DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5819 and Lingo3

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001103079.1	Gene:	Lingo3 / 690755	RGDID:	1592209	Length:	589	Species:	Rattus norvegicus

Alignment Length:	562	Identity:	134/562 - (23%)
Similarity:	198/562 - (35%)	Gaps:	177/562 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLELALLVLGVISSCRAVNCPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPVE--HLDLSGNKF 66
            :|.|.||:|.  ::..|..||..|.|:  ..:....|.||.|...|  :|||.|  .|:||.|:.
  Rat     7 MLGLHLLLLP--TAPLATGCPARCECS--ASTRTVACGRRRLTAVP--EGIPAETRMLELSRNRI 65

  Fly    67 LEF-PTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFKYAPS 130
            ... |...|.:.:|..|||:.|.|:.:..........||.|.|..|.:    .|.|...|.:..|
  Rat    66 RCLNPGDLASLPTLEELDLNHNVIAHVEPGAFANLPRLRVLRLRGNQL----KLIPPGVFTHLDS 126

  Fly   131 LKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQ 195
            |..|.|..|:|         .:|...|..|                   |.:|:||.:.:|.|..
  Rat   127 LTLLDLSENKL---------VILLDFSFQD-------------------LRSLQRLEVGDNDLVF 163

  Fly   196 IAALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYMLRKLDVS 260
            |             |..:...|.|                                  |.:|.:.
  Rat   164 I-------------SRRAFAGLLG----------------------------------LAELTLE 181

  Fly   261 YCNLDSIELSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHI-GQDAFAKLKRLK 324
            .|||.|                                     ||...|.|: |..|.    ||:
  Rat   182 RCNLTS-------------------------------------LSPESLGHLRGLGAL----RLR 205

  Fly   325 ELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCEITSIESTALSSL 389
            .|.:|..|    |:|| :....|:.|.:....|  |.::...|:|.:|::...||....||:.:.
  Rat   206 HLAIAALE----DQNF-QKLPGLLHLEIDNWPL--LEEVAPGSLRGLNLTSLSITHTNITAVPAA 263

  Fly   390 SVIQK-----LDLSNNLITDMP--TFMRSETLQQLNLANCRLTTVRNNTFREFPELADLHLNGNR 447
            ::.|:     |:||:|.|:.:|  :|.....|::|:||...|..:....|....::..|:|:.|
  Rat   264 ALRQQAHLTCLNLSHNPISMVPRGSFRDLVRLRELHLAGALLAVIEPQAFVGLRQIRLLNLSDN- 327

  Fly   448 LTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFV------DFYDYLTAKPAKIKDRNHLRCAA 506
            |.|.:..|.|.....|:.|.:..||..|||.....|      :|...|.|            ||.
  Rat   328 LLSTLEENTFHSVNTLETLRVDGNPLACDCRLLWIVQRRKTLNFDGRLPA------------CAT 380

  Fly   507 PAVFYGK---------LWE-FACADVWILNAR----TSSTGE 534
            ||...|.         |:| |.|....|...|    |::.|:
  Rat   381 PAEVRGDALHNLPDSVLFEYFVCRKPKIRERRLQHVTATEGD 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	7/24 (29%)
		LRR_RI	<58..236	CDD:238064	39/178 (22%)
		LRR_8	78..141	CDD:290566	19/62 (31%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..130	CDD:275380	8/26 (31%)
		leucine-rich repeat	131..155	CDD:275380	6/23 (26%)
		LRR_8	156..214	CDD:290566	10/57 (18%)
		leucine-rich repeat	158..182	CDD:275380	2/23 (9%)
		LRR_8	202..285	CDD:290566	9/82 (11%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	254..274	CDD:275380	6/19 (32%)
		LRR_8	273..333	CDD:290566	10/60 (17%)
		leucine-rich repeat	275..298	CDD:275380	0/22 (0%)
		LRR_RI	277..>471	CDD:238064	48/201 (24%)
		leucine-rich repeat	299..322	CDD:275380	6/23 (26%)
		LRR_8	321..402	CDD:290566	24/85 (28%)
		leucine-rich repeat	323..346	CDD:275380	7/22 (32%)
		leucine-rich repeat	347..391	CDD:275380	11/43 (26%)
		leucine-rich repeat	392..413	CDD:275380	8/27 (30%)
		LRR_8	393..448	CDD:290566	17/61 (28%)
		leucine-rich repeat	414..437	CDD:275380	6/22 (27%)
		LRRCT	471..517	CDD:214507	16/61 (26%)
Lingo3	NP_001103079.1	LRRNT	23..55	CDD:214470	12/35 (34%)
		leucine-rich repeat	34..53	CDD:275380	7/20 (35%)
		LRR	<55..353	CDD:227223	94/425 (22%)
		leucine-rich repeat	55..78	CDD:275380	6/22 (27%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..150	CDD:275380	18/78 (23%)
		leucine-rich repeat	151..174	CDD:275380	8/35 (23%)
		leucine-rich repeat	175..198	CDD:275380	10/59 (17%)
		leucine-rich repeat	199..222	CDD:275380	9/31 (29%)
		leucine-rich repeat	223..246	CDD:275380	6/24 (25%)
		LRR_8	246..302	CDD:404697	16/55 (29%)
		leucine-rich repeat	247..270	CDD:275380	5/22 (23%)
		leucine-rich repeat	271..292	CDD:275380	7/20 (35%)
		leucine-rich repeat	295..316	CDD:275380	6/20 (30%)
		leucine-rich repeat	319..342	CDD:275380	7/23 (30%)
		PCC	331..>405	CDD:188093	22/85 (26%)
		Ig	407..489	CDD:416386	4/16 (25%)
		Ig strand A'	413..417	CDD:409353	0/3 (0%)
		Ig strand B	423..432	CDD:409353	134/562 (24%)
		Ig strand C	437..442	CDD:409353
		Ig strand C'	445..447	CDD:409353
		Ig strand D	456..459	CDD:409353
		Ig strand E	462..469	CDD:409353
		Ig strand F	475..483	CDD:409353
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348969
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930