DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wdp and lrrc4bb

DIOPT Version :9

Sequence 1:	NP_001286712.1	Gene:	wdp / 37548	FlyBaseID:	FBgn0034718	Length:	677	Species:	Drosophila melanogaster
Sequence 2:	XP_003201401.1	Gene:	lrrc4bb / 100535350	ZFINID:	ZDB-GENE-091116-44	Length:	726	Species:	Danio rerio

Alignment Length:	833	Identity:	169/833 - (20%)
Similarity:	255/833 - (30%)	Gaps:	313/833 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WLALFLIVVANATPTPARTPTGCPADCTCSLSQH----THKPLYHLK---CNSTRGLRLTEKTFQ 66
            ||...|:......|..|.....|||.|:||....    |.|.|..:.   .::||.|.|.|.:.|
Zfish    17 WLVQLLLWPHLLGPRLAEASPACPALCSCSNQASRVICTKKSLNEVPQSISSNTRYLNLQENSIQ 81

  Fly    67 ---STVPVHSIDLSHLNLTRLSH---------LLDKLPELTSADLSHNQLK-------------- 105
               |....|   |:||.:.:||.         ..:.||.|.:.:|..|:|.
Zfish    82 VIRSDTFKH---LNHLEILQLSKNQIRQIEVGAFNGLPNLITLELFDNRLPLVPSQAFEYLSKLR 143

  Fly   106 --------------------------DLGHLGK-----------------------GLK------ 115
                                      |||.|.|                       |||
Zfish   144 ELWLRNNPIETLPAYAFHRVPSLRRLDLGELRKLSFISEAAFEGLLNLRFLNLGMCGLKDVPNLT 208

  Fly   116 ------RLNLKHNQLTSDK---------LRKL-----------------PQHLQVLNLQHNNITH 148
                  .|.|..|||...:         ||||                 .::|:.|||.||::..
Zfish   209 PLVRLEELELSGNQLGVVRPGSFQGLVSLRKLWLMHSRISVIERNAFDDLKNLEELNLSHNSLHS 273

  Fly   149 LPLEL-THMHQLHQLELSHNAINCSCQTLEVRNWLVERIVYMEHP------VVCSYPLEFRGRSW 206
            ||.:| |.:.||.::.|:||...|:|..|.:..||.|.:     |      ..|..|...:||..
Zfish   274 LPHDLFTPLQQLERVHLNHNPWVCNCDVLWLSWWLKETV-----PDNSTCCARCHAPPGTKGRYI 333

  Fly   207 LQLKQ-DEICKKEKYQWFDTE-ENELMMGDQPAAVSAEREDEEELGKDFLPIVGNPAAT-----A 264
            ..|.| |..|    |.....| ..:|.:.:..||....|........::|    .|..|     |
Zfish   334 GDLDQRDFTC----YAPVIVEPPTDLNVTEGMAAELKCRTGTSMTSVNWL----TPNGTLMTHGA 390

  Fly   265 KKVRSPQIPLPSDQVEGSGDLSETNMELKLPEET---------VAEPEAAESQLVDAAASP---- 316
            .|||.        .|...|.|:.||:.:   ::|         .|....|.:.|..:|..|
Zfish   391 YKVRI--------SVLHDGTLNFTNVTM---QDTGPYTCMVTNSAGNTTATAVLNVSAPDPGNGY 444

  Fly   317 SVLEEHIVKDEDEDDEGSGSGGGLLI------IPDPSKVKITSEDDIDSDGKPEESDVRPLENPE 375
            |......|:..:...||..|.....:      .|.|:..        .:...|..|.:..| :|.
Zfish   445 SYFTTVTVETVETGQEGHDSPARQFVNETFISFPGPTAA--------STSAGPTGSMLSSL-SPR 500

  Fly   376 NSENPDTVFSNKIGIYEGDQEEKKPVEEDNIVPVVMTNLDTGLESDVVTDGPLDSSKESEDILTA 440
            .:..||..|:..|                    ..:.|| :|||         |..|.::.|:..
Zfish   501 ATRAPDRPFTVSI--------------------TDVANL-SGLE---------DVMKTTKIIIGC 535

  Fly   441 KIGKPKDDSSAIYYLLAVIGLIVVGLVLFVAIKRCKYDSNAAARDAEAQRQTELLDMDKKQLGKP 505
            .:        ||.::.||:      ||:|..:::              |.|
Zfish   536 FV--------AITFMAAVM------LVVFYKLRK--------------QHQ-------------- 558

  Fly   506 LHKNGHGNGQEHSPLIGEKTKLDEAQIVKKPYENGEAKDGAGQQPLLNGNGSANGGTKEAPETGE 570
            |||: ||..:             ..:|:....|.|.|...:|    :.|..:.:.|......:|:
Zfish   559 LHKH-HGPAR-------------AIEIINVEDEIGSAGGASG----ITGGSTVHTGAGTGGGSGQ 605

  Fly   571 -PAAHEYYPITPRYPTPQSPRASKYAQQQQLAEQNNNEPDGAYLPSSPKSGRYSPVYSPETGRVK 634
             |..|:     |...|..|...:.:......|...||...|..:.:...:.:.:|....:...:|
Zfish   606 SPRIHD-----PEIMTLPSVGQADHLNHYYKAHHFNNNVLGLNMTTGMLNNKPNPSSQNQASTLK 665

  Fly   635 IKLTETPKPKTPMLVTRSKSNAGDIITTP--VRPIEPT--------HQVINGH 677
            :                  ..|||:...|  :.|..|.        |..:.||
Zfish   666 M------------------GPAGDLGPNPGSISPPLPIPIPMAMTFHGSLKGH 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wdp	NP_001286712.1	LRR_RI	<31..176	CDD:238064	62/265 (23%)
		leucine-rich repeat	47..70	CDD:275378	8/28 (29%)
		LRR_8	71..124	CDD:290566	23/136 (17%)
		leucine-rich repeat	73..93	CDD:275378	6/28 (21%)
		leucine-rich repeat	94..112	CDD:275378	8/57 (14%)
		LRR_8	112..169	CDD:290566	28/118 (24%)
		leucine-rich repeat	114..134	CDD:275378	11/57 (19%)
		leucine-rich repeat	136..158	CDD:275378	10/22 (45%)
		leucine-rich repeat	159..171	CDD:275378	4/11 (36%)
lrrc4bb	XP_003201401.1	LRRNT	38..72	CDD:214470	10/33 (30%)
		LRR_8	68..128	CDD:290566	18/62 (29%)
		leucine-rich repeat	70..93	CDD:275380	9/25 (36%)
		LRR_RI	85..293	CDD:238064	43/210 (20%)
		leucine-rich repeat	94..117	CDD:275380	4/22 (18%)
		leucine-rich repeat	118..141	CDD:275380	4/22 (18%)
		LRR_8	140..196	CDD:290566	5/55 (9%)
		leucine-rich repeat	142..165	CDD:275380	0/22 (0%)
		leucine-rich repeat	166..190	CDD:275380	5/23 (22%)
		leucine-rich repeat	191..212	CDD:275380	3/20 (15%)
		LRR_8	212..271	CDD:290566	15/58 (26%)
		leucine-rich repeat	213..236	CDD:275380	5/22 (23%)
		leucine-rich repeat	237..260	CDD:275380	4/22 (18%)
		leucine-rich repeat	261..282	CDD:275380	10/20 (50%)
		TPKR_C2	293..343	CDD:301599	15/54 (28%)
		IG_like	352..435	CDD:214653	20/97 (21%)
		Ig	360..435	CDD:299845	19/89 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24369
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100