKTKLDEAQIVK---KPYENGE 541
            ..||:.|      :..|:....|.....::.:|       :.|:..||:.....|   .|.::..
Human   672 TKLDVKKFSNTGERNKGEKWFTNSWVLKRKRTPQSDLKGKIKGQNLKLNLHPFRKVRVHPEKSLS 736

  Fly   542 AKDGAGQQPLLNGNGSANGGTKEAPETGEPAA----------------HEYYPITP-----RYPT 585
            :.....:|.||        ..|:..:|.|..|                ..|..:|.     ::.:
Human   737 SLPKQCKQVLL--------PPKKLSKTSETEAKINTVCSADFLQQSESSNYVRLTSKRLPLKHDS 793

  Fly   586 PQSPRASKYAQQQQLAEQNN----NEPDGAYLPSSPKSGRYSPVYSPETGRVKIKLTETPKPKTP 646
            .|:|...:..::..|...||    |:       ||.:|..||..:.|:....|:     |:| ||
Human   794 KQTPYYQRNTKRAPLLSANNLRVVNQ-------SSIESSCYSAGHIPDGNTSKL-----PQP-TP 845

Fly 647 646
Human 846 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_001286712.1	LRR_RI	<31..176	CDD:238064	55/218 (25%)
		leucine-rich repeat	47..70	CDD:275378	6/23 (26%)
		LRR_8	71..124	CDD:290566	23/94 (24%)
		leucine-rich repeat	73..93	CDD:275378	11/57 (19%)
		leucine-rich repeat	94..112	CDD:275378	6/21 (29%)
		LRR_8	112..169	CDD:290566	25/85 (29%)
		leucine-rich repeat	114..134	CDD:275378	10/48 (21%)
		leucine-rich repeat	136..158	CDD:275378	7/21 (33%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
LRRC53	NP_001369209.1	LRR 1	34..55		7/23 (30%)
		LRR 2	58..79		4/20 (20%)
		LRR 3	82..102		0/19 (0%)
		LRR_8	83..143	CDD:404697	15/59 (25%)
		leucine-rich repeat	83..108	CDD:275380	3/24 (13%)
		LRR 4	108..129		6/20 (30%)
		leucine-rich repeat	109..132	CDD:275380	6/22 (27%)
		LRR_8	131..193	CDD:404697	17/62 (27%)
		LRR 5	132..153		8/20 (40%)
		leucine-rich repeat	133..158	CDD:275380	7/24 (29%)
		LRR 6	158..179		1/20 (5%)
		leucine-rich repeat	159..182	CDD:275380	3/22 (14%)
		LRR 7	182..203		8/21 (38%)
		leucine-rich repeat	183..205	CDD:275380	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..866		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	887..927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1223..1247
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100