DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5819 and CG7896

DIOPT Version :9

Sequence 1:	NP_001246458.1	Gene:	CG5819 / 37547	FlyBaseID:	FBgn0034717	Length:	915	Species:	Drosophila melanogaster
Sequence 2:	NP_651754.1	Gene:	CG7896 / 43552	FlyBaseID:	FBgn0039728	Length:	1392	Species:	Drosophila melanogaster

Alignment Length:	958	Identity:	220/958 - (22%)
Similarity:	356/958 - (37%)	Gaps:	252/958 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VEHLDLSGNKFLEF-PTLYADIDSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNSIDSWESL 119
            :|.||:|.|..... |..:.::.:|.|||||.|.:.:|....|.|..||:||::.:|:|    .|
  Fly   330 LESLDISRNTITTITPGTFREMGALKYLDLSLNSLRTIEDDALEGLDSLQTLIIKDNNI----LL 390

  Fly   120 SPNEAFKYAPSLKRLGLDGNR--------LGSFGNGE-----------------SFELLTSSSLT 159
            .|..|....|.|..|.||.||        |||...|:                 ||::.  |||.
  Fly   391 VPGSALGRLPQLTSLQLDYNRVAALSAEILGSLQAGDITTLSLSRNVIRELPPGSFQMF--SSLH 453

  Fly   160 DLGLSSCGISSIGGDQMVNQLPNLERLNLANNQLAQIAALP--SRTLRVLDLSNCSIKNLSGFFL 222
            .|.||...::.|..|........|..|.|:.|:|..:...|  ...||.||||..::..|.....
  Fly   454 TLDLSGNSLAVINADTFAGLESTLMALKLSQNRLTGLGGAPWVLPELRSLDLSGNTLTELPSTIF 518

  Fly   223 DAMQNLEALNLSRN-----TELQFDSLSEDPILTYMLRKLDVSYCNLDSIE---LSGLPQLTEVR 279
            :.::|:::||||.|     |...|..|..       |:.:|:|.||:..|.   |:||..|..:.
  Fly   519 EELENVQSLNLSGNHLTPLTGALFKPLDR-------LQVIDLSGCNIRQISGDLLAGLQDLKHIY 576

  Fly   280 LQGNLLRVVDVNTFANNSMLEVVDLSQNVLRHIGQDAFAKLKRLKELNLAFNEIARLDRNFIRNN 344
            |..|.|:.:...:|.|...:..:|||.|.:..|...||..:.:|::|:|..|:::.....:....
  Fly   577 LNDNQLQELQDGSFVNLWNISSIDLSNNRIGSIRSGAFVNVMKLQKLDLHGNQLSAFKGEYFNTG 641

  Fly   345 DVLVELNLSRNVLQKL---TKIVSNSVRTINMSWCEITSIESTALSSLSVIQKLDLSNN------ 400
            ..:.||::|.|.|..|   :..:...:|.|..:..:.:...:..:|:|..::.:|||:|
  Fly   642 TGIEELDISDNQLSYLFPSSFRIHPRLREIRAANNKFSFFPAELISTLQYLEHIDLSHNQLKTIE 706

  Fly   401 ---------------------LITDMPTFMRSETLQQLNLANCRLTTVRNNTFREFPELADLHLN 444
                                 ::::| .|..|..||.|:||:..|..:...||.....|..|:|.
  Fly   707 ELDFARLPRLRVLLVANNQLDMVSEM-AFHNSTQLQILDLAHNNLDRIGERTFEGLVRLEQLNLE 770

  Fly   445 GNRLTSPIPPNYFDGNK--FLDQLWLGDNPWICDCHSPLFVDFYDYLTAKPAKIKDRNHLRCAAP 507
            |||| |.:....|:..|  .|:.:.|..|.             ::|   .|.....|.....::.
  Fly   771 GNRL-SELSDGVFERTKLQMLENINLAHNR-------------FEY---APLNALQRQFFFVSSV 818

  Fly   508 AVFYGKLWEFACADVWILNART-----SSTGEKAWSIIM--------LTLLGLGA---------- 549
            .:.:.|:.|....|..::|.:.     :....||...::        |:|.|.|.
  Fly   819 DLSHNKIKELPGDDSIMVNIKRIDLSFNPLSSKAVHNVLNEPKTVRELSLAGTGIENLELLETPF 883

  Fly   550 ---LVLGYACLQKYLRKRKVRQSDREYEEND---DELRRIRDLNERILREEATPSLQHTQEISLL 608
               |.|.:..|:..  |.:|.|.....|..|   ::|..:.||:      .|.|.||..|.:.:.
  Fly   884 LQFLNLSHNKLKNV--KPEVFQRVTLLETLDLSSNQLESLEDLS------MAWPQLQVLQSLDVS 940

  Fly   609 -PSYE----------DALR--------------------MPKLVR------PVKSMMDLS----- 631
             .|:|          :.||                    :|.||.      |:...:||.
  Fly   941 NNSFEIVSQSNFGKLEMLRSLRLSHLPQCTRIEKNAFKQLPNLVSLEAYDLPLLGYLDLQGILEL 1005

  Fly   632 ----------------GPERARNSRKLRRSQTHADGDGSQSEAEDGL------QLDSRQRFRSVE 674
                            |.|:.:..:..|.......||..:|.:...|      .|..:.|..|:.
  Fly  1006 LPGLEVLDIEVKDSSIGSEQIQPLKHPRLKSLGIRGDRLKSISSGTLAGLKSNDLSVQLRNTSLN 1070

  Fly   675 MLSNRDKERTAQYGPYRRTGYMEYNQSGSR------RF--SIEDSRFPAAHLKTQNLQSAEQIGN 731
            .|.      .|...|..|:.::..|..||:      :|  ::||.|   |.|:.|.|.|
  Fly  1071 ALP------PALLFPVPRSSHLSLNVEGSKITVLVPQFLNALEDRR---ASLQLQGLAS------ 1120

  Fly   732 FQSYENSPYTKRKPKIAE---------IPPFKRVNMMADSVEFLTDPEYDEVGSKHGSPFAKR-- 785
                        .|.:.:         :|.....::...|..:|.:.:..|||....:..|:|
  Fly  1121 ------------NPIVCDCNARALRRWLPSSGMPDVTCASPAYLLNRKLIEVGDDELTCDARRMT 1173

  Fly   786 --KPKPPVLPPPTMKVSAQVYTLQQSPVLELDPAIEDYFSAARKQPSS 831
              ..:|....|..:|.|:|:.|...|...|  |.|  .:|....||.|
  Fly  1174 SSTSRPTASVPHLLKTSSQLVTRSSSTTEE--PLI--IWSLEPTQPPS 1217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5819	NP_001246458.1	leucine-rich repeat	56..78	CDD:275380	6/22 (27%)
		LRR_RI	<58..236	CDD:238064	63/205 (31%)
		LRR_8	78..141	CDD:290566	26/70 (37%)
		leucine-rich repeat	79..102	CDD:275380	10/22 (45%)
		leucine-rich repeat	103..130	CDD:275380	8/26 (31%)
		leucine-rich repeat	131..155	CDD:275380	12/48 (25%)
		LRR_8	156..214	CDD:290566	20/59 (34%)
		leucine-rich repeat	158..182	CDD:275380	6/23 (26%)
		LRR_8	202..285	CDD:290566	28/90 (31%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	254..274	CDD:275380	9/22 (41%)
		LRR_8	273..333	CDD:290566	17/59 (29%)
		leucine-rich repeat	275..298	CDD:275380	6/22 (27%)
		LRR_RI	277..>471	CDD:238064	53/225 (24%)
		leucine-rich repeat	299..322	CDD:275380	7/22 (32%)
		LRR_8	321..402	CDD:290566	18/110 (16%)
		leucine-rich repeat	323..346	CDD:275380	4/22 (18%)
		leucine-rich repeat	347..391	CDD:275380	10/46 (22%)
		leucine-rich repeat	392..413	CDD:275380	7/47 (15%)
		LRR_8	393..448	CDD:290566	20/81 (25%)
		leucine-rich repeat	414..437	CDD:275380	8/22 (36%)
		LRRCT	471..517	CDD:214507	5/45 (11%)
CG7896	NP_651754.1	LRR_8	109..172	CDD:290566
		leucine-rich repeat	109..132	CDD:275380
		LRR_RI	<132..338	CDD:238064	4/7 (57%)
		leucine-rich repeat	133..161	CDD:275380
		LRR_8	160..220	CDD:290566
		leucine-rich repeat	162..185	CDD:275380
		leucine-rich repeat	186..209	CDD:275380
		leucine-rich repeat	210..233	CDD:275380
		LRR_8	232..290	CDD:290566
		leucine-rich repeat	234..257	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		LRR_RI	273..535	CDD:238064	65/210 (31%)
		LRR_8	281..338	CDD:290566	4/7 (57%)
		leucine-rich repeat	282..329	CDD:275380
		LRR_8	328..388	CDD:290566	21/57 (37%)
		leucine-rich repeat	330..353	CDD:275380	6/22 (27%)
		leucine-rich repeat	354..377	CDD:275380	10/22 (45%)
		leucine-rich repeat	378..401	CDD:275380	8/26 (31%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	428..451	CDD:275380	2/24 (8%)
		LRR_8	429..487	CDD:290566	14/59 (24%)
		leucine-rich repeat	452..473	CDD:275380	6/20 (30%)
		leucine-rich repeat	477..497	CDD:275378	6/19 (32%)
		LRR_8	498..558	CDD:290566	20/66 (30%)
		leucine-rich repeat	500..523	CDD:275380	7/22 (32%)
		LRR_RI	502..769	CDD:238064	67/274 (24%)
		leucine-rich repeat	524..547	CDD:275380	8/22 (36%)
		leucine-rich repeat	548..571	CDD:275380	9/22 (41%)
		LRR_8	572..630	CDD:290566	17/57 (30%)
		leucine-rich repeat	572..595	CDD:275380	6/22 (27%)
		leucine-rich repeat	596..619	CDD:275380	7/22 (32%)
		LRR_8	619..678	CDD:290566	12/58 (21%)
		leucine-rich repeat	620..643	CDD:275380	4/22 (18%)
		leucine-rich repeat	644..667	CDD:275380	6/22 (27%)
		LRR_8	666..726	CDD:290566	8/59 (14%)
		leucine-rich repeat	668..691	CDD:275380	4/22 (18%)
		leucine-rich repeat	692..715	CDD:275380	4/22 (18%)
		LRR_8	714..774	CDD:290566	16/60 (27%)
		leucine-rich repeat	716..739	CDD:275380	3/23 (13%)
		leucine-rich repeat	740..761	CDD:275380	8/20 (40%)
		leucine-rich repeat	764..789	CDD:275380	10/25 (40%)
		leucine-rich repeat	790..810	CDD:275380	5/35 (14%)
		leucine-rich repeat	818..850	CDD:275380	4/31 (13%)
		leucine-rich repeat	863..883	CDD:275378	4/19 (21%)
		LRR_RI	<878..1070	CDD:238064	36/199 (18%)
		LRR_8	884..944	CDD:290566	16/67 (24%)
		LRR_4	884..925	CDD:289563	10/42 (24%)
		leucine-rich repeat	884..907	CDD:275380	6/24 (25%)
		leucine-rich repeat	908..933	CDD:275380	8/30 (27%)
		leucine-rich repeat	934..955	CDD:275380	3/20 (15%)
		leucine-rich repeat	958..982	CDD:275380	2/23 (9%)
		leucine-rich repeat	983..1055	CDD:275380	12/71 (17%)
		leucine-rich repeat	1009..1033	CDD:275380	2/23 (9%)
		leucine-rich repeat	1058..1085	CDD:275380	7/32 (22%)
		TPKR_C2	1121..1168	CDD:301599	7/46 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910