DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5819 and LINGO3

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001094861.1	Gene:	LINGO3 / 645191	HGNCID:	21206	Length:	592	Species:	Homo sapiens

Alignment Length:	570	Identity:	150/570 - (26%)
Similarity:	214/570 - (37%)	Gaps:	163/570 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VLELALLVLGVISSCRAVNCPWPCRCTWVVDSLYADCSRRSLQTYPNFDGIPVEHLDLSGNKFLE 68
            ||.|.||:|.. :...|..||..|.||  |.:....|:||.|...|  ||||.|      .:.||
Human     7 VLSLPLLLLPA-APPPAGGCPARCECT--VQTRAVACTRRRLTAVP--DGIPAE------TRLLE 60

  Fly    69 FPTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESLSPNEAFKYAPSLKR 133
                           ||.|.|..:....|....:|..|.|:.|:|   ..:.|. ||...|.|:.
Human    61 ---------------LSRNRIRCLNPGDLAALPALEELDLSENAI---AHVEPG-AFANLPRLRV 106

  Fly   134 LGLDGNRLGSFGNGESFELLTSSSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQIAA 198
            |.|.||:|.....| .|..|.:.:|.||..:...|..   |.....|.:|.||.:.:|.|..:
Human   107 LRLRGNQLKLIPPG-VFTRLDNLTLLDLSENKLVILL---DYTFQDLHSLRRLEVGDNDLVFV-- 165

  Fly   199 LPSR-------TLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYMLRK 256
              ||       .|..|.|..|::..|||..|..:::|.||.|   ..|...||.:.     ..|:
Human   166 --SRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRL---RHLAIASLEDQ-----NFRR 220

  Fly   257 LDVSYCNLDSIELSGLPQLTEV---RLQG-NL--LRVVDVNTFA-------NNSMLEVVDLSQNV 308
            |.    .|..:|:...|.|.||   .|:| ||  |.|...|..|       :.:.|..::||.|.
Human   221 LP----GLLHLEIDNWPLLEEVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNP 281

  Fly   309 LRHIGQDAFAKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINM 373
            :..:.:.:|..|.||:||:||...:|
Human   282 ISTVPRGSFRDLVRLRELHLAGALLA--------------------------------------- 307

  Fly   374 SWCEITSIESTALSSLSVIQKLDLSNNLITDM--PTFMRSETLQQLNL------ANCRLTTV--R 428
                  .:|..|...|..|:.|:|||||::.:  .||....||:.|.:      .:|||..:  |
Human   308 ------VVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCRLLWIVQR 366

  Fly   429 NNTFREFPELADLHLNGNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVDFYDYLTAKP 493
            ..|         |:.:| ||.:...|....|:...:   |.|        |.||    :|...:.
Human   367 RKT---------LNFDG-RLPACATPAEVRGDALRN---LPD--------SVLF----EYFVCRK 406

  Fly   494 AKIKDRNHLRCAAPAVFYGKLWEFACADVWILNARTSSTGEKAWSIIMLT 543
            .||::|...|..|.|   |:...|.|          .:.||.|.::..:|
Human   407 PKIRERRLQRVTATA---GEDVRFLC----------RAEGEPAPTVAWVT 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	3/21 (14%)
		LRR_RI	<58..236	CDD:238064	50/184 (27%)
		LRR_8	78..141	CDD:290566	19/62 (31%)
		leucine-rich repeat	79..102	CDD:275380	5/22 (23%)
		leucine-rich repeat	103..130	CDD:275380	8/26 (31%)
		leucine-rich repeat	131..155	CDD:275380	9/23 (39%)
		LRR_8	156..214	CDD:290566	17/64 (27%)
		leucine-rich repeat	158..182	CDD:275380	6/23 (26%)
		LRR_8	202..285	CDD:290566	28/95 (29%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		leucine-rich repeat	254..274	CDD:275380	4/19 (21%)
		LRR_8	273..333	CDD:290566	24/72 (33%)
		leucine-rich repeat	275..298	CDD:275380	11/35 (31%)
		LRR_RI	277..>471	CDD:238064	50/216 (23%)
		leucine-rich repeat	299..322	CDD:275380	6/22 (27%)
		LRR_8	321..402	CDD:290566	16/80 (20%)
		leucine-rich repeat	323..346	CDD:275380	6/22 (27%)
		leucine-rich repeat	347..391	CDD:275380	3/43 (7%)
		leucine-rich repeat	392..413	CDD:275380	9/22 (41%)
		LRR_8	393..448	CDD:290566	18/64 (28%)
		leucine-rich repeat	414..437	CDD:275380	7/30 (23%)
		LRRCT	471..517	CDD:214507	11/45 (24%)
LINGO3	NP_001094861.1	LRRNT	24..58	CDD:214470	16/43 (37%)
		LRR 1	55..76		8/41 (20%)
		LRR_8	57..138	CDD:290566	28/100 (28%)
		LRR_4	59..95	CDD:289563	12/53 (23%)
		leucine-rich repeat	59..79	CDD:275380	7/34 (21%)
		LRR 2	79..100		8/24 (33%)
		leucine-rich repeat	80..103	CDD:275380	8/26 (31%)
		LRR 3	103..124		8/21 (38%)
		leucine-rich repeat	104..127	CDD:275380	9/23 (39%)
		LRR_RI	111..>286	CDD:238064	54/194 (28%)
		LRR_8	127..>172	CDD:290566	13/51 (25%)
		LRR 4	127..148		5/23 (22%)
		leucine-rich repeat	128..151	CDD:275380	6/25 (24%)
		LRR 5	151..172		7/24 (29%)
		leucine-rich repeat	152..199	CDD:275380	15/50 (30%)
		LRR 6	175..196		8/20 (40%)
		LRR_8	198..258	CDD:290566	21/71 (30%)
		leucine-rich repeat	200..223	CDD:275380	9/34 (26%)
		LRR 7	207..228		6/29 (21%)
		leucine-rich repeat	224..247	CDD:275380	8/22 (36%)
		LRR_8	247..303	CDD:290566	17/55 (31%)
		LRR 8	247..268		6/20 (30%)
		leucine-rich repeat	248..271	CDD:275380	5/22 (23%)
		LRR 9	271..292		5/20 (25%)
		leucine-rich repeat	272..293	CDD:275380	5/20 (25%)
		LRR 10	295..316		9/65 (14%)
		leucine-rich repeat	296..319	CDD:275380	9/67 (13%)
		LRR 11	319..340		9/20 (45%)
		leucine-rich repeat	322..343	CDD:275380	8/20 (40%)
		I-set	407..497	CDD:254352	13/50 (26%)
		Ig	422..490	CDD:299845	7/32 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155094
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930