DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG5819 and atk

DIOPT Version :9

Sequence 1:NP_001246458.1 Gene:CG5819 / 37547 FlyBaseID:FBgn0034717 Length:915 Species:Drosophila melanogaster
Sequence 2:NP_001262113.1 Gene:atk / 40266 FlyBaseID:FBgn0036995 Length:1535 Species:Drosophila melanogaster


Alignment Length:1040 Identity:233/1040 - (22%)
Similarity:381/1040 - (36%) Gaps:283/1040 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 DGIP-VEHLDLSGNKFLEFPTLYADI---DSLIYLDLSSNYISSIGAKTLIGFTSLRTLLLANNS 112
            |.:| :.:||:|||...|.|  |..:   .:|..|.|:.|::..|....|:...:||.|.:.|||
  Fly   355 DALPRLRYLDMSGNLLSELP--YGALRGHGTLEQLHLNHNHLRLIERDALMAMPALRELRMRNNS 417

  Fly   113 IDS------WE-------SLSPNEAFKY-------APSLKRLGLDGNRL-----GSFGNGESFEL 152
            :.|      |.       .|:.|:..:.       .|||:||.|..|.|     .||.:....|.
  Fly   418 LSSDLPLPFWNLPGLKGLDLAQNQFARVDSQLLAGLPSLRRLDLSENGLIELAPNSFRHNPLLET 482

  Fly   153 L--TSSSLTDLGLSSC----GISSIGGDQMVNQLPN--------LERLNLANNQLAQIAALPSR- 202
            |  :|:.||.:..|:.    .:..:  |...|||.:        :||::|..||:..:.|..|: 
  Fly   483 LNISSNELTKIHSSTLIHLERLFEV--DASYNQLKSVIAGLPRIVERISLKGNQITSLPAAASKD 545

  Fly   203 ----TLRVLDLSNCSIKNLSGFFLDAMQNLEALNLSRNTELQFDSLSEDPILTYMLRKL-DVSYC 262
                .||:||||...|:.|..........|..|:|::|.                ||:| |.|:.
  Fly   546 LQLPNLRMLDLSQNRIEQLPRHGFQGAMELRVLSLAQNE----------------LRQLKDTSFI 594

  Fly   263 NLDSIELSGLPQ-------------LTEVR---LQGNLLRVVDVNTFANNSMLEVVDLSQNVLRH 311
            .:..:||..|.:             |.|:|   ||.|.|..:..|.|:|||.||.:|||:|::|.
  Fly   595 GIQRLELLHLQENQLGEADERALLPLAELRNLNLQSNKLEAITDNFFSNNSRLEQLDLSRNLIRS 659

  Fly   312 IGQDAF-----------------------AKLKRLKELNLAFNEIARLDRNFIRNNDVLVELNLS 353
            |...||                       ..|..|::::|::|:|:|:..:.|.....:||:.||
  Fly   660 ISPTAFDTQRSLEYLDLSGNALLDISVGLGNLNNLRDIDLSYNQISRIQSDVIGGWRNVVEIRLS 724

  Fly   354 RNVLQKLTKIVSNS---VRTINMSWCEITSIESTALSSLSVIQKLDLSNNLITDM---------- 405
            .|::.:|.:....:   ::.:::|..||.::|..||..|..:|:..|::|.:.::          
  Fly   725 NNLIVELQQGTFRNLPKLQYLDLSSNEIRNVEPGALKGLDELQEFVLADNKLVELKDHVFEELPS 789

  Fly   406 ----------------PTFMRSETLQQLNLANCRLTTVRNNTFREFP--ELADLHLNGNRLTSPI 452
                            .:|..:.:|..|||:|.....:.|...|...  |:.||..||.:|.|.:
  Fly   790 LLASHFQYNKLRYISPESFHNANSLVFLNLSNNHFRNMENIGLRSMRNLEVLDLSTNGVKLVSTM 854

  Fly   453 PPNYFDGNKFLDQLWL----GDNPWICDCH-SPLFVDFYDYLTAKPAKIKDRNHLRCAAPAVFYG 512
            |....:        ||    .||..||... ||     ::.:..........|.||......|..
  Fly   855 PLKALN--------WLVELKMDNNQICRIQGSP-----FETMPRLRVLSMRNNQLRSIKERTFRN 906

  Fly   513 KLWEFACAD----------------VWILNARTSSTGEKAW------SIIMLTLLGLGALVLGYA 555
            .....|..|                ||:........|.|..      |..|...|.:||.:.|  
  Fly   907 VRGNIAILDVDGNPIDCNCEMQWLSVWLQETNFPYPGPKCQDGRLLRSARMERSLCVGADIYG-- 969

  Fly   556 CLQKYLRKRKVRQSDREYEENDDELRR--IRDLNERILREEAT------PSLQHTQEISLLPSYE 612
                  .:|..........|:.|..:|  ..|.|:.....|.|      |.:..::  .....|.
  Fly   970 ------NERTDGNQLPLLNEHGDVFQRDLPDDFNDECEAGEGTRLPGDRPLVGESE--YFYDQYV 1026

  Fly   613 DALRMPKLV--------RP-----VKSMMDLSG-----------PERARNS---------RKLRR 644
            ||...|...        ||     :.|.:||:.           |:....|         ..:..
  Fly  1027 DATEAPDTTHSAISTSQRPKPTPTINSNIDLNNTILHTKYFNRKPQPGSGSPFTFFGYPLPSVSL 1091

  Fly   645 SQTHADGD-GSQSEAEDGLQLDSRQRFRSVEMLSNRDKER-----TAQYGPY------------R 691
            .:....|| |.:...:....:.:..|...:.:.|.|.|.|     :|::..|            .
  Fly  1092 GRFFGFGDRGRKQRTDSNDDMPATHRMAHISLPSGRGKTRMYQPNSAEFEKYLKDQQKQEKLNIA 1156

  Fly   692 RTGYMEYNQSGSRRFSIEDSRFPAAHLKTQNLQSAEQIGNFQSYENSPYTKRKPKIAEIPPFKRV 756
            |..|::.:.:.|   |:||:      |..::..:|..:|.|::      |.|:|...|...|:.:
  Fly  1157 RNRYVDTDSTTS---SMEDA------LSNESGSAATTVGVFRT------TFREPSSIERGGFRPI 1206

  Fly   757 NMMADSVEFLT--DPEYD----EVGSKHGSP------FAKRKPKP---PVLPPPTMKVSAQVYTL 806
             :.|....|:.  ||:..    ||.:..|:|      ..:||..|   ...|.|| |.|.:....
  Fly  1207 -VPAHVGGFMPVHDPQQRRGLVEVVNITGNPSEIVQGIGQRKFIPISTQARPKPT-KSSGESSET 1269

  Fly   807 QQSPVLELDPAIEDYFSAARKQPSSSTIASDFQELDEPELKS---LPDDNRSSTISRSDVEQDLE 868
            ....|.|..|.|.......::..:|:|.||...........:   .|.:|.:|:.:..|.:.|.|
  Fly  1270 ATYEVTETTPDITTTTPLMQRIATSTTKASTTTTRSTTTTSTTQVTPAENNASSSTELDSQYDDE 1334

  Fly   869  868
              Fly  1335  1334

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5819NP_001246458.1 leucine-rich repeat 56..78 CDD:275380 8/24 (33%)
LRR_RI <58..236 CDD:238064 62/224 (28%)
LRR_8 78..141 CDD:290566 23/82 (28%)
leucine-rich repeat 79..102 CDD:275380 6/22 (27%)
leucine-rich repeat 103..130 CDD:275380 10/46 (22%)
leucine-rich repeat 131..155 CDD:275380 10/30 (33%)
LRR_8 156..214 CDD:290566 20/74 (27%)
leucine-rich repeat 158..182 CDD:275380 7/27 (26%)
LRR_8 202..285 CDD:290566 26/104 (25%)
leucine-rich repeat 204..227 CDD:275380 8/22 (36%)
leucine-rich repeat 254..274 CDD:275380 8/20 (40%)
LRR_8 273..333 CDD:290566 26/98 (27%)
leucine-rich repeat 275..298 CDD:275380 11/25 (44%)
LRR_RI 277..>471 CDD:238064 62/254 (24%)
leucine-rich repeat 299..322 CDD:275380 11/45 (24%)
LRR_8 321..402 CDD:290566 22/83 (27%)
leucine-rich repeat 323..346 CDD:275380 6/22 (27%)
leucine-rich repeat 347..391 CDD:275380 13/46 (28%)
leucine-rich repeat 392..413 CDD:275380 4/46 (9%)
LRR_8 393..448 CDD:290566 16/82 (20%)
leucine-rich repeat 414..437 CDD:275380 7/24 (29%)
LRRCT 471..517 CDD:214507 9/46 (20%)
atkNP_001262113.1 leucine-rich repeat 69..89 CDD:275380
leucine-rich repeat 90..113 CDD:275380
leucine-rich repeat 115..138 CDD:275380
leucine-rich repeat 139..160 CDD:275380
leucine-rich repeat 161..184 CDD:275380
LRR_8 183..244 CDD:290566
leucine-rich repeat 185..209 CDD:275380
LRR_4 209..247 CDD:289563
leucine-rich repeat 210..233 CDD:275380
leucine-rich repeat 234..259 CDD:275380
LRR_RI 250..492 CDD:238064 40/138 (29%)
LRR_8 259..318 CDD:290566
leucine-rich repeat 260..283 CDD:275380
leucine-rich repeat 284..307 CDD:275380
leucine-rich repeat 308..359 CDD:275380 1/3 (33%)
leucine-rich repeat 334..348 CDD:275378
LRR_8 358..418 CDD:290566 20/61 (33%)
leucine-rich repeat 360..383 CDD:275380 8/24 (33%)
leucine-rich repeat 384..407 CDD:275380 6/22 (27%)
LRR_8 406..466 CDD:290566 17/59 (29%)
leucine-rich repeat 408..431 CDD:275380 8/22 (36%)
leucine-rich repeat 432..455 CDD:275380 2/22 (9%)
LRR_RI 447..705 CDD:238064 73/275 (27%)
LRR_8 454..514 CDD:290566 18/61 (30%)
leucine-rich repeat 456..476 CDD:275380 8/19 (42%)
leucine-rich repeat 480..501 CDD:275380 6/20 (30%)
leucine-rich repeat 505..517 CDD:275378 4/13 (31%)
leucine-rich repeat 525..550 CDD:275380 7/24 (29%)
LRR_8 549..609 CDD:290566 20/75 (27%)
leucine-rich repeat 551..574 CDD:275380 8/22 (36%)
leucine-rich repeat 575..598 CDD:275380 9/38 (24%)
leucine-rich repeat 599..622 CDD:275380 4/22 (18%)
LRR_8 622..681 CDD:290566 21/58 (36%)
leucine-rich repeat 623..646 CDD:275380 9/22 (41%)
LRR_RI 647..896 CDD:238064 58/261 (22%)
leucine-rich repeat 647..670 CDD:275380 10/22 (45%)
leucine-rich repeat 671..693 CDD:275380 1/21 (5%)
leucine-rich repeat 694..717 CDD:275380 6/22 (27%)
LRR_8 716..776 CDD:290566 16/59 (27%)
leucine-rich repeat 718..741 CDD:275380 6/22 (27%)
leucine-rich repeat 742..763 CDD:275380 6/20 (30%)
LRR_8 765..824 CDD:290566 9/58 (16%)
leucine-rich repeat 766..789 CDD:275380 3/22 (14%)
leucine-rich repeat 790..813 CDD:275380 1/22 (5%)
leucine-rich repeat 814..835 CDD:275380 7/20 (35%)
leucine-rich repeat 838..861 CDD:275380 8/30 (27%)
LRR_8 862..921 CDD:290566 13/63 (21%)
leucine-rich repeat 862..885 CDD:275380 7/27 (26%)
leucine-rich repeat 886..906 CDD:275380 4/19 (21%)
TPKR_C2 919..>946 CDD:301599 3/26 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR45617
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
22.010

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