Protein Alignment CG5819 and Nepn

DIOPT Version :9

• Sequence 1: NP_001246458.1
• Gene: CG5819 / 37547
• FlyBaseID: FBgn0034717
• Length: 915
• Species: Drosophila melanogaster
• Sequence 2: XP_006512881.1
• Gene: Nepn / 66650
• MGIID: 1913900
• Length: 561
• Species: Mus musculus
• Alignment Length: 526
• Identity: 135/526 - (25%)
• Similarity: 229/526 - (43%)
• Gaps: 91/526 - (17%)

  Fly    11 VLGV-ISSCRAVNCPWPCRCTWVVDSLYA-DCSRRSLQTYPNFDGIP------------VEHLDL 61
            :||: :::..:.|||..|.|    ||:.: .|.|  |...|:  |||            ::||.|
Mouse    57 LLGLSLTNGLSANCPGRCSC----DSMQSVQCYR--LMELPS--GIPSTTKRLYISHSRIQHLQL 113

  Fly    62 SGNKFLEFPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFK 126
            |     .|..|.| ::..|.|...:..|.:...|||   ::|:||.|..|.:....|..|
Mouse   114 S-----NFTGLLA-LEDFILLASGTESIENDTFKTL---STLKTLELWKNKLRQVPSALP----- 164

  Fly   127 YAPSLKRLGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANN 191
              .:|:.|.|:.|.:.:. .|..||.|  .:|..|.|.:..|||: ...|::.|.:|:.|.:..|
Mouse   165 --ANLEVLKLNDNAICAL-RGSEFEGL--KNLKVLELKNNLISSL-SPSMLSPLASLQSLMVDGN 223

  Fly   192 QLAQIA---ALPSRTLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYM 253
            .:..:.   :||.  |:.:.:.|..:..:.|....::|||:.|:.|.|                .
Mouse   224 NIESVVGPLSLPH--LKYMSMENNQLHLIPGNVFTSLQNLQFLSFSGN----------------F 270

  Fly   254 LRKLDVSYCNLDSIELSGLPQ-LTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAF 317
            |.|:.::           ||: |..::::.|.|:||......:...|..:.||:|.|..|  |..
Mouse   271 LTKIPIN-----------LPKSLLSLKMERNQLKVVRFRDMKHLENLSHLYLSENFLSSI--DGA 322

  Fly   318 AKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSWCE---IT 379
            .:|..|..|.::.|::..|..   |....|.:|:.|.|.:|::|......:|.:...:.:   ::
Mouse   323 QQLTNLTTLEVSQNQLQMLPP---RLPSRLQKLDCSSNFIQRVTAPEFQDLRDLKHLFLDNNVVS 384

  Fly   380 SIESTALSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVRNNTFREFPELADLHLN 444
            ..|:.||...|.:..|.|..||:..:|..: .:||.:|:|....:..:.....|:..:|..|:|.
Mouse   385 LFEAGALQRCSQLSNLALEQNLLLSIPLRL-PKTLARLDLKGNAIQDMAERELRDLKQLQVLNLR 448

  Fly   445 GNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVDFYDYLTAKPAKIKDRNHLRCAAPAV 509
            .||: |.:.....:|...|..|:|..|||.|.|.   .:...:.|.||...:|..   :|||||.
Mouse   449 NNRI-SALDFKALEGLPRLRHLYLDGNPWNCTCS---LLRAREVLKAKGTDVKGG---QCAAPAE 506

  Fly   510 FYGKLW 515
            ..|:.|
Mouse   507 RQGESW 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	7/21 (33%)
		LRR_RI	<58..236	CDD:238064	49/180 (27%)
		LRR_8	78..141	CDD:290566	17/62 (27%)
		leucine-rich repeat	79..102	CDD:275380	6/22 (27%)
		leucine-rich repeat	103..130	CDD:275380	7/26 (27%)
		leucine-rich repeat	131..155	CDD:275380	8/23 (35%)
		LRR_8	156..214	CDD:290566	15/60 (25%)
		leucine-rich repeat	158..182	CDD:275380	8/23 (35%)
		LRR_8	202..285	CDD:290566	15/83 (18%)
		leucine-rich repeat	204..227	CDD:275380	3/22 (14%)
		leucine-rich repeat	254..274	CDD:275380	3/19 (16%)
		LRR_8	273..333	CDD:290566	17/60 (28%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		LRR_RI	277..>471	CDD:238064	48/196 (24%)
		leucine-rich repeat	299..322	CDD:275380	8/22 (36%)
		LRR_8	321..402	CDD:290566	19/83 (23%)
		leucine-rich repeat	323..346	CDD:275380	5/22 (23%)
		leucine-rich repeat	347..391	CDD:275380	10/46 (22%)
		leucine-rich repeat	392..413	CDD:275380	5/20 (25%)
		LRR_8	393..448	CDD:290566	14/54 (26%)
		leucine-rich repeat	414..437	CDD:275380	4/22 (18%)
		LRRCT	471..517	CDD:214507	16/45 (36%)
Nepn	XP_006512881.1	leucine-rich repeat	101..121	CDD:275380	6/24 (25%)
		leucine-rich repeat	122..145	CDD:275380	6/25 (24%)
		leucine-rich repeat	146..166	CDD:275380	7/26 (27%)
		PRK15370	<148..>367	CDD:185268	64/263 (24%)
		leucine-rich repeat	167..190	CDD:275380	8/25 (32%)
		leucine-rich repeat	191..214	CDD:275380	8/23 (35%)
		leucine-rich repeat	215..236	CDD:275380	4/20 (20%)
		leucine-rich repeat	237..260	CDD:275380	3/22 (14%)
		leucine-rich repeat	261..305	CDD:275380	13/70 (19%)
		PRK15370	<271..>474	CDD:185268	53/220 (24%)
		leucine-rich repeat	282..297	CDD:275380	5/14 (36%)
		leucine-rich repeat	306..327	CDD:275380	8/22 (36%)
		leucine-rich repeat	328..348	CDD:275380	5/22 (23%)
		leucine-rich repeat	349..372	CDD:275380	6/22 (27%)
		leucine-rich repeat	373..396	CDD:275380	3/22 (14%)
		leucine-rich repeat	397..420	CDD:275380	7/23 (30%)
		leucine-rich repeat	421..441	CDD:275380	3/19 (16%)
		leucine-rich repeat	442..465	CDD:275380	7/23 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243556at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010