DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5819 and NLRC4

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_001186067.1	Gene:	NLRC4 / 58484	HGNCID:	16412	Length:	1024	Species:	Homo sapiens

Alignment Length:	550	Identity:	107/550 - (19%)
Similarity:	183/550 - (33%)	Gaps:	191/550 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 YPNFDGIP------VEH------------LDLSGNKFLEFPTLYADIDSLIYLDLSSNYISSIGA 94
            |.|...||      .||            ||..|.....:.....|...:...:....||.|...
Human   585 YINSGNIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAV 649

  Fly    95 KTLIG----FTSLRTLLLANNSIDSWESLSPNEAFKYAPSLKRLGLDGNRLGSFGNGESFELLTS 155
            .....    |.:|...|...:.::..:.....:.|..|.||:   |...|........|..|.|.
Human   650 SLFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFSSATSLR---LQIKRCAGVAGSLSLVLSTC 711

  Fly   156 SSLTDLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQIAALPSRTLRVLDLSNCSIKNLSGF 220
            .::..|.:.:..: :|..::.:..:.||                  :||.:.||.|   :.|.|.
Human   712 KNIYSLMVEASPL-TIEDERHITSVTNL------------------KTLSIHDLQN---QRLPGG 754

  Fly   221 FLDAMQNLEALNLSRNTELQFDSL---SEDPI--------------------------LTYMLRK 256
            ..|::.||:.|     |:|..|::   .||.|                          :.|:::.
Human   755 LTDSLGNLKNL-----TKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKS 814

  Fly   257 LDVSYCNLDSIELSGLPQLTEVRLQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAFAKLK 321
            |....|:|:.|      ||....|..|.::::..| ..|...|.::|||:|.|...|.:|..:|
Human   815 LSSEPCDLEEI------QLVSCCLSANAVKILAQN-LHNLVKLSILDLSENYLEKDGNEALHEL- 871

  Fly   322 RLKELNLAFNEIARLDRNFIRNNDVLVELNLSRNVLQKLTKIVSNSVRTINMSW-CEITSIESTA 385
                          :||               .|||::||.::        :.| |::....|:.
Human   872 --------------IDR---------------MNVLEQLTALM--------LPWGCDVQGSLSSL 899

  Fly   386 LSSLSVIQKLDLSNNLITDMPTFMRSETLQQLNLANCRLTTVR---------NNTFREFPELADL 441
            |..|..:.:                   |.:|.|.|.|||...         .|..:.|.:   |
Human   900 LKHLEEVPQ-------------------LVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQ---L 942

  Fly   442 HLNGNRLTSPIPPNYFDGNKFLDQLWLGDNPWICDCHSPLFVD-----FYDYLTAK----PAKIK 497
            :|.|||::|       ||       ||        ....:|.:     |:|:.|.:    ||.::
Human   943 NLAGNRVSS-------DG-------WL--------AFMGVFENLKQLVFFDFSTKEFLPDPALVR 985

  Fly   498 DRNHLRCAAPAVFYGKL--WEFACADVWIL 525
            ..:.:......:...:|  |:|...|:.::
Human   986 KLSQVLSKLTFLQEARLVGWQFDDDDLSVI 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	6/33 (18%)
		LRR_RI	<58..236	CDD:238064	35/193 (18%)
		LRR_8	78..141	CDD:290566	11/66 (17%)
		leucine-rich repeat	79..102	CDD:275380	4/26 (15%)
		leucine-rich repeat	103..130	CDD:275380	4/26 (15%)
		leucine-rich repeat	131..155	CDD:275380	5/23 (22%)
		LRR_8	156..214	CDD:290566	9/57 (16%)
		leucine-rich repeat	158..182	CDD:275380	2/23 (9%)
		LRR_8	202..285	CDD:290566	26/111 (23%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	254..274	CDD:275380	4/19 (21%)
		LRR_8	273..333	CDD:290566	15/59 (25%)
		leucine-rich repeat	275..298	CDD:275380	5/22 (23%)
		LRR_RI	277..>471	CDD:238064	44/203 (22%)
		leucine-rich repeat	299..322	CDD:275380	9/22 (41%)
		LRR_8	321..402	CDD:290566	12/81 (15%)
		leucine-rich repeat	323..346	CDD:275380	2/22 (9%)
		leucine-rich repeat	347..391	CDD:275380	10/44 (23%)
		leucine-rich repeat	392..413	CDD:275380	0/20 (0%)
		LRR_8	393..448	CDD:290566	13/63 (21%)
		leucine-rich repeat	414..437	CDD:275380	9/31 (29%)
		LRRCT	471..517	CDD:214507	8/56 (14%)
NLRC4	NP_001186067.1	CARD	1..87	CDD:279013
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250	95..298
		NACHT	163..316	CDD:283404
		Winged-helix domain (WHD). /evidence=ECO:0000250	356..463
		LRR 1	578..598		4/12 (33%)
		LRR 2	656..679		3/22 (14%)
		leucine-rich repeat	691..713	CDD:275381	5/24 (21%)
		LRR 3	735..758		9/43 (21%)
		LRR_RI	738..978	CDD:238064	73/354 (21%)
		leucine-rich repeat	738..764	CDD:275380	11/46 (24%)
		LRR 4	762..785		8/27 (30%)
		leucine-rich repeat	765..789	CDD:275380	7/28 (25%)
		LRR 5	787..812		1/24 (4%)
		leucine-rich repeat	790..817	CDD:275380	2/26 (8%)
		leucine-rich repeat	822..849	CDD:275380	8/33 (24%)
		LRR 6	824..847		6/29 (21%)
		LRR 7	848..870		8/21 (38%)
		leucine-rich repeat	850..880	CDD:275380	14/59 (24%)
		LRR 8	878..902		7/31 (23%)
		leucine-rich repeat	881..908	CDD:275380	7/34 (21%)
		leucine-rich repeat	909..938	CDD:275380	8/28 (29%)
		LRR 9	911..933		6/21 (29%)
		LRR 10	936..963		12/51 (24%)
		leucine-rich repeat	939..966	CDD:275380	12/51 (24%)
		LRR 11	965..985		5/19 (26%)
		LRR 12	999..1021		4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000