DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdp and lrrc53

DIOPT Version :9

Sequence 1:	NP_001286712.1	Gene:	wdp / 37548	FlyBaseID:	FBgn0034718	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_021322571.1	Gene:	lrrc53 / 101882576	ZFINID:	ZDB-GENE-131121-432	Length:	838	Species:	Danio rerio

Alignment Length:	725	Identity:	139/725 - (19%)
Similarity:	215/725 - (29%)	Gaps:	318/725 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 CPADC-TCS--------LSQHTHKPLYHLKCNSTRGLRLTEKTFQSTVPVHSIDLSHL------- 79
            ||:.| .||        |......|      .||:.|.||:....|...:...|||::
Zfish    21 CPSSCLVCSEDVTICQKLRSIIDAP------GSTKALMLTDGLIDSVGSMVFSDLSNMSVLALSN 79

  Fly    80 ------------NLTRLSHL-LDK---------------LPELTSADLSHNQLKDLG----HLGK 112
                        |||.|:.| ||.               |..|.:..||:|.|||:.    ....
Zfish    80 NAISSITENAFQNLTFLTTLSLDHNHISNQALNSSTFSWLHRLETLQLSNNHLKDIDGSWFQSSI 144

  Fly   113 GLKRLNLKHNQLTS-----------------------------DKLRKLPQHLQVLNLQHNNITH 148
            .||.|.|..|.|||                             :..|:||. |:.|:|..||::.
Zfish   145 ALKTLQLDGNLLTSLNSTTFAHADLRNLEILDLSDNLIVTLGRESFRRLPS-LRRLDLSRNNLSS 208

  Fly   149 LPLELTHMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHPVVCSYPLEFRGRSWLQLKQDE 213
            .|...:::..|..|.|..|..:|||:..|:.::|                     .|::|
Zfish   209 APDAFSYLSWLSTLNLDLNRWSCSCELRELASFL---------------------NSFIQ----- 247

  Fly   214 ICKKEKYQWFDTEENELMMGDQPAAVSAEREDEEELGKDFLPIVGNPAATAKKVRSPQIPLPSDQ 278
                       ..||.|..|.:.|.|:|:                ||:.
Zfish   248 -----------APENVLYNGQKMACVNAD----------------NPSV---------------- 269

  Fly   279 VEGSGDLSETNMELKLPEETVAEPEAAESQLVDAAASP---SVLEEHIVKDEDEDDE-------- 332
                              :||.       ||.||...|   ::..|.:.|..:...:
Zfish   270 ------------------QTVL-------QLTDANCVPPNSNITVEVVAKRSNTSQQYIRNVAIA 309

  Fly   333 -------GSGSGGGLLIIPD---PSKVKITSEDDIDSDGKPEESDVRPLENPENS-----ENPDT 382
                   |.|...|::.|..   ..|.|:..|:...|:        |...:||.:     |..||
Zfish   310 VVFSFLGGVGITLGIIAIAYHKLSKKFKLMQEEHGASE--------RITSSPEMAQWNFCEGKDT 366

  Fly   383 VFSNKIGIYEGDQEEKKPVEEDNIVPVVMTNLDTGLESDVVTDGPLDSSKESEDILTAKIGKPKD 447
            : |....:|..:.:..:|.:.:          |:...||.: :......|.|...||.  ||||
Zfish   367 L-SMSHALYNSNYKSHQPWDRE----------DSPYGSDEL-ENHFTCHKCSSTALTG--GKPK- 416

  Fly   448 DSSAIYYLLAVIGLIVVGLVLFVAIKRCKYDSNAAARDAEAQRQTELLDMDKKQLGKPLHKNGHG 512
                                                |:...|:.||  ::.|..:.:.|....|.
Zfish   417 ------------------------------------RETVLQKTTE--NLQKNHMSEHLAHRQHN 443

  Fly   513 NGQEHSPLIGEKTKLDEAQIVKKPYENGEA-KDGAGQQPLLNGNGSANGGTKEAPETGEPAAHEY 576
            ..|:||.|         .|.:|..:...:| :|........:......||
Zfish   444 GNQQHSVL---------QQRIKDMHLKRQAERDSKSHLASQDFTSQRRGG--------------- 484

  Fly   577 YPITPRYPTPQSPRASKYAQQQQLAEQNNNEPDGAYLPSSPKSGRYSP---VYSPET----GRVK 634
                        |......:.||||..|:.        |:.:.|.:.|   :|:.||    ..:|
Zfish   485 ------------PDDISAVRIQQLALSNHF--------SALQRGPFRPPNHIYNEETQANHSLLK 529

  Fly   635 IKLTE-TPKP 643
            .:.:| ||:|
Zfish   530 HQASETTPRP 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_001286712.1	LRR_RI	<31..176	CDD:238064	55/221 (25%)
		leucine-rich repeat	47..70	CDD:275378	6/22 (27%)
		LRR_8	71..124	CDD:290566	23/91 (25%)
		leucine-rich repeat	73..93	CDD:275378	11/54 (20%)
		leucine-rich repeat	94..112	CDD:275378	7/21 (33%)
		LRR_8	112..169	CDD:290566	21/85 (25%)
		leucine-rich repeat	114..134	CDD:275378	10/48 (21%)
		leucine-rich repeat	136..158	CDD:275378	6/21 (29%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
lrrc53	XP_021322571.1	LRR_8	49..106	CDD:316378	14/56 (25%)
		leucine-rich repeat	51..71	CDD:275380	6/19 (32%)
		leucine-rich repeat	72..95	CDD:275380	2/22 (9%)
		LRR_8	96..156	CDD:316378	17/59 (29%)
		leucine-rich repeat	96..121	CDD:275380	5/24 (21%)
		leucine-rich repeat	122..145	CDD:275380	7/22 (32%)
		LRR_8	146..206	CDD:316378	15/60 (25%)
		leucine-rich repeat	146..171	CDD:275380	8/24 (33%)
		leucine-rich repeat	172..195	CDD:275380	2/22 (9%)
		leucine-rich repeat	196..218	CDD:275380	6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100